Gene Review:
Mc4r - melanocortin 4 receptor
Rattus norvegicus
Synonyms:
MC4-R, Melanocortin receptor 4
- Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat. Kishi, T., Aschkenasi, C.J., Lee, C.E., Mountjoy, K.G., Saper, C.B., Elmquist, J.K. J. Comp. Neurol. (2003)
- Melanocortin-4 receptor messenger RNA expression is up-regulated in the non-damaged striatum following unilateral hypoxic-ischaemic brain injury. Mountjoy, K.G., Guan, J., Elia, C.J., Sirimanne, E.S., Williams, C.E. Neuroscience (1999)
- Melanocortin 4 receptor is expressed in the dorsal root ganglions and down-regulated in neuropathic rats. Starowicz, K., Bilecki, W., Sieja, A., Przewlocka, B., Przewlocki, R. Neurosci. Lett. (2004)
- Activation of central melanocortin-4 receptor suppresses lipopolysaccharide-induced fever in rats. Sinha, P.S., Schiöth, H.B., Tatro, J.B. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2003)
- Melanocortin antagonists define two distinct pathways of cardiovascular control by alpha- and gamma-melanocyte-stimulating hormones. Li, S.J., Varga, K., Archer, P., Hruby, V.J., Sharma, S.D., Kesterson, R.A., Cone, R.D., Kunos, G. J. Neurosci. (1996)
- Role of central melanocortins in endotoxin-induced anorexia. Huang, Q.H., Hruby, V.J., Tatro, J.B. Am. J. Physiol. (1999)
- Food deprivation decreases responsiveness of ventromedial hypothalamic neurons to melanocortins. Li, Y.Z., Davidowa, H. J. Neurosci. Res. (2004)
- Molecular and behavioral interactions between central melanocortins and cocaine. Alvaro, J.D., Taylor, J.R., Duman, R.S. J. Pharmacol. Exp. Ther. (2003)
- Anxiolytic-like effect of a selective and non-peptidergic melanocortin 4 receptor antagonist, MCL0129, in a social interaction test. Shimazaki, T., Chaki, S. Pharmacol. Biochem. Behav. (2005)
- Brainstem application of melanocortin receptor ligands produces long-lasting effects on feeding and body weight. Grill, H.J., Ginsberg, A.B., Seeley, R.J., Kaplan, J.M. J. Neurosci. (1998)
- Identification of domains directing specificity of coupling to G-proteins for the melanocortin MC3 and MC4 receptors. Kim, C.S., Lee, S.H., Kim, R.Y., Kim, B.J., Li, S.Z., Lee, I.H., Lee, E.J., Lim, S.K., Bae, Y.S., Lee, W., Baik, J.H. J. Biol. Chem. (2002)
- Chronic central melanocortin-4 receptor antagonism and central neuropeptide-Y infusion in rats produce increased adiposity by divergent pathways. Baran, K., Preston, E., Wilks, D., Cooney, G.J., Kraegen, E.W., Sainsbury, A. Diabetes (2002)
- Gastric mucosal damage following repeat administration of melanocortin subtype-4 receptor ligands to Fischer 344 rats. Williams, T.M., Donnelly, K.B. Toxicologic pathology (2006)
- Investigation of the melanocyte stimulating hormones on food intake. Lack Of evidence to support a role for the melanocortin-3-receptor. Abbott, C.R., Rossi, M., Kim, M., AlAhmed, S.H., Taylor, G.M., Ghatei, M.A., Smith, D.M., Bloom, S.R. Brain Res. (2000)
- Regulation of CRF, POMC and MC4R gene expression after electrical foot shock stress in the rat amygdala and hypothalamus. Yamano, Y., Yoshioka, M., Toda, Y., Oshida, Y., Chaki, S., Hamamoto, K., Morishima, I. J. Vet. Med. Sci. (2004)
- Brainstem melanocortin 3/4 receptor stimulation increases uncoupling protein gene expression in brown fat. Williams, D.L., Bowers, R.R., Bartness, T.J., Kaplan, J.M., Grill, H.J. Endocrinology (2003)
- The effect of morphine on MC4 and CRF receptor mRNAs in the rat amygdala and attenuation of tolerance after their blockade. Starowicz, K., Sieja, A., Bilecki, W., Obara, I., Przewlocka, B. Brain Res. (2003)
- Different developmental patterns of melanocortin MC3 and MC4 receptor mRNA: predominance of Mc4 in fetal rat nervous system. Kistler-Heer, V., Lauber, M.E., Lichtensteiger, W. J. Neuroendocrinol. (1998)
- Interaction between alpha-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses. Lu, X.Y., Barsh, G.S., Akil, H., Watson, S.J. J. Neurosci. (2003)
- Evidence for an interaction between CB1 cannabinoid and melanocortin MCR-4 receptors in regulating food intake. Verty, A.N., McFarlane, J.R., McGregor, I.S., Mallet, P.E. Endocrinology (2004)
- Evaluation of the role of melanocortin 3 and 4 receptors in leptin-stimulated and spontaneous growth hormone secretion in rats. Watanobe, H., Yoneda, M. Neuroendocrinology (2003)
- Physiologic estradiol levels enhance hypothalamic expression of the long form of the leptin receptor in intact rats. Rocha, M., Bing, C., Williams, G., Puerta, M. J. Nutr. Biochem. (2004)
- Corticotropin-releasing factor (CRF) induced anorexia is not influenced by a melanocortin 4 receptor blockage. Vergoni, A.V., Bertolini, A., Wikberg, J.E., Schiöth, H.B. Peptides (1999)
- Altered energy balance causes selective changes in melanocortin-4(MC4-R), but not melanocortin-3 (MC3-R), receptors in specific hypothalamic regions: further evidence that activation of MC4-R is a physiological inhibitor of feeding. Harrold, J.A., Widdowson, P.S., Williams, G. Diabetes (1999)
- Alpha-melanocyte-stimulating hormone through melanocortin-4 receptor inhibits nitric oxide synthase and cyclooxygenase expression in the hypothalamus of male rats. Caruso, C., Mohn, C., Karara, A.L., Rettori, V., Watanobe, H., Schiöth, H.B., Seilicovich, A., Lasaga, M. Neuroendocrinology (2004)
- Orexigenic effect of the melanocortin MC4 receptor antagonist HS014 is inhibited only partially by neuropeptide Y Y1 receptor selective antagonists. Kask, A., Schiöth, H.B., Harro, J., Wikberg, J.E., Rägo, L. Can. J. Physiol. Pharmacol. (2000)
- Pivotal roles of alpha-melanocyte-stimulating hormone and the melanocortin 4 receptor in leptin stimulation of prolactin secretion in rats. Watanobe, H., Schiöth, H.B., Izumi, J. J. Neurochem. (2003)
- Cocaine- and amphetamine-regulated transcript, glucagon-like peptide-1 and corticotrophin releasing factor inhibit feeding via agouti-related protein independent pathways in the rat. Edwards, C.M., Abbott, C.R., Sunter, D., Kim, M., Dakin, C.L., Murphy, K.G., Abusnana, S., Taheri, S., Rossi, M., Bloom, S.R. Brain Res. (2000)
- Anatomy of an endogenous antagonist: relationship between Agouti-related protein and proopiomelanocortin in brain. Bagnol, D., Lu, X.Y., Kaelin, C.B., Day, H.E., Ollmann, M., Gantz, I., Akil, H., Barsh, G.S., Watson, S.J. J. Neurosci. (1999)
- Melanocortin-4 receptor messenger ribonucleic acid expression in rat cardiorespiratory, musculoskeletal, and integumentary systems. Mountjoy, K.G., Jenny Wu, C.S., Dumont, L.M., Wild, J.M. Endocrinology (2003)
- Melanocortins and feeding behavior. Vergoni, A.V., Schiöth, H.B., Bertolini, A. Biomed. Pharmacother. (2000)
- The role of the dorsal vagal complex and the vagus nerve in feeding effects of melanocortin-3/4 receptor stimulation. Williams, D.L., Kaplan, J.M., Grill, H.J. Endocrinology (2000)