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TRPC1  -  transient receptor potential cation...

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High impact information on TRPC1

  • These results suggest that BAE-1 cells are a suitable model to study function and regulation of endogenous TRPC1/TRPC4 heteromers [1].
  • Moreover, the data show that TRPC subunits are not tyrosine-phosphorylated after bFGF stimulation and they do not co-immunoprecipitate with the type 1 FGF receptor [1].
  • Interaction between TRPC channel subunits in endothelial cells [1].
  • Transient Receptor Potential Canonical (TRPC) proteins have been identified in mammals as a family of plasma membrane calcium-permeable channels activated by different kinds of stimuli in several cell types [1].

Analytical, diagnostic and therapeutic context of TRPC1

  • By means of a RT-PCR approach, we have found that, in addition to TRPC1, only TRPC4 is expressed, both at the mRNA and protein level, as confirmed by immunoblotting and immunocytochemical analysis [1].


  1. Interaction between TRPC channel subunits in endothelial cells. Antoniotti, S., Pla, A.F., Barral, S., Scalabrino, O., Munaron, L., Lovisolo, D. J. Recept. Signal Transduct. Res. (2006) [Pubmed]
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