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Gene Review:

IGHD3-3 - immunoglobulin heavy diversity 3-3

Homo sapiens

Synonyms: DXP4, IGHD33

Widhopf, G.F. et al., Efremov, D.G. et al., Stamatopoulos, K. et al., Mariette, X. et al.

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High impact information on IGHD3-3

A strikingly similar H-chain CDR3 region that contained a single reading frame of the DXP4 DH gene segment, and N-encoded proline at the DH/JH boundary, and a tyrosine-rich region encoded by the JH6 gene segment was observed in four CLL-AIHA cases [1].
The rearranged 51p1 genes expressed by CLL B cells have a distinctive use of D segments D3-3/DXP4 and D3-10/DXP'1, a favored use of J(H)6, and a longer third complementarity-determining region than the rearranged Ig genes used by CLL B cells that express V(H)1 genes other than V(H)1-69 [2].
A computer-based search in previously published and/or submitted to GenBank bcl-1/JH junctional sequences identified homology to D genes in 1/4 MCL tumour samples and 1/4 MCl cell lines; DXP4 or D23/7 and DHQ52 or D22/21 or DXP5, respectively [3].
Nucleotide sequence analysis of the variable domain of the mu chain indicated the utilization of the VH4 71.2 gene or one allotypic variant, DXP4 and JH3 segments [4].

References

Restricted immunoglobulin VH region repertoire in chronic lymphocytic leukemia patients with autoimmune hemolytic anemia. Efremov, D.G., Ivanovski, M., Siljanovski, N., Pozzato, G., Cevreska, L., Fais, F., Chiorazzi, N., Batista, F.D., Burrone, O.R. Blood (1996) [Pubmed]
Normal B cells express 51p1-encoded Ig heavy chains that are distinct from those expressed by chronic lymphocytic leukemia B cells. Widhopf, G.F., Kipps, T.J. J. Immunol. (2001) [Pubmed]
Molecular analysis of bcl-1/IgH junctional sequences in mantle cell lymphoma: potential mechanism of the t(11;14) chromosomal translocation. Stamatopoulos, K., Kosmas, C., Belessi, C., Kyriazopoulos, P., Papadaki, T., Anagnostou, D., Loukopoulos, D. Br. J. Haematol. (1999) [Pubmed]
Characterization of a human monoclonal autoantibody directed to cardiolipin/beta 2 glycoprotein I produced by chronic lymphocytic leukaemia B cells. Mariette, X., Levy, Y., Dubreuil, M.L., Intrator, L., Danon, F., Brouet, J.C. Clin. Exp. Immunol. (1993) [Pubmed]

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