Disease relevance of Methylmethacrylate

• It is concluded that oral 5-ASA coated with Eudragit S (Rohn Pharma GmbH, Wieterstadt, Germany), 2.4 g daily, is safe and seems superior to placebo in preventing or delaying clinical relapse in Crohn's disease, especially in milder cases and in ileal disease [1].
• Round 13-mm discs of methylmethacrylate implanted S.C. in A/BiF/F50 + mice produced sarcomas in 12 percent of mice at 64 weeks [2].
• The treatment of 31 actual or pending pathologic fractures of the long bones with open reduction and internal fixation with methylmethacrylate in 25 patients with intraosseous metastatic breast cancer is reported [3].
• The aneurysm cavities and adjacent vessels were embedded in methylmethacrylate, were sectioned, and were stained for histologic examination [4].
• METHODS: Entheses were removed from 29 different sites in the limbs of formalin fixed, elderly, dissecting room cadavers and the samples prepared for paraffin and/or methylmethacrylate histology [5].

Psychiatry related information on Methylmethacrylate

• In week 17 oral therapy started: Gr.3 and 6: 60mg Eudragit/kg body weight/d (vehicle of MMPI), Gr.7 and 8: 40mg, respectively, 120mg RO 28-2653/kg body weight/d; Gr.1, 2, 4, 5: no therapy [6].

High impact information on Methylmethacrylate

• Mesalamine microgranular preparation was a gelatin capsule containing 400 mg of mesalamine microgranules coated with Eudragit S, which has been shown to deliver the drug in the terminal ileum [7].
• Reduction in myocardial temperature and heart rate by means of reduction in perfusate temperature of the isolated hearts reduced the myocardial depressant effect of methylmethacrylate [8].
• The optic nerve and peripapillary choroidal vessels were sequentially microdissected, using methylmethacrylate corrosion microvascular castings, and were examined with a scanning electron microscope to determine the three-dimensional relationships of the vessels [9].
• Intraocular connections of these vessels were then documented with scanning electron microscopy of methylmethacrylate microvascular luminal castings [10].
• The antibody powders were obtained by spray drying the water-soluble protein fraction of egg yolks from immunized hens after the lipid components were precipitated with an aqueous dispersion of acrylic resins (Eudragit L30D-55; Rohm pharma) [11].

Chemical compound and disease context of Methylmethacrylate

• Five types of these novel microspheres, two made of poly(styrene) and hemisuccinated poly(vinyl alcohol) (A4 and A7), and three made of poly(methyl methacrylate) and Eudragit L100/55 (1D, 1E, H1D), differing for chemical composition, size, and surface charge density were analyzed for the delivery of the HIV-1 Tat protein for vaccine applications [12].
• Three dentin bonding agents (Prisma Universal Bond, Pertac Universal Bond, and Syntac) and the ingredients methylmethacrylate, 2-hydroxyethyl-methacrylate, and glutaraldehyde were investigated in the Salmonella typhimurium mutagenicity test system using five different bacterial strains (TA97a, TA98, TA100, TA102, and TA104) [13].
• Weight loss of the Eudragit E film plasticized with triacetin or DEP was more pronounced with aging, but when plasticized with DBP or TBC weight loss was not seen [14].
• Percutaneous injection of methylmethacrylate or ethanol may provide marked pain relief or bone strengthening in patients with malignant acetabular osteolyses who are unable to tolerate surgery [15].
• 0. For Eudragit L100-55, which could form films at lower TEC levels than Eudragit S100:L100, both the organic and aqueous films showed the same weight loss after four hours in pH 5.0 media [16].

Biological context of Methylmethacrylate

• Relative bioavailability was significantly increased with Eudragit nanoparticles compared to the nifedipine/PEG solution [17].
• In order to detect a possible hypomineralization in these vitamin D-deficient patients, we measured the bone mineral content in 64 transilial biopsies, embedded in methylmethacrylate for histomorphometric evaluation [18].
• After the addition of paracetamol the release characteristics were defined pointing out the great release control properties of both Eudragit L and RS, which showed different release kinetics depending on the pH of the environment [19].
• Two healthy breastfeeding women without exposure to methylmethacrylate served as controls [20].
• The AUC was threefold greater for HPMC (1067 +/- 437 nmole*h/ml) versus EUDRAGIT (320 +/- 51), and Cmax was nearly four times greater (145 +/- 62.1 nmole/ml for HPMC versus 37.9 +/- 14.4 for EUDRAGIT).(ABSTRACT TRUNCATED AT 250 WORDS)[21]

Anatomical context of Methylmethacrylate

• Previous studies have shown that momentary contact between a methylmethacrylate intraocular lens and the corneal endothelial cells results in extensive cell damage [22].
• A glued-on methylmethacrylate lens applied to corneas soon after burning, however, prevented re-epithelialization and also prevented PMN infiltration of the stroma and stromal ulceration [23].
• Cat corneal endothelium was damaged by a methylmethacrylate segment introduced into the anterior chamber [24].
• Methylmethacrylate lumenal castings of the ciliary body microvasculature were prepared from eight mammalian species and studied with the scanning electron microscope [25].
• This consisted of microgranules of indomethacin coated with an acrylic resin, Eudragit L, which releases drug in the small intestine [26].

Associations of Methylmethacrylate with other chemical compounds

• The maxilla was fixed in paraformaldehyde and embedded undecalcified in methylmethacrylate [27].
• Incorporation of the methacrylic acid polymer, Eudragit L100-55 resulted in marginal release enhancement as the pH modulation effected by this polymer was attenuated by the basicity of the drug [28].
• Molecular properties of ibuprofen and its solid dispersions with Eudragit RL100 studied by solid-state nuclear magnetic resonance [29].
• Preparation and evaluation of Eudragit gels. II: In vitro release of salicylic acid, sodium salicylate, and ketoprofen from Eudragit L and S organogels [30].
• Capsules containing 3 mg nicotine, combined with carbomer in Gelucire 50/13, were coated with an acrylic resin Eudragit L; this ensured the capsule would remain intact until the ileum [31].

Gene context of Methylmethacrylate

• Furthermore, cellular studies have shown that thrombin and certain cytotoxic chemicals, such as methylmethacrylate monomer (bone cement), separately and together trigger monocytes to tissue factor (TF) expression and cause endothelial cell shape changes and detachment [32].
• Size-exclusion chromatography (SEC) combined with online multi-angle light scattering (MALS) and refractometric (RI) detection has been employed for the molar mass characterisation of water-insoluble cationic methyl methacrylate-ethyl acrylate copolymers (Eudragit RS and RL) [33].
• Following, bone specimen were embedded in methylmethacrylate and analyzed by spectral image acquisition using a Sagnac type interferometer (ASI, Israel) [34].
• The surface layer is made of an enteric pH-sensitive polymer such as hydroxypropylmethylcellulose phthalate (HP-55), Eudragit L100 or S100 and was coated with an adhesive layer [35].
• Considering the high biological safety of Eudragit RS and PEG 400, the EPG membranes might be used to develop a novel thermo-sensitive drug delivery system [36].

Analytical, diagnostic and therapeutic context of Methylmethacrylate

• Either surface debridement or glued-on methylmethacrylate rings also prevented re-epithelialization and ulceration in stromas not infiltrated by PMNs, but neither treatment was sufficient to prevent ulceration in corneas already containing numerous PMNs [23].
• Lethal progression of heart block after prosthesis cementing with methylmethacrylate [37].
• Intravesical methylmethacrylate after revision hip arthroplasty [38].
• A pH-sensitive polymer Eudragit P-4135F was used to prepare microspheres by a simple oil/water emulsification process [39].
• Intravenous methylmethacrylate after total hip replacement [40].

References