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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SLC39A5  -  solute carrier family 39 (zinc...

Homo sapiens

Synonyms: LZT-Hs7, MYP24, Solute carrier family 39 member 5, ZIP-5, ZIP5, ...
 
 
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Disease relevance of SLC39A5

  • The ZIP5 gene encodes a protein closely related to ZIP4, a zinc transporter mutated in the human genetic disorder acrodermatitis enteropathica [1].
 

High impact information on SLC39A5

  • Furthermore, given its expression in tissues important to zinc homeostasis, we propose that Zip5 plays a central role in controlling organismal zinc status [2].
  • In this study, we present evidence that mouse Zip5 is a zinc uptake transporter that is specific for Zn(II) over other potential metal ion substrates [2].
  • Immunohistochemistry localizes ZIP5 to the basolateral surfaces of enterocytes, acinar cells, and visceral endoderm cells in mice fed a zinc-adequate diet [1].

References

  1. The adaptive response to dietary zinc in mice involves the differential cellular localization and zinc regulation of the zinc transporters ZIP4 and ZIP5. Dufner-Beattie, J., Kuo, Y.M., Gitschier, J., Andrews, G.K. J. Biol. Chem. (2004) [Pubmed]
  2. The mammalian Zip5 protein is a zinc transporter that localizes to the basolateral surface of polarized cells. Wang, F., Kim, B.E., Petris, M.J., Eide, D.J. J. Biol. Chem. (2004) [Pubmed]
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