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Gene Review

ELN  -  elastin

Bos taurus

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Disease relevance of ELN


High impact information on ELN


Chemical compound and disease context of ELN


Biological context of ELN

  • Binding to tropoelastin was divalent cation-independent and was completely blocked by reduction and alkylation of either protein [8].
  • For both fibrillins, the greatest increase in expression occurred during the last half of fetal development when elastin production is highest [9].
  • In developing bovine aorta, fibrillin mRNA levels again paralleled tropoelastin expression although, compared to ligament, elastin synthesis began at an earlier fetal age in this tissue [9].
  • The alignment of amino acid sequences of porcine tropoelastin tryptic peptides with the sequence for bovine elastin a results in the ordering of these tryptic peptides [10].
  • Nucleotide sequence analysis of cDNA clones for bovine elastin revealed the occurrence of three mRNAs for elastin in fetal calf nuchal ligament, encoding three forms of elastins (a, b, and c, of 747, 733, and 713 amino acid residues, respectively) [10].

Anatomical context of ELN


Associations of ELN with chemical compounds


Physical interactions of ELN


Enzymatic interactions of ELN

  • A significant characteristic of cathepsin S is that it can hydrolyze insoluble elastin at both acidic and neutral pH; this distinguishes it from all of the other lysosomal proteinases [19].

Regulatory relationships of ELN


Other interactions of ELN


Analytical, diagnostic and therapeutic context of ELN


  1. Sequence variation of bovine elastin mRNA due to alternative splicing. Yeh, H., Ornstein-Goldstein, N., Indik, Z., Sheppard, P., Anderson, N., Rosenbloom, J.C., Cicila, G., Yoon, K., Rosenbloom, J. Coll. Relat. Res. (1987) [Pubmed]
  2. Persistence of the fetal pattern of tropoelastin gene expression in severe neonatal bovine pulmonary hypertension. Stenmark, K.R., Durmowicz, A.G., Roby, J.D., Mecham, R.P., Parks, W.C. J. Clin. Invest. (1994) [Pubmed]
  3. Expression and localization of tropoelastin mRNA in the developing bovine pulmonary artery is dependent on vascular cell phenotype. Durmowicz, A.G., Frid, M.G., Wohrley, J.D., Stenmark, K.R. Am. J. Respir. Cell Mol. Biol. (1996) [Pubmed]
  4. Fibroblast adhesion to recombinant tropoelastin expressed as a protein A-fusion protein. Grosso, L.E., Parks, W.C., Wu, L.J., Mecham, R.P. Biochem. J. (1991) [Pubmed]
  5. The elastin receptor: a galactoside-binding protein. Hinek, A., Wrenn, D.S., Mecham, R.P., Barondes, S.H. Science (1988) [Pubmed]
  6. Hypoxia-induced inhibition of tropoelastin synthesis by neonatal calf pulmonary artery smooth muscle cells. Durmowicz, A.G., Badesch, D.B., Parks, W.C., Mecham, R.P., Stenmark, K.R. Am. J. Respir. Cell Mol. Biol. (1991) [Pubmed]
  7. Perfusion dehydration fixes elastin and preserves lung air-space dimensions. Oldmixon, E.H., Suzuki, S., Butler, J.P., Hoppin, F.G. J. Appl. Physiol. (1985) [Pubmed]
  8. Microfibril-associated glycoprotein binds to the carboxyl-terminal domain of tropoelastin and is a substrate for transglutaminase. Brown-Augsburger, P., Broekelmann, T., Mecham, L., Mercer, R., Gibson, M.A., Cleary, E.G., Abrams, W.R., Rosenbloom, J., Mecham, R.P. J. Biol. Chem. (1994) [Pubmed]
  9. Fibrillin-1 and fibrillin-2 show temporal and tissue-specific regulation of expression in developing elastic tissues. Mariencheck, M.C., Davis, E.C., Zhang, H., Ramirez, F., Rosenbloom, J., Gibson, M.A., Parks, W.C., Mecham, R.P. Connect. Tissue Res. (1995) [Pubmed]
  10. Primary structures of bovine elastin a, b, and c deduced from the sequences of cDNA clones. Raju, K., Anwar, R.A. J. Biol. Chem. (1987) [Pubmed]
  11. Ultrastructural immunolocalization of lysyl oxidase in vascular connective tissue. Kagan, H.M., Vaccaro, C.A., Bronson, R.E., Tang, S.S., Brody, J.S. J. Cell Biol. (1986) [Pubmed]
  12. Accelerated calcification represses the expression of elastic fiber components and lysyl oxidase in cultured bovine aortic smooth muscle cells. Sugitani, H., Wachi, H., Mecham, R.P., Seyama, Y. J. Atheroscler. Thromb. (2002) [Pubmed]
  13. Deposition of tropoelastin into the extracellular matrix requires a competent elastic fiber scaffold but not live cells. Kozel, B.A., Ciliberto, C.H., Mecham, R.P. Matrix Biol. (2004) [Pubmed]
  14. Hydrogen peroxide-mediated, lysyl oxidase-dependent chemotaxis of vascular smooth muscle cells. Li, W., Liu, G., Chou, I.N., Kagan, H.M. J. Cell. Biochem. (2000) [Pubmed]
  15. Structure of the 3' portion of the bovine elastin gene. Cicila, G., May, M., Ornstein-Goldstein, N., Indik, Z., Morrow, S., Yeh, H.S., Rosenbloom, J., Boyd, C., Rosenbloom, J., Yoon, K. Biochemistry (1985) [Pubmed]
  16. Influence of sequence and charge on the specificity of lysyl oxidase toward protein and synthetic peptide substrates. Kagan, H.M., Williams, M.A., Williamson, P.R., Anderson, J.M. J. Biol. Chem. (1984) [Pubmed]
  17. The protein components of the 12-nanometer microfibrils of elastic and nonelastic tissues. Gibson, M.A., Kumaratilake, J.S., Cleary, E.G. J. Biol. Chem. (1989) [Pubmed]
  18. Beta-substituted ethylamine derivatives as suicide inhibitors of lysyl oxidase. Tang, S.S., Simpson, D.E., Kagan, H.M. J. Biol. Chem. (1984) [Pubmed]
  19. The specificity and elastinolytic activities of bovine cathepsins S and H. Xin, X.Q., Gunesekera, B., Mason, R.W. Arch. Biochem. Biophys. (1992) [Pubmed]
  20. Insulin-like growth factor I stimulates elastin synthesis by bovine pulmonary arterial smooth muscle cells. Badesch, D.B., Lee, P.D., Parks, W.C., Stenmark, K.R. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  21. Complementary DNA cloning establishes microfibril-associated glycoprotein (MAGP) to be a discrete component of the elastin-associated microfibrils. Gibson, M.A., Sandberg, L.B., Grosso, L.E., Cleary, E.G. J. Biol. Chem. (1991) [Pubmed]
  22. Persistence, re-expression, and induction of pulmonary arterial fibronectin, tropoelastin, and type I procollagen mRNA expression in neonatal hypoxic pulmonary hypertension. Durmowicz, A.G., Parks, W.C., Hyde, D.M., Mecham, R.P., Stenmark, K.R. Am. J. Pathol. (1994) [Pubmed]
  23. Structure of the bovine elastin gene and S1 nuclease analysis of alternative splicing of elastin mRNA in the bovine nuchal ligament. Yeh, H., Anderson, N., Ornstein-Goldstein, N., Bashir, M.M., Rosenbloom, J.C., Abrams, W., Indik, Z., Yoon, K., Parks, W., Mecham, R. Biochemistry (1989) [Pubmed]
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