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Chemical Compound Review

Metaplex     methyl 2-methylprop-2-enoate

Synonyms: Kallocryl, Plexiglas, Sintex, Cranioplast, Kallocryl A, ...
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Disease relevance of Methylmethacrylate


Psychiatry related information on Methylmethacrylate

  • In week 17 oral therapy started: Gr.3 and 6: 60mg Eudragit/kg body weight/d (vehicle of MMPI), Gr.7 and 8: 40mg, respectively, 120mg RO 28-2653/kg body weight/d; Gr.1, 2, 4, 5: no therapy [6].

High impact information on Methylmethacrylate

  • Mesalamine microgranular preparation was a gelatin capsule containing 400 mg of mesalamine microgranules coated with Eudragit S, which has been shown to deliver the drug in the terminal ileum [7].
  • Reduction in myocardial temperature and heart rate by means of reduction in perfusate temperature of the isolated hearts reduced the myocardial depressant effect of methylmethacrylate [8].
  • The optic nerve and peripapillary choroidal vessels were sequentially microdissected, using methylmethacrylate corrosion microvascular castings, and were examined with a scanning electron microscope to determine the three-dimensional relationships of the vessels [9].
  • Intraocular connections of these vessels were then documented with scanning electron microscopy of methylmethacrylate microvascular luminal castings [10].
  • The antibody powders were obtained by spray drying the water-soluble protein fraction of egg yolks from immunized hens after the lipid components were precipitated with an aqueous dispersion of acrylic resins (Eudragit L30D-55; Rohm pharma) [11].

Chemical compound and disease context of Methylmethacrylate


Biological context of Methylmethacrylate

  • Relative bioavailability was significantly increased with Eudragit nanoparticles compared to the nifedipine/PEG solution [17].
  • In order to detect a possible hypomineralization in these vitamin D-deficient patients, we measured the bone mineral content in 64 transilial biopsies, embedded in methylmethacrylate for histomorphometric evaluation [18].
  • After the addition of paracetamol the release characteristics were defined pointing out the great release control properties of both Eudragit L and RS, which showed different release kinetics depending on the pH of the environment [19].
  • Two healthy breastfeeding women without exposure to methylmethacrylate served as controls [20].
  • The AUC was threefold greater for HPMC (1067 +/- 437 nmole*h/ml) versus EUDRAGIT (320 +/- 51), and Cmax was nearly four times greater (145 +/- 62.1 nmole/ml for HPMC versus 37.9 +/- 14.4 for EUDRAGIT).(ABSTRACT TRUNCATED AT 250 WORDS)[21]

Anatomical context of Methylmethacrylate


Associations of Methylmethacrylate with other chemical compounds


Gene context of Methylmethacrylate

  • Furthermore, cellular studies have shown that thrombin and certain cytotoxic chemicals, such as methylmethacrylate monomer (bone cement), separately and together trigger monocytes to tissue factor (TF) expression and cause endothelial cell shape changes and detachment [32].
  • Size-exclusion chromatography (SEC) combined with online multi-angle light scattering (MALS) and refractometric (RI) detection has been employed for the molar mass characterisation of water-insoluble cationic methyl methacrylate-ethyl acrylate copolymers (Eudragit RS and RL) [33].
  • Following, bone specimen were embedded in methylmethacrylate and analyzed by spectral image acquisition using a Sagnac type interferometer (ASI, Israel) [34].
  • The surface layer is made of an enteric pH-sensitive polymer such as hydroxypropylmethylcellulose phthalate (HP-55), Eudragit L100 or S100 and was coated with an adhesive layer [35].
  • Considering the high biological safety of Eudragit RS and PEG 400, the EPG membranes might be used to develop a novel thermo-sensitive drug delivery system [36].

Analytical, diagnostic and therapeutic context of Methylmethacrylate


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  9. Optic nerve and peripapillary choroidal microvasculature of the rat eye. Sugiyama, K., Gu, Z.B., Kawase, C., Yamamoto, T., Kitazawa, Y. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
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  11. Passive protective effect of chicken egg yolk immunoglobulins against experimental enterotoxigenic Escherichia coli infection in neonatal piglets. Yokoyama, H., Peralta, R.C., Diaz, R., Sendo, S., Ikemori, Y., Kodama, Y. Infect. Immun. (1992) [Pubmed]
  12. Novel biocompatible anionic polymeric microspheres for the delivery of the HIV-1 Tat protein for vaccine application. Caputo, A., Brocca-Cofano, E., Castaldello, A., De Michele, R., Altavilla, G., Marchisio, M., Gavioli, R., Rolen, U., Chiarantini, L., Cerasi, A., Dominici, S., Magnani, M., Cafaro, A., Sparnacci, K., Laus, M., Tondelli, L., Ensoli, B. Vaccine (2004) [Pubmed]
  13. Mutagenicity of dentin bonding agents. Schweikl, H., Schmalz, G., Bey, B. J. Biomed. Mater. Res. (1994) [Pubmed]
  14. Organic esters of plasticizers affecting the water absorption, adhesive property, glass transition temperature and plasticizer permanence of eudragit acrylic films. Lin, S.Y., Chen, K.S., Run-Chu, L. Journal of controlled release : official journal of the Controlled Release Society. (2000) [Pubmed]
  15. Therapeutic percutaneous injections in the treatment of malignant acetabular osteolyses. Cotten, A., Demondion, X., Boutry, N., Cortet, B., Chastanet, P., Duquesnoy, B., Leblond, D. Radiographics : a review publication of the Radiological Society of North America, Inc. (1999) [Pubmed]
  16. Physicochemical properties of enteric films prepared from aqueous dispersions and organic solutions. Bando, H., McGinity, J.W. International journal of pharmaceutics. (2006) [Pubmed]
  17. The antihypertensive effect of orally administered nifedipine-loaded nanoparticles in spontaneously hypertensive rats. Kim, Y.I., Fluckiger, L., Hoffman, M., Lartaud-Idjouadiene, I., Atkinson, J., Maincent, P. Br. J. Pharmacol. (1997) [Pubmed]
  18. Bone mineral content of transilial biopsies in patients with hip fracture. Hogervorst, E.J., Lips, P., de Blieck-Hogervorst, J.M., van der Vijgh, W.J., Netelenbos, J.C. Bone (1985) [Pubmed]
  19. Acrylic polymers as thickening agents for tetraglycol cosolvent. Bonacucina, G., Palmieri, G.F. Journal of pharmaceutical sciences. (2006) [Pubmed]
  20. Serum and breast milk levels of methylmethacrylate following surgeon exposure during arthroplasty. Linehan, C.M., Gioe, T.J. The Journal of bone and joint surgery. American volume. (2006) [Pubmed]
  21. Use of stable isotopes for evaluation of drug delivery systems: comparison of ibuprofen release in vivo and in vitro from two biphasic release formulations utilizing different rate-controlling polymers. Theis, D.L., Lucisano, L.J., Halstead, G.W. Pharm. Res. (1994) [Pubmed]
  22. Minimizing corneal endothelial damage due to intraocular lens contact. Kirk, S., Burde, R.M., Waltman, S.R. Invest. Ophthalmol. Vis. Sci. (1977) [Pubmed]
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  25. Comparative microvascular anatomy of mammalian ciliary processes. Morrison, J.C., DeFrank, M.P., Van Buskirk, E.M. Invest. Ophthalmol. Vis. Sci. (1987) [Pubmed]
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  27. Histomorphometric study of bone reactions during orthodontic tooth movement in rats. Verna, C., Zaffe, D., Siciliani, G. Bone (1999) [Pubmed]
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  29. Molecular properties of ibuprofen and its solid dispersions with Eudragit RL100 studied by solid-state nuclear magnetic resonance. Geppi, M., Guccione, S., Mollica, G., Pignatello, R., Veracini, C.A. Pharm. Res. (2005) [Pubmed]
  30. Preparation and evaluation of Eudragit gels. II: In vitro release of salicylic acid, sodium salicylate, and ketoprofen from Eudragit L and S organogels. Kawata, M., Suzuki, T., Kim, N.S., Ito, T., Kurita, A., Miyagoe, Y., Goto, S. Journal of pharmaceutical sciences. (1991) [Pubmed]
  31. An oral formulation of nicotine for release and absorption in the colon: its development and pharmacokinetics. Green, J.T., Evans, B.K., Rhodes, J., Thomas, G.A., Ranshaw, C., Feyerabend, C., Russell, M.A. British journal of clinical pharmacology. (1999) [Pubmed]
  32. The role of the pulmonary circulation in the regulation of coagulation and fibrinolysis in relation to major surgery. Dahl, O.E. J. Cardiothorac. Vasc. Anesth. (1997) [Pubmed]
  33. Molar mass characterization of cationic methyl methacrylate-ethyl acrylate copolymers using size-exclusion chromatography with online multi-angle light scattering and refractometric detection. Wittgren, B., Welinder, A., Porsch, B. Journal of chromatography. A. (2003) [Pubmed]
  34. Polychrome labeling of bone with seven different fluorochromes: enhancing fluorochrome discrimination by spectral image analysis. Pautke, C., Vogt, S., Tischer, T., Wexel, G., Deppe, H., Milz, S., Schieker, M., Kolk, A. Bone (2005) [Pubmed]
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  36. Application of Eudragit RS to thermo-sensitive drug delivery systems: II. Effect of temperature on drug permeability through membrane consisting of Eudragit RS/PEG 400 blend polymers. Fujimori, J., Yoshihashi, Y., Yonemochi, E., Terada, K. Journal of controlled release : official journal of the Controlled Release Society. (2005) [Pubmed]
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