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Chemical Compound Review

kanamycin     (2R,3S,4S,5R,6R)-2- (aminomethyl)-6-[(1R,2R...

Synonyms: Klebcil, Kanamicina, Kanamycine, Kanamycinum, KANAMYCIN A, ...
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Disease relevance of KANAMYCIN A


Psychiatry related information on KANAMYCIN A


High impact information on KANAMYCIN A


Chemical compound and disease context of KANAMYCIN A


Biological context of KANAMYCIN A

  • These results suggest that (a) high-level resistance to streptomycin and kanamycin among some clinical isolates of enterococci is associated with a 45 megadalton plasmid, and (b) the same plasmid is also responsible for the resistance to penicillin-aminoglycoside synergism observed in these strains [21].
  • Cartridge mutagenesis techniques were used to generate a deletion mutant of Synechocystis 6803 in which the psbE and psbF genes were replaced by a kanamycin-resistance gene cartridge [22].
  • Due to the original linkage of the oncogene with the cosmid containing the kanamycin resistance gene, a series of kanamycin-resistant cosmids were isolated, five of which contained an active oncogene [23].
  • The unit was composed of short direct repeats (9, 18 or 27 bp) which flanked inverted repeats (0, 8 or 308 bp) and a gene encoding kanamycin resistance [24].
  • The functional oncogene was cloned by preparing cosmid libraries of third round tumour DNAs, using a cosmid which does not contain a kanamycin resistance gene [23].

Anatomical context of KANAMYCIN A

  • A high voltage electrical pulse was applied to the protoplasts, which were then grown on filters placed over feeder layers of maize suspension cells (Black Mexican Sweet) and selected for growth in the presence of kanamycin [25].
  • Oral administration of antibiotics (kanamycin and/or metronidazole for 2 days) significantly reduced constitutive ICAM-1 expression in the cecum, but not in the distal colon [26].
  • It induced kanamycin resistance in E. coli, as well as resistance to the drug G418 in rat and mouse fibroblasts [27].
  • This vector contains the complete bovine papilloma virus genome, a ColE1 replication origin and a dominant selectable marker conferring resistance to kanamycin in bacteria and G418 in eukaryotic cells [28].
  • Here we describe the generation of marker-free chloroplast transformants in tobacco using the reconstitution of wild-type pigmentation in combination with plastid transformation vectors, which prevent stable integration of the kanamycin selection marker [29].

Associations of KANAMYCIN A with other chemical compounds


Gene context of KANAMYCIN A

  • To study the function of the CtpA protein, we inactivated the ctpA gene by inserting a kanamycin-resistance gene into its coding sequence [35].
  • This gene, termed zntA, was disrupted by insertion of a kanamycin gene through homologous recombination [36].
  • The copA gene was disrupted by insertion of a kanamycin gene through homologous recombination [37].
  • Caspase-independent pathways of hair cell death induced by kanamycin in vivo [38].
  • Insertion of a kanamycin resistance gene in the omega gene reduces spoT gene expression as judged by lowered ppGppase activity, relA-dependent reduction of growth rate, and abolition of spoT mutant complementation activity [39].

Analytical, diagnostic and therapeutic context of KANAMYCIN A

  • When introduced into M. smegmatis or BCG (Mycobacterium tuberculosis typus bovinus var. Bacille-Calmette-Guérin) by electroporation, these shuttle plasmids conferred stable kanamycin resistance upon transformants [40].
  • The development of infection over 6 h and its regression after kanamycin treatment were visualized by whole-body imaging [41].
  • The resulting kanamycin resistant clones were screened for possible recombination products by PCR, which proved to be a valuable technique for this analysis [42].
  • Seventeen patients had intraoperative peritoneal lavage with a solution containing one gram of kanamycin in 200 ml of 0.9% NaCl [43].
  • Kanamycin lavage for wound prophylaxis should be used cautiously and should be abandoned in patients who have renal impairment where prolonged toxic serum concentrations could develop [43].


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  18. Mutation of the htrB locus of Haemophilus influenzae nontypable strain 2019 is associated with modifications of lipid A and phosphorylation of the lipo-oligosaccharide. Lee, N.G., Sunshine, M.G., Engstrom, J.J., Gibson, B.W., Apicella, M.A. J. Biol. Chem. (1995) [Pubmed]
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