Disease relevance of COX1

• We have isolated and analyzed 17 clones from a bovine genomic library in phage lambda Charon28 probed with a bovine liver cDNA for cytochrome c oxidase subunit IV [1].

High impact information on COX1

• Substitutional and insertional RNA editing of the cytochrome c oxidase subunit 1 mRNA of Physarum polycephalum [2].
• Nucleotide sequence of a cDNA for bovine cytochrome c oxidase subunit VIIa [3].
• Mutation scanning analysis of mitochondrial cytochrome c oxidase subunit 1 reveals limited gene flow among bovine lungworm subpopulations in Sweden [4].
• A portion of the mitochondrial cytochrome c oxidase subunit 1 gene (pcox1) was amplified from genomic DNA isolated from individual lungworms by the polymerase chain reaction (PCR), and then subjected to single-strand conformation polymorphism (SSCP) [4].
• Tryptophan 334 oxidation in bovine cytochrome c oxidase subunit I involves free radical migration [5].

Biological context of COX1

• The amino-acid sequence of bovine heart cytochrome-c oxidase subunit I, previously deduced from mtDNA was corroborated by proteinchemical methods [6].
• Two bovine genes for cytochrome c oxidase subunit IV: a processed pseudogene and an expressed gene [1].
• Further analysis on natural selection indicated that the COXI (cytochrome c oxidase subunit I) gene was under positive selection in P. hodgsonii and Bos grunniens [7].

Anatomical context of COX1

• Switching of bovine cytochrome c oxidase subunit VIa isoforms in skeletal muscle during development [8].
• Structural organization of the bovine gene for the heart/muscle isoform of cytochrome c oxidase subunit VIa [9].

Associations of COX1 with chemical compounds

• Interaction between cardiolipin and the mitochondrial presequence of cytochrome c oxidase subunit IV favours lipid mixing without destabilizing the bilayer structure [10].

Other interactions of COX1

• The structure and expression of the gene (COX4) encoding bovine cytochrome c oxidase subunit IV (COX IV) was studied in order to identify conserved DNA sequence elements involved in the control of mammalian nuclear respiratory genes [11].
• The bovine gene for the nuclear-encoded heart/muscle isoform of cytochrome c oxidase subunit VIa (COX6A1) was isolated from a library of bovine genomic DNA in lambda EMBL3 and sequenced [9].

Analytical, diagnostic and therapeutic context of COX1

• The secondary structure of the synthetic signal peptide of cytochrome c oxidase subunit IV (coxIV-25) has been measured by circular dichroism spectroscopy in different lipid environments [12].

References