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Gene Review:

oxyS - ncRNA

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3952, JWR0098

Lee, Y.Y. et al., Rosen, H. et al., Ma, W. et al., Cui, Y. et al., Johnson, J.R. et al., et al.

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Disease relevance of oxyS

The oxyR and oxyS genes of wild-type E. coli strain Ec1a (O1:K1:H7) were replaced with a kanamycin resistance cassette to produce an oxyRS mutant [1].
Molecular characterization of global regulatory RNA species that control pathogenicity factors in Erwinia amylovora and Erwinia herbicola pv. gypsophilae [2].

High impact information on oxyS

In vitro transcription assays demonstrated that avicins activate OxyR and its target genes katG and oxyS in a DTT-reversible manner [3].
ExpR, a LuxR homolog of Erwinia carotovora subsp. carotovora, activates transcription of rsmA, which specifies a global regulatory RNA-binding protein [4].
Probably the BtuB is negatively regulated by a global regulator, oxyS, induced during oxidative stress [5].
Our RT-PCR analysis revealed an elevation of expression of the oxyS gene in the lon mutant [5].
Comparisons were made both by traditional and QPCR methods with similar results and indicate that the survival defect of an oxyR and oxyS mutant described previously can be attributed to the loss of oxyR alone [6].

References

Effect of inactivation of the global oxidative stress regulator oxyR on the colonization ability of Escherichia coli O1:K1:H7 in a mouse model of ascending urinary tract infection. Johnson, J.R., Clabots, C., Rosen, H. Infect. Immun. (2006) [Pubmed]
Molecular characterization of global regulatory RNA species that control pathogenicity factors in Erwinia amylovora and Erwinia herbicola pv. gypsophilae. Ma, W., Cui, Y., Liu, Y., Dumenyo, C.K., Mukherjee, A., Chatterjee, A.K. J. Bacteriol. (2001) [Pubmed]
Avicinylation (thioesterification): a protein modification that can regulate the response to oxidative and nitrosative stress. Haridas, V., Kim, S.O., Nishimura, G., Hausladen, A., Stamler, J.S., Gutterman, J.U. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
ExpR, a LuxR homolog of Erwinia carotovora subsp. carotovora, activates transcription of rsmA, which specifies a global regulatory RNA-binding protein. Cui, Y., Chatterjee, A., Hasegawa, H., Dixit, V., Leigh, N., Chatterjee, A.K. J. Bacteriol. (2005) [Pubmed]
An E. coli lon mutant conferring partial resistance to colicin may reveal a novel role in regulating proteins involved in the translocation of colicin. Lee, Y.Y., Hu, H.T., Liang, P.H., Chak, K.F. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
Neutrophil microbicidal activity: screening bacterial mutants for survival after phagocytosis using quantitative PCR. Rosen, H., Lewis, P.J., Nitzel, C.M. Jpn. J. Infect. Dis. (2004) [Pubmed]

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