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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Joint Diseases

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Disease relevance of Joint Diseases


High impact information on Joint Diseases

  • All offspring develop a joint disease highly reminiscent of RA in man [6].
  • These agents also may be useful in degenerative joint disease and ankylosing spondylitis and as analgesics and antipyretics; however, there are insufficient data available to establish their efficacy and dosages for these uses [7].
  • We report here that B27 transgenic rats raised in a germfree environment do not develop inflammatory intestinal or peripheral joint disease, whereas the skin and genital inflammatory lesions are unaffected by the germfree state [8].
  • These observations implicate HBGF-1 in a multitude of biological functions in inflammatory joint diseases [9].
  • Experimental injection of hydroxyapatite crystals into dog knee joints produces inflammation supporting the potential role for these crystals in joint disease [10].

Chemical compound and disease context of Joint Diseases


Biological context of Joint Diseases


Anatomical context of Joint Diseases


Gene context of Joint Diseases


Analytical, diagnostic and therapeutic context of Joint Diseases


  1. Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints. Lark, M.W., Bayne, E.K., Flanagan, J., Harper, C.F., Hoerrner, L.A., Hutchinson, N.I., Singer, I.I., Donatelli, S.A., Weidner, J.R., Williams, H.R., Mumford, R.A., Lohmander, L.S. J. Clin. Invest. (1997) [Pubmed]
  2. Synovial fluid levels of complement SC5b-9 and fragment Bb are elevated in patients with rheumatoid arthritis. Brodeur, J.P., Ruddy, S., Schwartz, L.B., Moxley, G. Arthritis Rheum. (1991) [Pubmed]
  3. Magnetic resonance imaging-determined synovial membrane volume as a marker of disease activity and a predictor of progressive joint destruction in the wrists of patients with rheumatoid arthritis. Ostergaard, M., Hansen, M., Stoltenberg, M., Gideon, P., Klarlund, M., Jensen, K.E., Lorenzen, I. Arthritis Rheum. (1999) [Pubmed]
  4. High prevalence of IgA rheumatoid factor in severe polyarticular-onset juvenile rheumatoid arthritis, but not in systemic-onset or pauciarticular-onset disease. Walker, S.M., McCurdy, D.K., Shaham, B., Brik, R., Wietting, H., Arora, Y., Lehman, T.J., Hanson, V., Bernstein, B. Arthritis Rheum. (1990) [Pubmed]
  5. Quantitation of human synovial mast cells in rheumatoid arthritis and other rheumatic diseases. Godfrey, H.P., Ilardi, C., Engber, W., Graziano, F.M. Arthritis Rheum. (1984) [Pubmed]
  6. Organ-specific disease provoked by systemic autoimmunity. Kouskoff, V., Korganow, A.S., Duchatelle, V., Degott, C., Benoist, C., Mathis, D. Cell (1996) [Pubmed]
  7. New antirheumatic agents: Fenoprofen calcium (Nalfon), naproxen (Naprosyn), and tolmetin sodium (Tolectin). Lewis, J.R. JAMA (1977) [Pubmed]
  8. The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. Taurog, J.D., Richardson, J.A., Croft, J.T., Simmons, W.A., Zhou, M., Fernández-Sueiro, J.L., Balish, E., Hammer, R.E. J. Exp. Med. (1994) [Pubmed]
  9. Detection of high levels of heparin binding growth factor-1 (acidic fibroblast growth factor) in inflammatory arthritic joints. Sano, H., Forough, R., Maier, J.A., Case, J.P., Jackson, A., Engleka, K., Maciag, T., Wilder, R.L. J. Cell Biol. (1990) [Pubmed]
  10. Arthritis associated with apatite crystals. Schumacher, H.R., Smolyo, A.P., Tse, R.L., Maurer, K. Ann. Intern. Med. (1977) [Pubmed]
  11. Pulse methotrexate therapy in rheumatoid arthritis. A controlled prospective roentgenographic study. Nordstrom, D.M., West, S.G., Andersen, P.A., Sharp, J.T. Ann. Intern. Med. (1987) [Pubmed]
  12. Antibodies against crystals. Kam, M., Perl-Treves, D., Caspi, D., Addadi, L. FASEB J. (1992) [Pubmed]
  13. Quantitation of chondroitin 4-sulfate and chondroitin 6-sulfate in pathologic joint fluid. Shinmei, M., Miyauchi, S., Machida, A., Miyazaki, K. Arthritis Rheum. (1992) [Pubmed]
  14. Noradrenergic and peptidergic nerves in the synovial membrane of the Sprague-Dawley rat. Bjurholm, A., Kreicbergs, A., Ahmed, M., Schultzberg, M. Arthritis Rheum. (1990) [Pubmed]
  15. Aseptic arthritis in a man with toxic shock syndrome. Gertner, E., Inman, R.D. Arthritis Rheum. (1986) [Pubmed]
  16. Targeted disruption of Mig-6 in the mouse genome leads to early onset degenerative joint disease. Zhang, Y.W., Su, Y., Lanning, N., Swiatek, P.J., Bronson, R.T., Sigler, R., Martin, R.W., Vande Woude, G.F. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  17. JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression. Legendre, F., Dudhia, J., Pujol, J.P., Bogdanowicz, P. J. Biol. Chem. (2003) [Pubmed]
  18. Anticoagulant properties of three mucopolysaccharides used in rheumatology. Bauer, F., Schulz, P., Reber, G., Bouvier, C.A. Thromb. Haemost. (1983) [Pubmed]
  19. Epidemiological characteristics of childhood acute lymphocytic leukemia. Analysis by immunophenotype. The Childrens Cancer Group. Buckley, J.D., Buckley, C.M., Ruccione, K., Sather, H.N., Waskerwitz, M.J., Woods, W.G., Robison, L.L. Leukemia (1994) [Pubmed]
  20. Articular chondrocytes from animals with a dermatan sulfate storage disease undergo a high rate of apoptosis and release nitric oxide and inflammatory cytokines: a possible mechanism underlying degenerative joint disease in the mucopolysaccharidoses. Simonaro, C.M., Haskins, M.E., Schuchman, E.H. Lab. Invest. (2001) [Pubmed]
  21. Circulating and intra-articular immune complexes in patients with rheumatoid arthritis. Correlation of 125I-Clq binding activity with clinical and biological features of the disease. Zubler, R.H., Nydegger, U., Perrin, L.H., Fehr, K., McCormick, J., Lambert, P.H., Miescher, P.A. J. Clin. Invest. (1976) [Pubmed]
  22. Clonal dominance among T-lymphocyte infiltrates in arthritis. Stamenkovic, I., Stegagno, M., Wright, K.A., Krane, S.M., Amento, E.P., Colvin, R.B., Duquesnoy, R.J., Kurnick, J.T. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  23. Critical role for granulocyte colony-stimulating factor in inflammatory arthritis. Lawlor, K.E., Campbell, I.K., Metcalf, D., O'Donnell, K., van Nieuwenhuijze, A., Roberts, A.W., Wicks, I.P. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  24. Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis. Okamoto, K., Makino, S., Yoshikawa, Y., Takaki, A., Nagatsuka, Y., Ota, M., Tamiya, G., Kimura, A., Bahram, S., Inoko, H. Am. J. Hum. Genet. (2003) [Pubmed]
  25. Local proliferation of fibroblast-like synoviocytes contributes to synovial hyperplasia. Results of proliferating cell nuclear antigen/cyclin, c-myc, and nucleolar organizer region staining. Qu, Z., Garcia, C.H., O'Rourke, L.M., Planck, S.R., Kohli, M., Rosenbaum, J.T. Arthritis Rheum. (1994) [Pubmed]
  26. Mutations in ANKH cause chondrocalcinosis. Pendleton, A., Johnson, M.D., Hughes, A., Gurley, K.A., Ho, A.M., Doherty, M., Dixey, J., Gillet, P., Loeuille, D., McGrath, R., Reginato, A., Shiang, R., Wright, G., Netter, P., Williams, C., Kingsley, D.M. Am. J. Hum. Genet. (2002) [Pubmed]
  27. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor alpha in rheumatoid arthritis. Arend, W.P., Dayer, J.M. Arthritis Rheum. (1995) [Pubmed]
  28. Estradiol represses human T-cell leukemia virus type 1 Tax activation of tumor necrosis factor-alpha gene transcription. Tzagarakis-Foster, C., Geleziunas, R., Lomri, A., An, J., Leitman, D.C. J. Biol. Chem. (2002) [Pubmed]
  29. Expression of cyclooxygenase 1 and cyclooxygenase 2 in human synovial tissue: differential elevation of cyclooxygenase 2 in inflammatory joint diseases. Siegle, I., Klein, T., Backman, J.T., Saal, J.G., Nüsing, R.M., Fritz, P. Arthritis Rheum. (1998) [Pubmed]
  30. Activation of nuclear orphan receptor NURR1 transcription by NF-kappa B and cyclic adenosine 5'-monophosphate response element-binding protein in rheumatoid arthritis synovial tissue. McEvoy, A.N., Murphy, E.A., Ponnio, T., Conneely, O.M., Bresnihan, B., FitzGerald, O., Murphy, E.P. J. Immunol. (2002) [Pubmed]
  31. Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis. Takagi, N., Mihara, M., Moriya, Y., Nishimoto, N., Yoshizaki, K., Kishimoto, T., Takeda, Y., Ohsugi, Y. Arthritis Rheum. (1998) [Pubmed]
  32. Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy. Otani, K., Nita, I., Macaulay, W., Georgescu, H.I., Robbins, P.D., Evans, C.H. J. Immunol. (1996) [Pubmed]
  33. Reduced joint count indices in the evaluation of rheumatoid arthritis. Egger, M.J., Huth, D.A., Ward, J.R., Reading, J.C., Williams, H.J. Arthritis Rheum. (1985) [Pubmed]
  34. Six-week, double-blind, placebo-controlled and long-term, open-label multicenter study of isoxicam in treatment of degenerative joint disease. Posner, S.L. Am. J. Med. (1985) [Pubmed]
  35. Pro-MMP-9 is a specific macrophage product and is activated by osteoarthritic chondrocytes via MMP-3 or a MT1-MMP/MMP-13 cascade. Dreier, R., Grässel, S., Fuchs, S., Schaumburger, J., Bruckner, P. Exp. Cell Res. (2004) [Pubmed]
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