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Gene Review

IL17A  -  interleukin 17A

Homo sapiens

Synonyms: CTLA-8, CTLA8, Cytotoxic T-lymphocyte-associated antigen 8, IL-17, IL-17A, ...
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Disease relevance of IL17A


Psychiatry related information on IL17A

  • Analyses by ELISA showed that IL-17 protein was undetectable in 48.6% of the patients with cancer, as well as corresponding normal tissue which may in part reflect an individual difference [7].

High impact information on IL17A


Chemical compound and disease context of IL17A


Biological context of IL17A

  • These observations suggest that hIL-17 may constitute (a) an early initiator of the T cell-dependent inflammmatory reaction; and (b) an element of the cytokine network that bridges the immune system to hematopoiesis [2].
  • Furthermore, transfection studies using a luciferase-driven reporter construct containing eotaxin-1/CCL11 proximal promoter showed that IL-17A induced eotaxin-1/CCL11 at the transcriptional level [16].
  • RESULTS: Compared with IFN-gamma, CM of either cell type stimulated with IL-1beta, or in the case of HCE cells, stimulated with TNF-alpha or IL-17, delayed neutrophil apoptosis significantly [17].
  • Further, IL-17 induced the phosphorylation of src kinase and mitogen-activated protein (MAP) kinase [18].
  • Collectively, we have identified IL-22 as a new cytokine expressed by Th17 cells that synergizes with IL-17A or IL-17F to regulate genes associated with skin innate immunity [19].

Anatomical context of IL17A


Associations of IL17A with chemical compounds


Physical interactions of IL17A

  • Binding studies suggest that recombinant hIL-17 binds to the hIL-17R with low affinity [24].

Regulatory relationships of IL17A

  • This effect of hIL-17 was inhibited by cotreatment with an anti-hIL-17 Ab and was potentiated by hTNF-alpha [20].
  • IL-6 secretion was rapidly induced by IL-17, IL-1beta, and TNF-alpha [25].
  • We conclude that CO inhibits IL-17-stimulated inflammatory response via the ERK1/2-dependent pathway [26].
  • Pharmacological drugs used in therapy of RA, such as cyclosporin and methotrexate, induced a fourfold increase of IL-17R mRNA expression and augmented the IL-17-stimulated IL-8 expression [27].
  • In this study, we investigated the effects of IL-17 on colony-stimulating factor (CSF) release in human colonic subepithelial myofibroblasts (SEMFs) [28].
  • CCR6 was likewise expressed on all IL-17-producing CD8+ PBL [29].

Other interactions of IL17A


Analytical, diagnostic and therapeutic context of IL17A


  1. Association analysis of the interleukin 17 genes IL17A and IL17F as potential osteoarthritis susceptibility loci. Southam, L., Heath, O., Chapman, K., Loughlin, J. Ann. Rheum. Dis. (2006) [Pubmed]
  2. T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. Fossiez, F., Djossou, O., Chomarat, P., Flores-Romo, L., Ait-Yahia, S., Maat, C., Pin, J.J., Garrone, P., Garcia, E., Saeland, S., Blanchard, D., Gaillard, C., Das Mahapatra, B., Rouvier, E., Golstein, P., Banchereau, J., Lebecque, S. J. Exp. Med. (1996) [Pubmed]
  3. Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis. McAllister, F., Henry, A., Kreindler, J.L., Dubin, P.J., Ulrich, L., Steele, C., Finder, J.D., Pilewski, J.M., Carreno, B.M., Goldman, S.J., Pirhonen, J., Kolls, J.K. J. Immunol. (2005) [Pubmed]
  4. IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts. Maertzdorf, J., Osterhaus, A.D., Verjans, G.M. J. Immunol. (2002) [Pubmed]
  5. Interleukin-11 and IL-17 and the pathogenesis of periodontal disease. Johnson, R.B., Wood, N., Serio, F.G. J. Periodontol. (2004) [Pubmed]
  6. Different T cell subsets in the nodule and synovial membrane: absence of interleukin-17A in rheumatoid nodules. Stamp, L.K., Easson, A., Lehnigk, U., Highton, J., Hessian, P.A. Arthritis Rheum. (2008) [Pubmed]
  7. Expression of interleukin-17 in human colorectal cancer. W??gs??ter, D., L??fgren, S., Hugander, A., Dimberg, J. Anticancer Res. (2006) [Pubmed]
  8. IL-17 Family Cytokines and the Expanding Diversity of Effector T Cell Lineages. Weaver, C.T., Hatton, R.D., Mangan, P.R., Harrington, L.E. Annu. Rev. Immunol. (2007) [Pubmed]
  9. Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation. Laurence, A., Tato, C.M., Davidson, T.S., Kanno, Y., Chen, Z., Yao, Z., Blank, R.B., Meylan, F., Siegel, R., Hennighausen, L., Shevach, E.M., O'shea, J.J. Immunity (2007) [Pubmed]
  10. Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Uhlig, H.H., McKenzie, B.S., Hue, S., Thompson, C., Joyce-Shaikh, B., Stepankova, R., Robinson, N., Buonocore, S., Tlaskalova-Hogenova, H., Cua, D.J., Powrie, F. Immunity (2006) [Pubmed]
  11. Interleukin-17 family members and inflammation. Kolls, J.K., Lindén, A. Immunity (2004) [Pubmed]
  12. High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism. Ziolkowska, M., Koc, A., Luszczykiewicz, G., Ksiezopolska-Pietrzak, K., Klimczak, E., Chwalinska-Sadowska, H., Maslinski, W. J. Immunol. (2000) [Pubmed]
  13. Th1 shift in CIDP versus Th2 shift in vasculitic neuropathy in CSF. Mei, F.J., Ishizu, T., Murai, H., Osoegawa, M., Minohara, M., Zhang, K.N., Kira, J. J. Neurol. Sci. (2005) [Pubmed]
  14. IL-11 and IL-17 expression in nasal polyps: relationship to collagen deposition and suppression by intranasal fluticasone propionate. Molet, S.M., Hamid, Q.A., Hamilos, D.L. Laryngoscope (2003) [Pubmed]
  15. Inoculation of human interleukin-17 gene-transfected Meth-A fibrosarcoma cells induces T cell-dependent tumor-specific immunity in mice. Hirahara, N., Nio, Y., Sasaki, S., Minari, Y., Takamura, M., Iguchi, C., Dong, M., Yamasawa, K., Tamura, K. Oncology (2001) [Pubmed]
  16. IL-17A Induces Eotaxin-1/CC Chemokine Ligand 11 Expression in Human Airway Smooth Muscle Cells: Role of MAPK (Erk1/2, JNK, and p38) Pathways. Rahman, M.S., Yamasaki, A., Yang, J., Shan, L., Halayko, A.J., Gounni, A.S. J. Immunol. (2006) [Pubmed]
  17. Granulocyte Macrophage Colony-Stimulating Factor Expression in Human Herpetic Stromal Keratitis: Implications for the Role of Neutrophils in HSK. Duan, R., Remeijer, L., van Dun, J.M., Osterhaus, A.D., Verjans, G.M. Invest. Ophthalmol. Vis. Sci. (2007) [Pubmed]
  18. Interleukin-17 induces src/MAPK cascades activation in human renal epithelial cells. Hsieh, H.G., Loong, C.C., Lin, C.Y. Cytokine (2002) [Pubmed]
  19. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. Liang, S.C., Tan, X.Y., Luxenberg, D.P., Karim, R., Dunussi-Joannopoulos, K., Collins, M., Fouser, L.A. J. Exp. Med. (2006) [Pubmed]
  20. Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. Laan, M., Cui, Z.H., Hoshino, H., Lötvall, J., Sjöstrand, M., Gruenert, D.C., Skoogh, B.E., Lindén, A. J. Immunol. (1999) [Pubmed]
  21. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. Kotake, S., Udagawa, N., Takahashi, N., Matsuzaki, K., Itoh, K., Ishiyama, S., Saito, S., Inoue, K., Kamatani, N., Gillespie, M.T., Martin, T.J., Suda, T. J. Clin. Invest. (1999) [Pubmed]
  22. IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. Hymowitz, S.G., Filvaroff, E.H., Yin, J.P., Lee, J., Cai, L., Risser, P., Maruoka, M., Mao, W., Foster, J., Kelley, R.F., Pan, G., Gurney, A.L., de Vos, A.M., Starovasnik, M.A. EMBO J. (2001) [Pubmed]
  23. Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB. Shalom-Barak, T., Quach, J., Lotz, M. J. Biol. Chem. (1998) [Pubmed]
  24. Molecular characterization of the human interleukin (IL)-17 receptor. Yao, Z., Spriggs, M.K., Derry, J.M., Strockbine, L., Park, L.S., VandenBos, T., Zappone, J.D., Painter, S.L., Armitage, R.J. Cytokine (1997) [Pubmed]
  25. IL-6 secretion by human pancreatic periacinar myofibroblasts in response to inflammatory mediators. Shimada, M., Andoh, A., Hata, K., Tasaki, K., Araki, Y., Fujiyama, Y., Bamba, T. J. Immunol. (2002) [Pubmed]
  26. Carbon monoxide inhibits IL-17-induced IL-6 production through the MAPK pathway in human pulmonary epithelial cells. Ning, W., Choi, A.M., Li, C. Am. J. Physiol. Lung Cell Mol. Physiol. (2005) [Pubmed]
  27. Expression, modulation and signalling of IL-17 receptor in fibroblast-like synoviocytes of patients with rheumatoid arthritis. Kehlen, A., Thiele, K., Riemann, D., Langner, J. Clin. Exp. Immunol. (2002) [Pubmed]
  28. Interleukin-17 augments tumor necrosis factor-alpha-induced granulocyte and granulocyte/macrophage colony-stimulating factor release from human colonic myofibroblasts. Andoh, A., Yasui, H., Inatomi, O., Zhang, Z., Deguchi, Y., Hata, K., Araki, Y., Tsujikawa, T., Kitoh, K., Kim-Mitsuyama, S., Takayanagi, A., Shimizu, N., Fujiyama, Y. J. Gastroenterol. (2005) [Pubmed]
  29. Human T cells that are able to produce IL-17 express the chemokine receptor CCR6. Singh, S.P., Zhang, H.H., Foley, J.F., Hedrick, M.N., Farber, J.M. J. Immunol. (2008) [Pubmed]
  30. Interleukin-17 induces hyperresponsive interleukin-8 and interleukin-6 production to tumor necrosis factor-alpha in structural lung cells. van den Berg, A., Kuiper, M., Snoek, M., Timens, W., Postma, D.S., Jansen, H.M., Lutter, R. Am. J. Respir. Cell Mol. Biol. (2005) [Pubmed]
  31. IL-17 and IL-17F modulate GM-CSF production by lung microvascular endothelial cells stimulated with IL-1beta and/or TNF-alpha. Numasaki, M., Tomioka, Y., Takahashi, H., Sasaki, H. Immunol. Lett. (2004) [Pubmed]
  32. Cooperation of interleukin-17 and interferon-gamma on chemokine secretion in human fetal intestinal epithelial cells. Andoh, A., Takaya, H., Makino, J., Sato, H., Bamba, S., Araki, Y., Hata, K., Shimada, M., Okuno, T., Fujiyama, Y., Bamba, T. Clin. Exp. Immunol. (2001) [Pubmed]
  33. Expression and function of pro-inflammatory interleukin IL-17 and IL-17 receptor in normal, benign hyperplastic, and malignant prostate. Steiner, G.E., Newman, M.E., Paikl, D., Stix, U., Memaran-Dagda, N., Lee, C., Marberger, M.J. Prostate (2003) [Pubmed]
  34. Extracellular signal-regulated protein kinase mediates interleukin 17 (IL-17)-induced IL-8 secretion in Helicobacter pylori-infected human gastric epithelial cells. Sebkova, L., Pellicanò, A., Monteleone, G., Grazioli, B., Guarnieri, G., Imeneo, M., Pallone, F., Luzza, F. Infect. Immun. (2004) [Pubmed]
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