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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Acrodermatitis


Psychiatry related information on Acrodermatitis


High impact information on Acrodermatitis


Chemical compound and disease context of Acrodermatitis


Biological context of Acrodermatitis


Anatomical context of Acrodermatitis

  • However, the sensitivity for IgG in sera from patients with acrodermatitis chronica atrophicans (n = 20) was high in both assays: 90% in the sonicate EIA compared to 95% in the flagellum EIA [22].
  • Oligonucleotide primers used in the reaction flank a 244-base-pair representing part of the variable region V4 of the B. burgdorferi 16S rRNA from biopsies of patients with acrodermatitis, and in synovial fluid from a dog with arthritis [23].
  • Tissue typing performed on the lymphocytes of 41 patients, including: 23 patients with ichthyosis (15 of autosomal dominant and 8 of the x-linked variety; 8 patients with tuberous sclerosis (epiloia); and 10 patients with acrodermatitis enteropathica (AEP) [24].

Gene context of Acrodermatitis

  • We also report the mutational analysis of human SLC30A4 in ten families with acrodermatitis enteropathica, which enabled us to exclude this gene from any involvement in the disorder of the patients examined [25].
  • Acrodermatitis enteropathica mutations affect transport activity, localization and zinc-responsive trafficking of the mouse ZIP4 zinc transporter [26].
  • Four groups of children were tested for the distribution of C3 and BF phenotypes: HBV-infected patients with Gianotti-Crosti syndrome, with CAH and with glomerulonephritis, and healthy children [27].
  • The successful use of etanercept in combination therapy for treatment of acrodermatitis continua of hallopeau [28].
  • The ZIP5 gene encodes a protein closely related to ZIP4, a zinc transporter mutated in the human genetic disorder acrodermatitis enteropathica [29].

Analytical, diagnostic and therapeutic context of Acrodermatitis


  1. No evidence for Borrelia burgdorferi-specific DNA in lesions of localized scleroderma. Wienecke, R., Schlüpen, E.M., Zöchling, N., Neubert, U., Meurer, M., Volkenandt, M. J. Invest. Dermatol. (1995) [Pubmed]
  2. Scored antibody reactivity determined by immunoblotting shows an association between clinical manifestations and presence of Borrelia burgdorferi sensu stricto, B. garinii, B. afzelii, and B. Valaisiana in humans. Ryffel, K., Péter, O., Rutti, B., Suard, A., Dayer, E. J. Clin. Microbiol. (1999) [Pubmed]
  3. A case of acrodermatitis enteropathica-like dermatosis caused by ornithine transcarbamylase deficiency. Lee, J.Y., Chang, S.E., Suh, C.W., Choi, J.H., Sung, K.J., Moon, K.C., Koh, J.K. J. Am. Acad. Dermatol. (2002) [Pubmed]
  4. Inborn errors of biotin metabolism. Nyhan, W.L. Archives of dermatology. (1987) [Pubmed]
  5. Borrelia burgdorferi in the nervous system: the new "great imitator". Pachner, A.R. Ann. N. Y. Acad. Sci. (1988) [Pubmed]
  6. Interactions between zinc, essential fatty acids and prostaglandins: relevance to acrodermatitis enteropathica, total parenteral nutrition, the glucagonoma syndrome, diabetes, anorexia nervosa and sickle cell anaemia. Horrobin, D.F., Cunnane, S.C. Med. Hypotheses (1980) [Pubmed]
  7. Zinc and the central nervous system. Wallwork, J.C. Progress in food & nutrition science. (1987) [Pubmed]
  8. Identification of SLC39A4, a gene involved in acrodermatitis enteropathica. Küry, S., Dréno, B., Bézieau, S., Giraudet, S., Kharfi, M., Kamoun, R., Moisan, J.P. Nat. Genet. (2002) [Pubmed]
  9. Zinc deficiency in murine milk underlies expression of the lethal milk (lm) mutation. Piletz, J.E., Ganschow, R.E. Science (1978) [Pubmed]
  10. Zinc citrate, human milk, and acrodermatitis enteropathica. Hurley, L.S., Lonnerdal, B., Stanislowski, A.G. Lancet (1979) [Pubmed]
  11. Defective prostaglandin synthesis in acrodermatitis enteropathica. Evans, G.W., Johnson, P.E. Lancet (1977) [Pubmed]
  12. Zinc sulphate for acrodermatitis enteropathica. Guiraldes, E., Sorensen, R., Gutierrez, C., Cofre, P., Gonzalez, B. Lancet (1975) [Pubmed]
  13. Letter: Zinc and diodoquin in acrodermatitis enteropathica. Portnoy, B., Molokhia, M. Lancet (1975) [Pubmed]
  14. Severe zinc deficiency in humans: association with a reversible T-lymphocyte dysfunction. Allen, J.I., Kay, N.E., McClain, C.J. Ann. Intern. Med. (1981) [Pubmed]
  15. The effects of diet and zinc treatment on the fatty acid composition of serum lipids and adipose tissue and on serum lipoproteins in two adolescent patients with acrodermatitis enteropathica. Walldius, G., Michaëlsson, G., Hardell, L.I., Aberg, H. Am. J. Clin. Nutr. (1983) [Pubmed]
  16. Neurotoxicity of halogenated hydroxyquinolines: clinical analysis of cases reported outside Japan. Baumgartner, G., Gawel, M.J., Kaeser, H.E., Pallis, C.A., Rose, F.C., Schaumburg, H.H., Thomas, P.K., Wadia, N.H. J. Neurol. Neurosurg. Psychiatr. (1979) [Pubmed]
  17. Zinc absorption in cattle with a dietary picolinic acid supplement. Flagstad, T. J. Nutr. (1981) [Pubmed]
  18. Phenotypes indicating cytolytic properties of Borrelia-specific interferon-gamma secreting cells in chronic Lyme neuroborreliosis. Ekerfelt, C., Jarefors, S., Tynngård, N., Hedlund, M., Sander, B., Bergström, S., Forsberg, P., Ernerudh, J. J. Neuroimmunol. (2003) [Pubmed]
  19. Clioquinol-zinc chelate: a candidate causative agent of subacute myelo-optic neuropathy. Arbiser, J.L., Kraeft, S.K., van Leeuwen, R., Hurwitz, S.J., Selig, M., Dickersin, G.R., Flint, A., Byers, H.R., Chen, L.B. Mol. Med. (1998) [Pubmed]
  20. Zinc deficiency manifested by dermatitis and visual dysfunction in a patient with Crohn's disease. Myung, S.J., Yang, S.K., Jung, H.Y., Jung, S.A., Kang, G.H., Ha, H.K., Hong, W.S., Min, Y.I. J. Gastroenterol. (1998) [Pubmed]
  21. Polymerase chain reaction in diagnosis of Borrelia burgdorferi infections and studies on taxonomic classification. Lebech, A.M. APMIS Suppl. (2002) [Pubmed]
  22. Comparison of flagellum and sonicate antigens for serological diagnosis of Lyme borreliosis. Karlsson, M., Stiernstedt, G., Granström, M., Asbrink, E., Wretlind, B. Eur. J. Clin. Microbiol. Infect. Dis. (1990) [Pubmed]
  23. Detection of Borrelia burgdorferi DNA in human skin biopsies and dog synovial fluid by the polymerase chain reaction. Salinas-Meléndez, J.A., Tamez-González, R., Welsh-Lozano, O., Barrera-Saldaãna, H.A. Rev. Latinoam. Microbiol. (1995) [Pubmed]
  24. Human leukocyte antigen in genodermatosis. Amer, M., Afifi, N., Iskander, I., Diab, N. International journal of dermatology. (1984) [Pubmed]
  25. Expression pattern, genomic structure and evaluation of the human SLC30A4 gene as a candidate for acrodermatitis enteropathica. Küry, S., Devilder, M.C., Avet-Loiseau, H., Dreno, B., Moisan, J.P. Hum. Genet. (2001) [Pubmed]
  26. Acrodermatitis enteropathica mutations affect transport activity, localization and zinc-responsive trafficking of the mouse ZIP4 zinc transporter. Wang, F., Kim, B.E., Dufner-Beattie, J., Petris, M.J., Andrews, G., Eide, D.J. Hum. Mol. Genet. (2004) [Pubmed]
  27. Frequency of complement third component (C3) and properdin factor (BF) phenotypes in patients with various clinical manifestations of HBV infection. Kacprzak-Bergman, I., Halasa, J. Eur. J. Immunogenet. (1996) [Pubmed]
  28. The successful use of etanercept in combination therapy for treatment of acrodermatitis continua of hallopeau. Kazinski, K., Joyce, K.M., Hodson, D. Journal of drugs in dermatology : JDD. (2005) [Pubmed]
  29. The adaptive response to dietary zinc in mice involves the differential cellular localization and zinc regulation of the zinc transporters ZIP4 and ZIP5. Dufner-Beattie, J., Kuo, Y.M., Gitschier, J., Andrews, G.K. J. Biol. Chem. (2004) [Pubmed]
  30. Protracted diarrhoea: secondary monosaccharide malabsorption and zinc deficiency with cutaneous manifestations during total parenteral nutrition. Stern, M., Grüttner, R., Krumbach, J. Eur. J. Pediatr. (1980) [Pubmed]
  31. Success and failure in the treatment of acrodermatitis chronica atrophicans. Aberer, E., Breier, F., Stanek, G., Schmidt, B. Infection (1996) [Pubmed]
  32. Polymerase chain reaction control of antibiotic treatment in dermatoborreliosis. Muellegger, R., Zoechling, N., Schluepen, E.M., Soyer, H.P., Hoedl, S., Kerl, n.u.l.l., Volkenandt, M. Infection (1996) [Pubmed]
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