The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Trpc1  -  transient receptor potential cation...

Mus musculus

Synonyms: Mtrp1, Short transient receptor potential channel 1, TRP-1, Transient receptor protein 1, Trp-related protein 1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Trpc1


High impact information on Trpc1

  • We reported the existence of six trp-related genes in the mouse genome [3].
  • Currents similar to these are produced by the mammalian trp-related channels, a gene family that includes Ca2+ store-operated channels and inositol 1,4,5-trisphosphate-activated channels [4].
  • Immunoconfocal images showed that while Trp6 was present in the postacrosomal region and could be involved in sperm AR, expression of Trp1 and Trp3 was confined to the flagellum, suggesting that they may serve sperm to regulate important Ca(2+)-dependent events in addition to the AR [5].
  • Likewise, one of these proteins (Trp1) co-immunolocalized with caveolin-1, a major component of caveolae, a subset of lipid rafts potentially important for signaling events and Ca(2+) flux [5].
  • Genetic mapping of mouse transient receptor potential (Trrp) genes responsible for capacitative calcium entry channels to chromosomes 3, 7, 9, and X [6].

Biological context of Trpc1


Anatomical context of Trpc1


Associations of Trpc1 with chemical compounds

  • We identified five different trp-related amplifications of reverse-transcription-polymerase chain reaction (RT-PCR) from rat brain; these corresponded to mouse trp homologues, mtrp1,3,4,5,6 and were distributed in various tissues with multiple expression levels [12].


  1. Transient receptor potential vanilloid subfamily 1 is essential for the generation of noxious bladder input and bladder overactivity in cystitis. Charrua, A., Cruz, C.D., Cruz, F., Avelino, A. J. Urol. (2007) [Pubmed]
  2. Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury. Alvarez, D.F., King, J.A., Weber, D., Addison, E., Liedtke, W., Townsley, M.I. Circ. Res. (2006) [Pubmed]
  3. trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry. Zhu, X., Jiang, M., Peyton, M., Boulay, G., Hurst, R., Stefani, E., Birnbaumer, L. Cell (1996) [Pubmed]
  4. Characterization of a Ca2+ release-activated nonselective cation current regulating membrane potential and [Ca2+]i oscillations in transgenically derived beta-cells. Roe, M.W., Worley, J.F., Qian, F., Tamarina, N., Mittal, A.A., Dralyuk, F., Blair, N.T., Mertz, R.J., Philipson, L.H., Dukes, I.D. J. Biol. Chem. (1998) [Pubmed]
  5. Identification of mouse trp homologs and lipid rafts from spermatogenic cells and sperm. Treviño, C.L., Serrano, C.J., Beltrán, C., Felix, R., Darszon, A. FEBS Lett. (2001) [Pubmed]
  6. Genetic mapping of mouse transient receptor potential (Trrp) genes responsible for capacitative calcium entry channels to chromosomes 3, 7, 9, and X. Yamazaki, K., Okada, T., Mori, Y., Tanaka, I. Genomics (1998) [Pubmed]
  7. Cloning and pharmacological characterization of mouse TRPV1. Correll, C.C., Phelps, P.T., Anthes, J.C., Umland, S., Greenfeder, S. Neurosci. Lett. (2004) [Pubmed]
  8. Transient receptor potential melastatin 7 ion channels regulate magnesium homeostasis in vascular smooth muscle cells: role of angiotensin II. He, Y., Yao, G., Savoia, C., Touyz, R.M. Circ. Res. (2005) [Pubmed]
  9. Involvement of TRPV1-dependent and -independent components in the regulation of vagally induced contractions in the mouse esophagus. Boudaka, A., Wörl, J., Shiina, T., Neuhuber, W.L., Kobayashi, H., Shimizu, Y., Takewaki, T. Eur. J. Pharmacol. (2007) [Pubmed]
  10. Attenuation of experimental arthritis in TRPV1R knockout mice. Barton, N.J., McQueen, D.S., Thomson, D., Gauldie, S.D., Wilson, A.W., Salter, D.M., Chessell, I.P. Exp. Mol. Pathol. (2006) [Pubmed]
  11. Transient receptor potential vanilloid 1 is required for intrinsic osmoreception in organum vasculosum lamina terminalis neurons and for normal thirst responses to systemic hyperosmolality. Ciura, S., Bourque, C.W. J. Neurosci. (2006) [Pubmed]
  12. Molecular cloning and characterization of rat trp homologues from brain. Mizuno, N., Kitayama, S., Saishin, Y., Shimada, S., Morita, K., Mitsuhata, C., Kurihara, H., Dohi, T. Brain Res. Mol. Brain Res. (1999) [Pubmed]
WikiGenes - Universities