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Gene Review:

ETR101 - immediate early protein

Bos taurus

van Santen, V.L., Winkler, M.T. et al., Wirth, U.V. et al., Seal, B.S. et al., Eskra, L. et al.

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Disease relevance of ETR101

Immediate-early RNA 2.9 and early RNA 2.6 of bovine herpesvirus 1 are 3' coterminal and encode a putative zinc finger transactivator protein [1].
Immediate-early (IE) RNA 2, the less abundant of two bovine herpesvirus 4 (BHV-4) RNAs detected in Madin-Darby bovine kidney cells infected in the presence of cycloheximide, is a 1.8-kb cytoplasmic polyadenylated RNA transcribed from the 8.3-kb HindIII fragment F [2].
Immediate-early/early gene products were detected in CD4+T lymphocytes but not in infectious virions [3].

High impact information on ETR101

Immediate-early (bovine ICP0) and early (ribonucleotide reductase) transcripts were detected in PBMC and CD4(+) lymphocytes prepared from infected calves [4].

Analytical, diagnostic and therapeutic context of ETR101

Immediate-early gene expression and gene mapping comparisons among isolates of bovine herpesvirus 1 and 5 [5].

References

Immediate-early RNA 2.9 and early RNA 2.6 of bovine herpesvirus 1 are 3' coterminal and encode a putative zinc finger transactivator protein. Wirth, U.V., Fraefel, C., Vogt, B., Vlcek, C., Paces, V., Schwyzer, M. J. Virol. (1992) [Pubmed]
Characterization of a bovine herpesvirus 4 immediate-early RNA encoding a homolog of the Epstein-Barr virus R transactivator. van Santen, V.L. J. Virol. (1993) [Pubmed]
Bovine herpesvirus-1 infects activated CD4+ lymphocytes. Eskra, L., Splitter, G.A. J. Gen. Virol. (1997) [Pubmed]
Bovine herpesvirus 1 can infect CD4(+) T lymphocytes and induce programmed cell death during acute infection of cattle. Winkler, M.T., Doster, A., Jones, C. J. Virol. (1999) [Pubmed]
Immediate-early gene expression and gene mapping comparisons among isolates of bovine herpesvirus 1 and 5. Seal, B.S., Whetstone, C.A. Vet. Microbiol. (1994) [Pubmed]

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