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Gene Review

GPR35  -  G protein-coupled receptor 35

Homo sapiens

Synonyms: G-protein coupled receptor 35, KYNA receptor, Kynurenic acid receptor
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Disease relevance of GPR35


High impact information on GPR35


Biological context of GPR35


Associations of GPR35 with chemical compounds


Other interactions of GPR35

  • Transcripts corresponding to GPR27 and GPR30 were detected in several areas of human and rat CNS, While GPR35 expression was detected only in the rat intestine [4].
  • We also believe that the deletion of GPR35 could be responsible for the entity brachydactyly mental retardation syndrome (OMIM #600430), which was coined based on the above minority of patients with terminal 2q37 deletion [5].


  1. Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. Wang, J., Simonavicius, N., Wu, X., Swaminath, G., Reagan, J., Tian, H., Ling, L. J. Biol. Chem. (2006) [Pubmed]
  2. Cloning of a G-protein-coupled receptor that shows an activity to transform NIH3T3 cells and is expressed in gastric cancer cells. Okumura, S., Baba, H., Kumada, T., Nanmoku, K., Nakajima, H., Nakane, Y., Hioki, K., Ikenaka, K. Cancer Sci. (2004) [Pubmed]
  3. Population genetics of CAPN10 and GPR35: implications for the evolution of type 2 diabetes variants. Vander Molen, J., Frisse, L.M., Fullerton, S.M., Qian, Y., Del Bosque-Plata, L., Hudson, R.R., Di Rienzo, A. Am. J. Hum. Genet. (2005) [Pubmed]
  4. Discovery of three novel G-protein-coupled receptor genes. O'Dowd, B.F., Nguyen, T., Marchese, A., Cheng, R., Lynch, K.R., Heng, H.H., Kolakowski, L.F., George, S.R. Genomics (1998) [Pubmed]
  5. Molecular delineation of deletions on 2q37.3 in three cases with an Albright hereditary osteodystrophy-like phenotype. Shrimpton, A.E., Braddock, B.R., Thomson, L.L., Stein, C.K., Hoo, J.J. Clin. Genet. (2004) [Pubmed]
  6. Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35. Taniguchi, Y., Tonai-Kachi, H., Shinjo, K. FEBS Lett. (2006) [Pubmed]
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