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Chemical Compound Review

SIZOFIRAN     (2S,3R,4S,5S,6R)-2- [(2S,3R,4S,5S,6R)-3,5...

Synonyms: Somfilan, Sizofiranum, Schizophyllan, Schizophyllane, SureCN1517238, ...
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Disease relevance of Schizophyllan

  • Female C3H mice aged 8-10 weeks with transplanted KHT sarcoma or SCCVII tumor were used to investigate the antitumor effect of SPG (Sonifilan, Schizophyllan) alone and in combination with local irradiation of pions with 4 fractions of 400 cGy (total 1600 cGy) [1].
  • Subsequently, we made a complex from PEG-appended schizophyllan and an AS ODN sequence, and carried out an in vitro antisense assay, administrating the AS ODN complex to depress A375 c-myb mRNA of A375 melanoma cell lines [2].
  • On the other hand, schizophyllan did not influence interferon production in mice whether or not infected with Sendai virus [3].
  • Treatment of squamous cell carcinoma (SCCVII) bearing mice with the immunostimulant schizophyllan (SPG) raised the relative content of Mac-1 positive host cells infiltrating the tumor and increased photofrin retention in these tumors [4].
  • Combination treatment with cisplatin and schizophyllan for 7,12-dimethylbenz(a)anthracene-induced rat ovarian adenocarcinoma [5].

High impact information on Schizophyllan


Chemical compound and disease context of Schizophyllan


Biological context of Schizophyllan


Anatomical context of Schizophyllan


Associations of Schizophyllan with other chemical compounds


Gene context of Schizophyllan


Analytical, diagnostic and therapeutic context of Schizophyllan


  1. Combination therapy of pions and SPG (Sonifilan, Schizophyllan), a biological response modifier for mouse tumor systems. Ogawa, Y., Goodman, G.B., Chaplin, D.J., Grulkey, W., Lam, G.K. Int. J. Radiat. Oncol. Biol. Phys. (1990) [Pubmed]
  2. PEG-appended beta-(1-->3)-D-glucan schizophyllan to deliver antisense-oligonucleotides with avoiding lysosomal degradation. Karinaga, R., Koumoto, K., Mizu, M., Anada, T., Shinkai, S., Sakurai, K. Biomaterials (2005) [Pubmed]
  3. Augmentation of protective immune responses against Sendai virus infection by fungal polysaccharide schizophyllan. Hotta, H., Hagiwara, K., Tabata, K., Ito, W., Homma, M. Int. J. Immunopharmacol. (1993) [Pubmed]
  4. Potentiation of photodynamic therapy by immunotherapy: the effect of schizophyllan (SPG). Krosl, G., Korbelik, M. Cancer Lett. (1994) [Pubmed]
  5. Combination treatment with cisplatin and schizophyllan for 7,12-dimethylbenz(a)anthracene-induced rat ovarian adenocarcinoma. Sugiyama, T., Nishida, T., Kumagai, S., Imaishi, K., Ushijima, K., Kataoka, A., Yakushiji, M. Journal of obstetrics and gynaecology (Tokyo, Japan) (1995) [Pubmed]
  6. Immunomodulation and anti-cancer activity of polysaccharide-protein complexes. Ooi, V.E., Liu, F. Current medicinal chemistry. (2000) [Pubmed]
  7. Characterization of beta-glucan recognition site on C-type lectin, dectin 1. Adachi, Y., Ishii, T., Ikeda, Y., Hoshino, A., Tamura, H., Aketagawa, J., Tanaka, S., Ohno, N. Infect. Immun. (2004) [Pubmed]
  8. Beta-1,3-glucan (schizophyllan) can act as a one-dimensional host for creation of novel poly(aniline) nanofiber structures. Numata, M., Hasegawa, T., Fujisawa, T., Sakurai, K., Shinkai, S. Org. Lett. (2004) [Pubmed]
  9. Long-term expression with a cationic polymer derived from a natural polysaccharide: schizophyllan. Nagasaki, T., Hojo, M., Uno, A., Satoh, T., Koumoto, K., Mizu, M., Sakurai, K., Shinkai, S. Bioconjug. Chem. (2004) [Pubmed]
  10. Chemical modification of schizophyllan by introduction of a cationic charge into the side chain which enhances the thermal stability of schizophyllan-poly(C) complexes. Koumoto, K., Kimura, T., Mizu, M., Sakurai, K., Shinkai, S. Chem. Commun. (Camb.) (2001) [Pubmed]
  11. Lactose-appended schizophyllan is a potential candidate as a hepatocyte-targeted antisense carrier. Hasegawa, T., Umeda, M., Matsumoto, T., Numata, M., Mizu, M., Koumoto, K., Sakurai, K., Shinkai, S. Chem. Commun. (Camb.) (2004) [Pubmed]
  12. Protection of polynucleotides against nuclease-mediated hydrolysis by complexation with schizophyllan. Mizu, M., Koumoto, K., Kimura, T., Sakurai, K., Shinkai, S. Biomaterials (2004) [Pubmed]
  13. Schizophyllan-folate conjugate as a new non-cytotoxic and cancer-targeted antisense carrier. Hasegawa, T., Fujisawa, T., Haraguchi, S., Numata, M., Karinaga, R., Kimura, T., Okumura, S., Sakurai, K., Shinkai, S. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
  14. Schizophyllan (SPG)-treated macrophages and anti-tumor activities against syngeneic and allogeneic tumor cells. I. Characteristics of SPG-treated macrophages. Sugawara, I., Lee, K.C., Wong, M. Cancer Immunol. Immunother. (1984) [Pubmed]
  15. The correlation between adhesion of schizophyllan to yeast glucan and its effect on regeneration of yeast protoplast. Hisamatsu, M., Mishima, T., Teranishi, K., Yamada, T. Carbohydr. Res. (1997) [Pubmed]
  16. The effect of (1-->3)-beta-D-glucans, carboxymethylglucan and schizophyllan on human leukocytes in vitro. Kubala, L., Ruzickova, J., Nickova, K., Sandula, J., Ciz, M., Lojek, A. Carbohydr. Res. (2003) [Pubmed]
  17. Schizophyllan augments development of immunoglobulin-secreting cells upon costimulation with Staphylococcus aureus Cowan I. Shiozawa, S., Tanaka, Y., Morimoto, I., Yoshihara, R., Kuroki, Y., Fujita, T. DICP : the annals of pharmacotherapy. (1991) [Pubmed]
  18. Synergistic action of beta-glucan and platelets on interleukin-8 production by human peripheral blood leukocytes. Suzuki, T., Tsuzuki, A., Ohno, N., Ohshima, Y., Adachi, Y., Yadomae, T. Biol. Pharm. Bull. (2002) [Pubmed]
  19. Effects of an anti-tumor polysaccharide, schizophyllan, on interferon-gamma and interleukin 2 production by peripheral blood mononuclear cells. Sakagami, Y., Mizoguchi, Y., Shin, T., Seki, S., Kobayashi, K., Morisawa, S., Yamamoto, S. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
  20. Removal of the side-chain glucose groups from schizophyllan improves the thermal stability of the polycytidylic acid complexes under the physiological conditions. Koumoto, K., Karinaga, R., Mizu, M., Anada, T., Sakurai, K., Kunitake, T., Shinkai, S. Biopolymers (2004) [Pubmed]
  21. Application of Fluorescence Correlation Spectroscopy: A Study of Flocculation of Rigid Rod-like Biopolymer (Schizophyllan) and Colloidal Particles. Leng, X., Startchev, K., Buffle, J. Journal of colloid and interface science. (2002) [Pubmed]
  22. Flocculation of hematite particles by a comparatively large rigid polysaccharide: schizophyllan. Ferretti, R., Stoll, S., Zhang, J., Buffle, J. Journal of colloid and interface science. (2003) [Pubmed]
  23. Nonperturbing fluorescent labeling of polysaccharides. Meunier, F., Wilkinson, K.J. Biomacromolecules (2002) [Pubmed]
  24. Rheological characterization of schizophyllan aqueous solutions after denaturation-renaturation treatment. Fang, Y., Takahashi, R., Nishinari, K. Biopolymers (2004) [Pubmed]
  25. Soluble mannan and beta-glucan inhibit the uptake of Malassezia furfur by human monocytic cell line, THP-1. Suzuki, T., Ohno, N., Ohshima, Y., Yadomae, T. FEMS Immunol. Med. Microbiol. (1998) [Pubmed]
  26. Comparison of the carbohydrate biological response modifiers Krestin, schizophyllan and glucan phosphate by aqueous size exclusion chromatography with in-line argon-ion multi-angle laser light scattering photometry and differential viscometry detectors. Müller, A., Pretus, H.A., McNamee, R.B., Jones, E.L., Browder, I.W., Williams, D.L. J. Chromatogr. B, Biomed. Appl. (1995) [Pubmed]
  27. Macrocyclization of polysaccharides visualized by electron microscopy. Stokke, B.T., Elgsaeter, A., Kitamura, S. Int. J. Biol. Macromol. (1993) [Pubmed]
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