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Gene Review:

GPR27 - G protein-coupled receptor 27

Homo sapiens

Synonyms: SREB1, Super conserved receptor expressed in brain 1

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High impact information on GPR27

Transcripts corresponding to GPR27 and GPR30 were detected in several areas of human and rat CNS, While GPR35 expression was detected only in the rat intestine [1].
Further, the anatomical expression of SREB1 and SREB3 overlapped with that of SREB2 in the adult monkey brain [2].
Radiation hybrid analysis localized SREB1, SREB2, and SREB3 genes to different human chromosomes, namely 3p21-p14, 7q31 and Xp11, respectively [3].

References

Discovery of three novel G-protein-coupled receptor genes. O'Dowd, B.F., Nguyen, T., Marchese, A., Cheng, R., Lynch, K.R., Heng, H.H., Kolakowski, L.F., George, S.R. Genomics (1998) [Pubmed]
A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain. Matsumoto, M., Beltaifa, S., Weickert, C.S., Herman, M.M., Hyde, T.M., Saunders, R.C., Lipska, B.K., Weinberger, D.R., Kleinman, J.E. Brain Res. Mol. Brain Res. (2005) [Pubmed]
An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. Matsumoto, M., Saito, T., Takasaki, J., Kamohara, M., Sugimoto, T., Kobayashi, M., Tadokoro, M., Matsumoto, S., Ohishi, T., Furuichi, K. Biochem. Biophys. Res. Commun. (2000) [Pubmed]

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LOC720525	Macaca mulatta
Gpr27	Mus musculus
GPR27	Pan troglodytes
Gpr27	Rattus norvegicus

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