Gene Review:
Mc4r - melanocortin 4 receptor
Mus musculus
Synonyms:
Fatboy, Glu3, MC4-R, Melanocortin receptor 4
- Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Marsh, D.J., Hollopeter, G., Huszar, D., Laufer, R., Yagaloff, K.A., Fisher, S.L., Burn, P., Palmiter, R.D. Nat. Genet. (1999)
- A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors. Ste Marie, L., Miura, G.I., Marsh, D.J., Yagaloff, K., Palmiter, R.D. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. Butler, A.A., Marks, D.L., Fan, W., Kuhn, C.M., Bartolome, M., Cone, R.D. Nat. Neurosci. (2001)
- Leptin and inflammation-associated cachexia in chronic kidney disease. Mak, R.H., Cheung, W., Cone, R.D., Marks, D.L. Kidney Int. (2006)
- Impaired coordination of nutrient intake and substrate oxidation in melanocortin-4 receptor knockout mice. Albarado, D.C., McClaine, J., Stephens, J.M., Mynatt, R.L., Ye, J., Bannon, A.W., Richards, W.G., Butler, A.A. Endocrinology (2004)
- Mahogany (mg) stimulates feeding and increases basal metabolic rate independent of its suppression of agouti. Dinulescu, D.M., Fan, W., Boston, B.A., McCall, K., Lamoreux, M.L., Moore, K.J., Montagno, J., Cone, R.D. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Morphine down-regulates melanocortin-4 receptor expression in brain regions that mediate opiate addiction. Alvaro, J.D., Tatro, J.B., Quillan, J.M., Fogliano, M., Eisenhard, M., Lerner, M.R., Nestler, E.J., Duman, R.S. Mol. Pharmacol. (1996)
- Divergence of melanocortin pathways in the control of food intake and energy expenditure. Balthasar, N., Dalgaard, L.T., Lee, C.E., Yu, J., Funahashi, H., Williams, T., Ferreira, M., Tang, V., McGovern, R.A., Kenny, C.D., Christiansen, L.M., Edelstein, E., Choi, B., Boss, O., Aschkenasi, C., Zhang, C.Y., Mountjoy, K., Kishi, T., Elmquist, J.K., Lowell, B.B. Cell (2005)
- Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Chen, A.S., Marsh, D.J., Trumbauer, M.E., Frazier, E.G., Guan, X.M., Yu, H., Rosenblum, C.I., Vongs, A., Feng, Y., Cao, L., Metzger, J.M., Strack, A.M., Camacho, R.E., Mellin, T.N., Nunes, C.N., Min, W., Fisher, J., Gopal-Truter, S., MacIntyre, D.E., Chen, H.Y., Van der Ploeg, L.H. Nat. Genet. (2000)
- Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Huszar, D., Lynch, C.A., Fairchild-Huntress, V., Dunmore, J.H., Fang, Q., Berkemeier, L.R., Gu, W., Kesterson, R.A., Boston, B.A., Cone, R.D., Smith, F.J., Campfield, L.A., Burn, P., Lee, F. Cell (1997)
- The mahoganoid mutation (Mgrn1md) improves insulin sensitivity in mice with mutations in the melanocortin signaling pathway independently of effects on adiposity. Phan, L.K., Chung, W.K., Leibel, R.L. Am. J. Physiol. Endocrinol. Metab. (2006)
- Role of the central melanocortin system in cachexia. Marks, D.L., Ling, N., Cone, R.D. Cancer Res. (2001)
- Evidence that orexigenic effects of melanocortin 4 receptor antagonist HS014 are mediated by neuropeptide Y. Kask, A., Rägo, L., Korrovits, P., Wikberg, J.E., Schiöth, H.B. Biochem. Biophys. Res. Commun. (1998)
- Double leptin and melanocortin-4 receptor gene mutations have an additive effect on fat mass and are associated with reduced effects of leptin on weight loss and food intake. Trevaskis, J.L., Butler, A.A. Endocrinology (2005)
- Effect of Agouti-related protein in regulation of the hypothalamic-pituitary-thyroid axis in the melanocortin 4 receptor knockout mouse. Fekete, C., Marks, D.L., Sarkar, S., Emerson, C.H., Rand, W.M., Cone, R.D., Lechan, R.M. Endocrinology (2004)
- Characterization of a novel binding partner of the melanocortin-4 receptor: attractin-like protein. Haqq, A.M., René, P., Kishi, T., Khong, K., Lee, C.E., Liu, H., Friedman, J.M., Elmquist, J.K., Cone, R.D. Biochem. J. (2003)
- Age-dependent hypothalamic expression of neuropeptides in wild-type and melanocortin-4 receptor-deficient mice. Arens, J., Moar, K.M., Eiden, S., Weide, K., Schmidt, I., Mercer, J.G., Simon, E., Korf, H.W. Physiol. Genomics (2003)
- Targeted deletion of melanocortin receptor subtypes 3 and 4, but not CART, alters nutrient partitioning and compromises behavioral and metabolic responses to leptin. Zhang, Y., Kilroy, G.E., Henagan, T.M., Prpic-Uhing, V., Richards, W.G., Bannon, A.W., Mynatt, R.L., Gettys, T.W. FASEB J. (2005)
- Regulation of adipose tissue leptin secretion by alpha-melanocyte-stimulating hormone and agouti-related protein: further evidence of an interaction between leptin and the melanocortin signalling system. Hoggard, N., Hunter, L., Duncan, J.S., Rayner, D.V. J. Mol. Endocrinol. (2004)
- Effects of melanocortin receptor activation and blockade on ethanol intake: a possible role for the melanocortin-4 receptor. Navarro, M., Cubero, I., Chen, A.S., Chen, H.Y., Knapp, D.J., Breese, G.R., Marsh, D.J., Thiele, T.E. Alcohol. Clin. Exp. Res. (2005)
- Neuronal histamine regulates food intake, adiposity, and uncoupling protein expression in agouti yellow (A(y)/a) obese mice. Masaki, T., Chiba, S., Yoshimichi, G., Yasuda, T., Noguchi, H., Kakuma, T., Sakata, T., Yoshimatsu, H. Endocrinology (2003)
- Melanocortin receptor binding determinants in the agouti protein. Kiefer, L.L., Veal, J.M., Mountjoy, K.G., Wilkison, W.O. Biochemistry (1998)
- Expression of functional melanocortin-4 receptor in the hypothalamic GT1-1 cell line. Khong, K., Kurtz, S.E., Sykes, R.L., Cone, R.D. Neuroendocrinology (2001)
- 11 beta-hydroxysteroid dehydrogenase type 1 induction in the arcuate nucleus by high-fat feeding: A novel constraint to hyperphagia? Densmore, V.S., Morton, N.M., Mullins, J.J., Seckl, J.R. Endocrinology (2006)
- Neuropeptide Y Y1 receptor mRNA in rodent brain: distribution and colocalization with melanocortin-4 receptor. Kishi, T., Aschkenasi, C.J., Choi, B.J., Lopez, M.E., Lee, C.E., Liu, H., Hollenberg, A.N., Friedman, J.M., Elmquist, J.K. J. Comp. Neurol. (2005)
- A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences. Benoit, S.C., Schwartz, M.W., Lachey, J.L., Hagan, M.M., Rushing, P.A., Blake, K.A., Yagaloff, K.A., Kurylko, G., Franco, L., Danhoo, W., Seeley, R.J. J. Neurosci. (2000)
- MC-3 receptor and the inflammatory mechanisms activated in acute myocardial infarct. Getting, S.J., Di Filippo, C., Christian, H.C., Lam, C.W., Rossi, F., D'Amico, M., Perretti, M. J. Leukoc. Biol. (2004)
- Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. Gantz, I., Miwa, H., Konda, Y., Shimoto, Y., Tashiro, T., Watson, S.J., DelValle, J., Yamada, T. J. Biol. Chem. (1993)
- Melanocortin-4 receptor mediates chronic cardiovascular and metabolic actions of leptin. Tallam, L.S., da Silva, A.A., Hall, J.E. Hypertension (2006)
- Structure-activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH(2) at the mouse melanocortin receptors: part 2 modifications at the Phe position. Holder, J.R., Bauzo, R.M., Xiang, Z., Haskell-Luevano, C. J. Med. Chem. (2002)