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Gene Review

MC4R  -  melanocortin 4 receptor

Gallus gallus

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High impact information on MC4R

  • The alpha-MSH-elicited CORT release was not attenuated by the injection of agouti-related protein, an endogenous melanocortin-4 (MC4) receptor antagonist, suggesting that alpha-MSH stimulated CRF neurons through MC4 receptor-independent pathways [1].
  • This article reviews our work on MC1R variants in horse, pig, and chicken, as well as a study on MC4R polymorphism in the pig [2].
  • To examine whether or not the peripheral melanocortin 4 receptor signaling could be regulated by AGRP, we cloned and localized the expression of the AGRP gene in the chicken [3].


  1. The anorexic effect of alpha-melanocyte-stimulating hormone is mediated by corticotrophin-releasing factor in chicks. Tachibana, T., Oikawa, D., Takahashi, H., Boswell, T., Furuse, M. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (2007) [Pubmed]
  2. Melanocortin receptor variants with phenotypic effects in horse, pig, and chicken. Andersson, L. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
  3. Widespread expression of Agouti-related protein (AGRP) in the chicken: a possible involvement of AGRP in regulating peripheral melanocortin systems in the chicken. Takeuchi, S., Teshigawara, K., Takahashi, S. Biochim. Biophys. Acta (2000) [Pubmed]
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