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MeSH Review:

Herpesvirus 4, Bovine

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Disease relevance of Herpesvirus 4, Bovine

Induction of thymidine kinase activity by viruses with group B DNA genomes: bovine cytomegalovirus (bovine herpesvirus 4) [1].
Bovine herpesvirus 1 (BHV-1) isolates (Cooper-type strain 4975 and Oxford) were compared in neutralization tests with the bovine herpesvirus 4 (BHV-4) isolate (85/16 TV) and the herpesviruses of red deer (D2839/1) and goats (E/CH) [2].

High impact information on Herpesvirus 4, Bovine

All tested herpesvirus Bcl-2 homologs possess antiapoptotic activity, including the more distantly related homologs encoded by murine gammaherpesvirus 68 (gammaHV68) and bovine herpesvirus 4 (BHV4), as described here [3].
Here, we report that the bovine herpesvirus 4 (BHV4) BORFE2 gene encodes a protein that inhibits Fas- and TNFR1-induced apoptosis and contains death effector domains (DEDs) [4].
Immediate-early (IE) RNA 2, the less abundant of two bovine herpesvirus 4 (BHV-4) RNAs detected in Madin-Darby bovine kidney cells infected in the presence of cycloheximide, is a 1.8-kb cytoplasmic polyadenylated RNA transcribed from the 8.3-kb HindIII fragment F [5].
The major immediate-early (IE) RNA of bovine herpesvirus 4 (BHV-4) has been identified and characterized by analyzing cytoplasmic polyadenylated RNA isolated from Madin-Darby bovine kidney cells infected with BHV-4(DN-599) in the presence of cycloheximide [6].
Genes encoding glycoprotein gH and gL homologues were localized in the genome of the gamma-herpesvirus bovine herpesvirus-4 (BHV-4) [7].

Chemical compound and disease context of Herpesvirus 4, Bovine

This study shows that during the process of adsorption of the gammaherpesvirus bovine herpesvirus 4 (BHV-4), the viral glycoprotein gp8 interacts with heparinlike moieties of cell surface [8].
The effect of arsenite pretreatment on bovine herpesvirus-4 (BHV-4) replication in bovine arterial endothelial (BAE) cells was studied [9].
Experimental infection of bulls with a genital isolate of bovine herpesvirus-4 and reactivation of latent virus with dexamethasone [10].
In situ hybridization (ISH) protocols including different pre-treatment regimes were developed and compared for their effects on detecting bovine herpesvirus 4 (BoHV-4) in formalin fixed, paraffin embedded tissue [11].

Biological context of Herpesvirus 4, Bovine

To understand the mechanism of regulation of bovine herpesvirus 4 (BHV-4) early gene expression by immediate-early (IE) gene products, we studied activation of expression of the BHV-4 early gene encoding thymidine kinase (TK) [12].

Gene context of Herpesvirus 4, Bovine

Interaction of bovine herpesvirus 4 (BHV-4) immediate early 2 gene product with BHV-4 thymidine kinase promoter-regulatory region [12].
Infection of bovine arterial endothelial (BAE) cells with bovine herpesvirus-4 (BHV-4) induced biphasic activation of one of the cellular mitogen-activated protein kinase (MAPK) downstream targets, extracellular signal-regulated kinase (ERK) [13].
Detection of bovine herpesvirus 4 glycoprotein B and thymidine kinase DNA by PCR assays in bovine milk [14].

References

Induction of thymidine kinase activity by viruses with group B DNA genomes: bovine cytomegalovirus (bovine herpesvirus 4). Kit, S., Kit, M., Ichimura, H., Crandell, R., McConnell, S. Virus Res. (1986) [Pubmed]
A serological comparison of some animal herpesviruses. Martin, W.B., Castrucci, G., Frigeri, F., Ferrari, M. Comp. Immunol. Microbiol. Infect. Dis. (1990) [Pubmed]
Antiapoptotic herpesvirus Bcl-2 homologs escape caspase-mediated conversion to proapoptotic proteins. Bellows, D.S., Chau, B.N., Lee, P., Lazebnik, Y., Burns, W.H., Hardwick, J.M. J. Virol. (2000) [Pubmed]
Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses. Wang, G.H., Bertin, J., Wang, Y., Martin, D.A., Wang, J., Tomaselli, K.J., Armstrong, R.C., Cohen, J.I. J. Virol. (1997) [Pubmed]
Characterization of a bovine herpesvirus 4 immediate-early RNA encoding a homolog of the Epstein-Barr virus R transactivator. van Santen, V.L. J. Virol. (1993) [Pubmed]
Characterization of the bovine herpesvirus 4 major immediate-early transcript. van Santen, V.L. J. Virol. (1991) [Pubmed]
Analysis of the biochemical properties of, and complex formation between, glycoproteins H and L of the gamma2 herpesvirus bovine herpesvirus-4. Lomonte, P., Filée, P., Lyaku, J.R., Bublot, M., Pastoret, P.P., Thiry, E. J. Gen. Virol. (1997) [Pubmed]
Attachment of the gammaherpesvirus bovine herpesvirus 4 is mediated by the interaction of gp8 glycoprotein with heparinlike moieties on the cell surface. Vanderplasschen, A., Bublot, M., Dubuisson, J., Pastoret, P.P., Thiry, E. Virology (1993) [Pubmed]
Inhibition of bovine herpesvirus-4 replication in endothelial cells by arsenite. Jiang, S.J., Lin, T.M., Shi, G.Y., Eng, H.L., Chen, H.Y., Wu, H.L. Antiviral Res. (2004) [Pubmed]
Experimental infection of bulls with a genital isolate of bovine herpesvirus-4 and reactivation of latent virus with dexamethasone. Dubuisson, J., Thiry, E., Bublot, M., Thomas, I., van Bressem, M.F., Coignoul, F., Pastoret, P.P. Vet. Microbiol. (1989) [Pubmed]
Enhancement of in situ hybridization to detect bovine herpesvirus 4 in paraffin sections. Kim, O., Kwak, D. New Microbiol. (2004) [Pubmed]
Interaction of bovine herpesvirus 4 (BHV-4) immediate early 2 gene product with BHV-4 thymidine kinase promoter-regulatory region. Zhang, L., van Santen, V.L. J. Gen. Virol. (1995) [Pubmed]
Inhibition of bovine herpesvirus-4 replication by arsenite through downregulation of the extracellular signal-regulated kinase signaling pathway. Jiang, S.J., Lin, T.M., Shi, G.Y., Eng, H.L., Chen, H.Y., Wu, H.L. J. Biomed. Sci. (2004) [Pubmed]
Detection of bovine herpesvirus 4 glycoprotein B and thymidine kinase DNA by PCR assays in bovine milk. Wellenberg, G.J., Verstraten, E.R., Belák, S., Verschuren, S.B., Rijsewijk, F.A., Peshev, R., Van Oirschot, J.T. J. Virol. Methods (2001) [Pubmed]

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