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Gene Review

MC4R  -  melanocortin 4 receptor

Bos taurus

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High impact information on MC4R

  • We showed that Agrp inhibited, in a dose-dependent manner, the 10(-9) M NDP-alphaMSH-induced cortisol production through its antagonistic properties towards MSH at the level of MC4-R [1].

Analytical, diagnostic and therapeutic context of MC4R


  1. Sustained inhibitory effect of Agouti Related Protein on the ACTH-induced cortisol production by bovine cultured adrenal cells. Doghman, M., Delagrange, P., Berthelon, M.C., Durand, P., Naville, D., Bégeot, M. Regul. Pept. (2005) [Pubmed]
  2. Bovine melanocortin receptor 4: cDNA sequence, polymorphisms and mapping. Haegeman, A., Coopman, F., Jacobs, K., Mattheeuws, M., Van Zeveren, A., Peelman, L. Anim. Genet. (2001) [Pubmed]
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