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Gene Review

GPR85  -  G protein-coupled receptor 85

Homo sapiens

Synonyms: SREB, SREB2, Super conserved receptor expressed in brain 2
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High impact information on GPR85

  • A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain [1].
  • As a first step in understanding the function of the SREB family, we have determined the anatomical gene expression profile of SREB2 in adult human, monkey, and rat forebrain using in situ hybridization histochemistry [1].
  • The areas expressing high levels of SREB2 mRNA overlap with brain structures known to possess high levels of plasticity, namely, the hippocampal formation, olfactory system, and supraoptic and paraventricular nuclei [1].
  • SREB2 mRNA was expressed in neurons throughout the brain and the most abundant expression was detected in the hippocampal dentate gyrus in all species examined [1].
  • Amino acid sequence identity between human and rat orthologues is 97% for SREB1 and 99% for SREB3, while the SREB2 sequence is surprisingly completely identical between the species [2].

Biological context of GPR85


Anatomical context of GPR85


Associations of GPR85 with chemical compounds

  • A factor analysis of the SREB (Southern Regional Education Board) Attendant Opinion Scale was performed, based on the responses of 105 subjects [4].


  1. A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain. Matsumoto, M., Beltaifa, S., Weickert, C.S., Herman, M.M., Hyde, T.M., Saunders, R.C., Lipska, B.K., Weinberger, D.R., Kleinman, J.E. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  2. An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. Matsumoto, M., Saito, T., Takasaki, J., Kamohara, M., Sugimoto, T., Kobayashi, M., Tadokoro, M., Matsumoto, S., Ohishi, T., Furuichi, K. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  3. School nursing role and competence. Poster, E.C., Marcontel, M. The Journal of school nursing : the official publication of the National Association of School Nurses. (1999) [Pubmed]
  4. Factor structure of the SREB Attendant Opinion Scale. Silverstein, A.B., McLain, R.E., Brownlee, L., Hubbell, M. American journal of mental deficiency. (1976) [Pubmed]
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