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Gene Review

IL17A  -  interleukin 17A

Bos taurus

Synonyms: IL-17, IL17
 
 
 
 
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Disease relevance of IL17

  • Because levels of all these proinflammatory cytokines are raised in rheumatoid synovial fluids, this study suggests that IL17 may act as a potent upstream mediator of cartilage collagen breakdown in inflammatory joint diseases [1].
 

High impact information on IL17

  • OBJECTIVE: To investigate whether interleukin 17 (IL17), derived specifically from T cells, can promote type II collagen release from cartilage [1].
  • CONCLUSIONS: IL17 can, alone and synergistically in combination with other proinflammatory cytokines, promote chondrocyte mediated MMP dependent type II collagen release from cartilage [1].

References

  1. Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines. Koshy, P.J., Henderson, N., Logan, C., Life, P.F., Cawston, T.E., Rowan, A.D. Ann. Rheum. Dis. (2002) [Pubmed]
 
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