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Gene Review

RSPO1  -  R-spondin 1

Homo sapiens

Synonyms: CRISTIN3, FLJ40906, R-spondin-1, RSPO, RSPONDIN, ...
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Disease relevance of RSPO1

  • Here we show that human R-spondin1 (RSPO1) is the gene disrupted in a recessive syndrome characterized by XX sex reversal, palmoplantar hyperkeratosis and predisposition to squamous cell carcinoma of the skin [1].
  • In a general functional screen for human secreted proteins using transgenic mouse models, we identified human R-spondin1 (hRspo1) protein as a potent and specific mitogen for the gastrointestinal epithelium and demonstrated a potential therapeutic application for the protein in mouse models of cancer therapy-induced mucositis [2].

High impact information on RSPO1

  • The solid dispersions were produced by melting and solvent methods, containing 7%, 15%, or 25% of the drug and different ratios of Eudragit RLPO and RSPO in ratios of 0:10, 3:7, 5:5, 7:3, and 10:0 [3].
  • Extended-release theophylline (TP) matrix tablets were prepared by direct compression of drug and different pH-dependent (Eudragit L100, S100 and L100-55) and pH-independent (Eudragit RLPO and RSPO) polymer combinations [4].
  • Several new 17beta-estradiol unilaminate adhesive devices capable of releasing 17beta-estradiol in a controlled fashion over a 24-h, 36-h, 96-h, 104-h, 168-h, and 216-h period have been developed using acrylic resins (Eudragits E100, RSPO, and RLPO) as adhesive and rate-controlling polymers [5].


  1. R-spondin1 is essential in sex determination, skin differentiation and malignancy. Parma, P., Radi, O., Vidal, V., Chaboissier, M.C., Dellambra, E., Valentini, S., Guerra, L., Schedl, A., Camerino, G. Nat. Genet. (2006) [Pubmed]
  2. R-Spondin proteins: a novel link to beta-catenin activation. Kim, K.A., Zhao, J., Andarmani, S., Kakitani, M., Oshima, T., Binnerts, M.E., Abo, A., Tomizuka, K., Funk, W.D. Cell Cycle (2006) [Pubmed]
  3. Preparation and characterization of metoprolol controlled-release solid dispersions. Varshosaz, J., Faghihian, H., Rastgoo, K. Drug delivery. (2006) [Pubmed]
  4. Influence of formulation and process variables on in vitro release of theophylline from directly-compressed Eudragit matrix tablets. Ceballos, A., Cirri, M., Maestrelli, F., Corti, G., Mura, P. Farmaco (2005) [Pubmed]
  5. Acrylic resins as rate-controlling membranes in novel formulation of a nine-day 17beta-estradiol transdermal delivery system: in vitro and release modifier effect evaluation. Rafiee-Tehrani, M., Safaii-Nikui, N., Peteriet, H., Beckert, T. Drug development and industrial pharmacy. (2001) [Pubmed]
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