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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Elastic Tissue

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Disease relevance of Elastic Tissue


High impact information on Elastic Tissue


Chemical compound and disease context of Elastic Tissue


Biological context of Elastic Tissue


Anatomical context of Elastic Tissue


Associations of Elastic Tissue with chemical compounds


Gene context of Elastic Tissue

  • Accordingly, we propose that fibrillin-1 provides mostly force-bearing structural support, whereas fibrillin-2 predominantly regulates the early process of elastic fiber assembly [29].
  • The surfaces of disrupted elastic fibers showed IR for MMP-2 and MMP-9 [30].
  • Immunogold labeling of developing nuchal ligament tissue showed that MAGP-2 had regular covalent and periodic (about 56 nm) association with fibrillin-containing microfibrils of elastic fibers in this tissue [31].
  • The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers [32].
  • Our results showed that the pro-regions of LOX and LOXL play a significant role in directing the deposition of both enzymes onto elastic fibers by mediating interactions with tropoelastin [32].

Analytical, diagnostic and therapeutic context of Elastic Tissue


  1. Functional alpha 1-protease inhibitor in the lower respiratory tract of cigarette smokers is not decreased. Stone, P.J., Calore, J.D., McGowan, S.E., Bernardo, J., Snider, G.L., Franzblau, C. Science (1983) [Pubmed]
  2. Acute phase proteins with special reference to C-reactive protein and related proteins (pentaxins) and serum amyloid A protein. Pepys, M.B., Baltz, M.L. Adv. Immunol. (1983) [Pubmed]
  3. Impaired elastogenesis in Hurler disease: dermatan sulfate accumulation linked to deficiency in elastin-binding protein and elastic fiber assembly. Hinek, A., Wilson, S.E. Am. J. Pathol. (2000) [Pubmed]
  4. Cutis laxa: reduced elastin gene expression in skin fibroblast cultures as determined by hybridizations with a homologous cDNA and an exon 1-specific oligonucleotide. Olsen, D.R., Fazio, M.J., Shamban, A.T., Rosenbloom, J., Uitto, J. J. Biol. Chem. (1988) [Pubmed]
  5. Decline in FEV1 among patients with severe hereditary alpha 1-antitrypsin deficiency type PiZ. Seersholm, N., Kok-Jensen, A., Dirksen, A. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  6. Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. Liu, X., Zhao, Y., Gao, J., Pawlyk, B., Starcher, B., Spencer, J.A., Yanagisawa, H., Zuo, J., Li, T. Nat. Genet. (2004) [Pubmed]
  7. A molecular approach to the stratification of cardiovascular risk in families with Marfan's syndrome. Pereira, L., Levran, O., Ramirez, F., Lynch, J.R., Sykes, B., Pyeritz, R.E., Dietz, H.C. N. Engl. J. Med. (1994) [Pubmed]
  8. Distribution of a major connective tissue protein, fibronectin, in normal human tissues. Stenman, S., Vaheri, A. J. Exp. Med. (1978) [Pubmed]
  9. Marked longevity of human lung parenchymal elastic fibers deduced from prevalence of D-aspartate and nuclear weapons-related radiocarbon. Shapiro, S.D., Endicott, S.K., Province, M.A., Pierce, J.A., Campbell, E.J. J. Clin. Invest. (1991) [Pubmed]
  10. Characterization of elastase associated with granulomatous tissue remodeling. Izaki, S., Okamoto, M., Hsu, P.S., Epstein, W.L., Fukuyama, K. J. Cell. Biochem. (1986) [Pubmed]
  11. Morphological changes in oral mucosae and their connective tissue cores regarding oral submucous fibrosis. Yoshimura, K., Dissanayake, U.B., Nanayakkara, D., Kageyama, I., Kobayashi, K. Arch. Histol. Cytol. (2005) [Pubmed]
  12. Lamina propria of the mucosa of benign lesions of the vocal folds. Dikkers, F.G., Nikkels, P.G. Laryngoscope (1999) [Pubmed]
  13. Metalloproteinase-2 and -9 in giant cell arteritis: involvement in vascular remodeling. Rodríguez-Pla, A., Bosch-Gil, J.A., Rosselló-Urgell, J., Huguet-Redecilla, P., Stone, J.H., Vilardell-Tarres, M. Circulation (2005) [Pubmed]
  14. Current applications of orcein in histochemistry. A brief review with some new observations concerning influence of dye batch variation and aging of dye solutions on staining. Henwood, A. Biotechnic & histochemistry : official publication of the Biological Stain Commission. (2003) [Pubmed]
  15. Pathogenetic sequence for aneurysm revealed in mice underexpressing fibrillin-1. Pereira, L., Lee, S.Y., Gayraud, B., Andrikopoulos, K., Shapiro, S.D., Bunton, T., Biery, N.J., Dietz, H.C., Sakai, L.Y., Ramirez, F. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  16. Developmental expression of latent transforming growth factor beta binding protein 2 and its requirement early in mouse development. Shipley, J.M., Mecham, R.P., Maus, E., Bonadio, J., Rosenbloom, J., McCarthy, R.T., Baumann, M.L., Frankfater, C., Segade, F., Shapiro, S.D. Mol. Cell. Biol. (2000) [Pubmed]
  17. A frameshift mutation results in a truncated alpha 1-antitrypsin that is retained within the rough endoplasmic reticulum. Sifers, R.N., Brashears-Macatee, S., Kidd, V.J., Muensch, H., Woo, S.L. J. Biol. Chem. (1988) [Pubmed]
  18. Mice bearing deletions of retinoic acid receptors demonstrate reduced lung elastin and alveolar numbers. McGowan, S., Jackson, S.K., Jenkins-Moore, M., Dai, H.H., Chambon, P., Snyder, J.M. Am. J. Respir. Cell Mol. Biol. (2000) [Pubmed]
  19. Evolution and modulation of age-related medial elastocalcinosis: impact on large artery stiffness and isolated systolic hypertension. Dao, H.H., Essalihi, R., Bouvet, C., Moreau, P. Cardiovasc. Res. (2005) [Pubmed]
  20. Elastin synthesis by ligamentum nuchae fibroblasts: effects of culture conditions and extracellular matrix on elastin production. Mecham, R.P., Lange, G., Madaras, J., Starcher, B. J. Cell Biol. (1981) [Pubmed]
  21. Proteoglycans in primate arteries. I. Ultrastructural localization and distribution in the intima. Wight, T.N., Ross, R. J. Cell Biol. (1975) [Pubmed]
  22. Mutations in the human gene for fibrillin-1 (FBN1) in the Marfan syndrome and related disorders. Dietz, H.C., Pyeritz, R.E. Hum. Mol. Genet. (1995) [Pubmed]
  23. Perinatal lethality and endothelial cell abnormalities in several vessel compartments of fibulin-1-deficient mice. Kostka, G., Giltay, R., Bloch, W., Addicks, K., Timpl, R., Fässler, R., Chu, M.L. Mol. Cell. Biol. (2001) [Pubmed]
  24. Microfibril-associated glycoprotein binds to the carboxyl-terminal domain of tropoelastin and is a substrate for transglutaminase. Brown-Augsburger, P., Broekelmann, T., Mecham, L., Mercer, R., Gibson, M.A., Cleary, E.G., Abrams, W.R., Rosenbloom, J., Mecham, R.P. J. Biol. Chem. (1994) [Pubmed]
  25. Effect of hydralazine on aortic rupture induced by B-aminopropionitrile in turkeys. Simpson, C.F., Taylor, W.J. Circulation (1982) [Pubmed]
  26. Retrovirally mediated overexpression of versican v3 reverses impaired elastogenesis and heightened proliferation exhibited by fibroblasts from Costello syndrome and Hurler disease patients. Hinek, A., Braun, K.R., Liu, K., Wang, Y., Wight, T.N. Am. J. Pathol. (2004) [Pubmed]
  27. Fibrillin-1 interactions with heparin. Implications for microfibril and elastic fiber assembly. Cain, S.A., Baldock, C., Gallagher, J., Morgan, A., Bax, D.V., Weiss, A.S., Shuttleworth, C.A., Kielty, C.M. J. Biol. Chem. (2005) [Pubmed]
  28. Variability of dermal elastin visualized ultrastructurally with iron hematoxylin. Spicer, S.S., Brissie, R.M., Thompson, N.T. Am. J. Pathol. (1975) [Pubmed]
  29. Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils. Zhang, H., Hu, W., Ramirez, F. J. Cell Biol. (1995) [Pubmed]
  30. Immunohistochemistry of matrix metalloproteinases and their inhibitors in thoracic aortic aneurysms and aortic valves of patients with Marfan's syndrome. Segura, A.M., Luna, R.E., Horiba, K., Stetler-Stevenson, W.G., McAllister, H.A., Willerson, J.T., Ferrans, V.J. Circulation (1998) [Pubmed]
  31. MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils. Hanssen, E., Hew, F.H., Moore, E., Gibson, M.A. J. Biol. Chem. (2004) [Pubmed]
  32. The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers. Thomassin, L., Werneck, C.C., Broekelmann, T.J., Gleyzal, C., Hornstra, I.K., Mecham, R.P., Sommer, P. J. Biol. Chem. (2005) [Pubmed]
  33. Emilin, a component of elastic fibers preferentially located at the elastin-microfibrils interface. Bressan, G.M., Daga-Gordini, D., Colombatti, A., Castellani, I., Marigo, V., Volpin, D. J. Cell Biol. (1993) [Pubmed]
  34. Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice. McLaughlin, P.J., Chen, Q., Horiguchi, M., Starcher, B.C., Stanton, J.B., Broekelmann, T.J., Marmorstein, A.D., McKay, B., Mecham, R., Nakamura, T., Marmorstein, L.Y. Mol. Cell. Biol. (2006) [Pubmed]
  35. Bovine latent transforming growth factor beta 1-binding protein 2: molecular cloning, identification of tissue isoforms, and immunolocalization to elastin-associated microfibrils. Gibson, M.A., Hatzinikolas, G., Davis, E.C., Baker, E., Sutherland, G.R., Mecham, R.P. Mol. Cell. Biol. (1995) [Pubmed]
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