Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

SLC6A8 - solute carrier family 6 (neurotransmitter...

Bos taurus

Shojaiefard, M. et al., West, M. et al.

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High impact information on SLC6A8

In Xenopus oocytes expressing SLC6A8 but not in water injected oocytes, creatine-induced a current which was significantly enhanced by coexpression of mTOR [1].
Cellular accumulation of creatine is accomplished by the Na(+), Cl(-), and creatine transporter CreaT (SLC6A8) [1].
The bovine creatine transporter (CreaT) has been purified from membranes of HEK293 cells stably expressing high levels of the transporter [2].

References

Stimulation of the creatine transporter SLC6A8 by the protein kinase mTOR. Shojaiefard, M., Christie, D.L., Lang, F. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
Purification and characterization of the creatine transporter expressed at high levels in HEK293 cells. West, M., Park, D., Dodd, J.R., Kistler, J., Christie, D.L. Protein Expr. Purif. (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

SLC6A8	Canis lupus familiaris
slc6a8	Danio rerio
SLC6A8	Homo sapiens
SLC6A8	Macaca mulatta
Slc6a8	Mus musculus
SLC6A8	Pan troglodytes
Slc6a8	Rattus norvegicus
LOC100489909	Xenopus (Silurana) tropicalis

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