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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GPR18  -  G protein-coupled receptor 18

Homo sapiens

Synonyms: G-protein coupled receptor 18, GPCRW, N-arachidonyl glycine receptor, NAGly receptor
 
 
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High impact information on GPR18

  • EBI2 clustered with the orphan GPR18 by alignment analysis as well as by close proximity in the chromosomal region 13q32 [1].
  • GPR18 was expressed significantly in lymphoid cell lines, but not in non-lymphoid hematopoietic cell lines [2].
  • An orphan G-protein-coupled receptor, GPR18, was cloned on the basis of degenerate-oligonucleotide PCR analysis of HUT 102 cells using primers designed from the conservative regions of the human chemokine receptor [2].

References

  1. Molecular Pharmacological Phenotyping of EBI2: AN ORPHAN SEVEN-TRANSMEMBRANE RECEPTOR WITH CONSTITUTIVE ACTIVITY. Rosenkilde, M.M., Benned-Jensen, T., Andersen, H., Holst, P.J., Kledal, T.N., Lüttichau, H.R., Larsen, J.K., Christensen, J.P., Schwartz, T.W. J. Biol. Chem. (2006) [Pubmed]
  2. Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18. Kohno, M., Hasegawa, H., Inoue, A., Muraoka, M., Miyazaki, T., Oka, K., Yasukawa, M. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
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