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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

COX6A1  -  cytochrome c oxidase subunit VIa...

Bos taurus

 
 
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High impact information on COX6A1

  • Gamma-globulins can be crosslinked at low concentrations by simultaneous treatment with sodium sulphate and glutaraldehyde (SSG-method) [1].
  • Additional bands of about 50/55 kDa were also detected in lysates of SSG/94 and VERO cells by immunoprecipitation [2].
  • The rabbit anti-GRN antibody bound to structurally related antitumor (1-->6)-branched (1-->3)-beta-D-glucans such as lentinan, schizophyllan and SSG, whereas it did not react with linear (1-->3)-beta-D-glucan, curdlan or GRN-derivatives obtained by periodate-oxidation and Smith degradation [3].
  • The bovine gene for the nuclear-encoded heart/muscle isoform of cytochrome c oxidase subunit VIa (COX6A1) was isolated from a library of bovine genomic DNA in lambda EMBL3 and sequenced [4].
  • Primer extension and ribonuclease protection assays were used to map the 5' ends of COX6A1 transcripts in heart; both methods identified several clusters of transcription initiation sites, indicating that COX6A1 mRNA is heterogeneous at the 5' end [4].

References

  1. Measurement of antibody and antigen concentrations with a sodium sulphate glutaraldehyde technique. Keck, K. J. Immunol. Methods (1978) [Pubmed]
  2. Discrete cleavage patterns of pseudorabies virus immediate early protein (IE180) seen in some cell lines upon extraction after cycloheximide reversal. Garmendia, A.E., Lu, Z., Tulman, E.R. J. Virol. Methods (1997) [Pubmed]
  3. Preparation and antigen specificity of an anti-(1-->3)-beta-D-glucan antibody. Adachi, Y., Ohno, N., Yadomae, T. Biol. Pharm. Bull. (1994) [Pubmed]
  4. Structural organization of the bovine gene for the heart/muscle isoform of cytochrome c oxidase subunit VIa. Smith, E.O., Lomax, M.I. Biochim. Biophys. Acta (1993) [Pubmed]
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