High impact information on GPR85

• A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain [1].
• As a first step in understanding the function of the SREB family, we have determined the anatomical gene expression profile of SREB2 in adult human, monkey, and rat forebrain using in situ hybridization histochemistry [1].
• The areas expressing high levels of SREB2 mRNA overlap with brain structures known to possess high levels of plasticity, namely, the hippocampal formation, olfactory system, and supraoptic and paraventricular nuclei [1].
• SREB2 mRNA was expressed in neurons throughout the brain and the most abundant expression was detected in the hippocampal dentate gyrus in all species examined [1].
• Amino acid sequence identity between human and rat orthologues is 97% for SREB1 and 99% for SREB3, while the SREB2 sequence is surprisingly completely identical between the species [2].

Biological context of GPR85

• Furthermore, amino acid sequence of zebrafish SREB2 and SREB3 are 94 and 78% identical to mammal orthologues [2].
• Radiation hybrid analysis localized SREB1, SREB2, and SREB3 genes to different human chromosomes, namely 3p21-p14, 7q31 and Xp11, respectively [2].
• The Southern Regional Education Board/Council on Collegiate Education for Nursing (SREB/CCEN) is exploring a linkage of undergraduate nursing curriculum to school nursing competencies [3].

Anatomical context of GPR85

• Northern blot analysis revealed that SREB members are predominantly expressed in the brain regions and genital organs [2].
• The high sequence conservation and abundant expression in the central nervous system suggest the existence of undiscovered fundamental neuronal systems consisting of SREB family members and their endogenous ligand(s) [2].

Associations of GPR85 with chemical compounds

• A factor analysis of the SREB (Southern Regional Education Board) Attendant Opinion Scale was performed, based on the responses of 105 subjects [4].

References