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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Genes, Immunoglobulin

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Analytical, diagnostic and therapeutic context of Genes, Immunoglobulin

  • For all the mu kappa-producing XLA B cell lines, the mu and kappa mRNA transcripts were of native size, and sequence analysis across the regions of VHDJH and V kappa J kappa gene joining showed that Ig gene rearrangements occurred in a typical manner [34].
  • However, clinical trials are required to determine whether poor-prognosis leukemia-cell markers, such as expression of unmutated immunoglobulin genes or the zeta-associated protein of 70 kDa (ZAP-70), can be used as the basis for determining the time or type of therapy [35].
  • Tumor contamination in the autografts was assessed by a quantitative polymerase chain reaction detection assay using patient-specific, complementarity-determining region (CDR) Ig gene primers before and after CD34 selection [36].
  • Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor [37].
  • PCR analysis of immunoglobulin gene rearrangements demonstrated that four of the five biopsies (80%) gave rise to scid tumours which represented the original tumour cell clones [38].


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  2. Individual tumors of multifocal EB virus-induced malignant lymphomas in tamarins arise from different B-cell clones. Cleary, M.L., Epstein, M.A., Finerty, S., Dorfman, R.F., Bornkamm, G.W., Kirkwood, J.K., Morgan, A.J., Sklar, J. Science (1985) [Pubmed]
  3. Diversification, not use, of the immunoglobulin VH gene repertoire is restricted in DiGeorge syndrome. Haire, R.N., Buell, R.D., Litman, R.T., Ohta, Y., Fu, S.M., Honjo, T., Matsuda, F., de la Morena, M., Carro, J., Good, R.A. J. Exp. Med. (1993) [Pubmed]
  4. Restricted use of fetal VH3 immunoglobulin genes by unselected B cells in the adult. Predominance of 56p1-like VH genes in common variable immunodeficiency. Braun, J., Berberian, L., King, L., Sanz, I., Govan, H.L. J. Clin. Invest. (1992) [Pubmed]
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  6. Death by deamination: a novel host restriction system for HIV-1. Goff, S.P. Cell (2003) [Pubmed]
  7. E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Bain, G., Maandag, E.C., Izon, D.J., Amsen, D., Kruisbeek, A.M., Weintraub, B.C., Krop, I., Schlissel, M.S., Feeney, A.J., van Roon, M. Cell (1994) [Pubmed]
  8. Selective expression of RAG-2 in chicken B cells undergoing immunoglobulin gene conversion. Carlson, L.M., Oettinger, M.A., Schatz, D.G., Masteller, E.L., Hurley, E.A., McCormack, W.T., Baltimore, D., Thompson, C.B. Cell (1991) [Pubmed]
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  10. Lymphoid blast crises of chronic myelogenous leukemia represent stages in the development of B-cell precursors. Bakhshi, A., Minowada, J., Arnold, A., Cossman, J., Jensen, J.P., Whang-Peng, J., Waldmann, T.A., Korsmeyer, S.J. N. Engl. J. Med. (1983) [Pubmed]
  11. Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in mice. Greenough, T.C., Babcock, G.J., Roberts, A., Hernandez, H.J., Thomas, W.D., Coccia, J.A., Graziano, R.F., Srinivasan, M., Lowy, I., Finberg, R.W., Subbarao, K., Vogel, L., Somasundaran, M., Luzuriaga, K., Sullivan, J.L., Ambrosino, D.M. J. Infect. Dis. (2005) [Pubmed]
  12. Somatic hypermutation and diverse immunoglobulin gene usage in the human antibody response to the capsular polysaccharide of Streptococcus pneumoniae Type 6B. Zhou, J., Lottenbach, K.R., Barenkamp, S.J., Reason, D.C. Infect. Immun. (2004) [Pubmed]
  13. Detection of immunoglobulin gene rearrangement of B cell non-Hodgkin's lymphomas and leukemias in fresh, unfixed and formalin-fixed, paraffin-embedded tissue by polymerase chain reaction. Inghirami, G., Szabolcs, M.J., Yee, H.T., Corradini, P., Cesarman, E., Knowles, D.M. Lab. Invest. (1993) [Pubmed]
  14. Transcription enhancer identified near the human C mu immunoglobulin heavy chain gene is unavailable to the translocated c-myc gene in a Burkitt lymphoma. Rabbitts, T.H., Forster, A., Baer, R., Hamlyn, P.H. Nature (1983) [Pubmed]
  15. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Hartley, S.B., Crosbie, J., Brink, R., Kantor, A.B., Basten, A., Goodnow, C.C. Nature (1991) [Pubmed]
  16. Growth cone guidance in insects: fasciclin II is a member of the immunoglobulin superfamily. Harrelson, A.L., Goodman, C.S. Science (1988) [Pubmed]
  17. Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival. Corcoran, L.M., Karvelas, M., Nossal, G.J., Ye, Z.S., Jacks, T., Baltimore, D. Genes Dev. (1993) [Pubmed]
  18. TCT.1, a target molecule for gamma/delta T cells, is encoded by an immunoglobulin superfamily gene (Blast-1) located in the CD1 region of human chromosome 1. Del Porto, P., Mami-Chouaib, F., Bruneau, J.M., Jitsukawa, S., Dumas, J., Harnois, M., Hercend, T. J. Exp. Med. (1991) [Pubmed]
  19. A novel receptor involved in T-cell activation. Cocks, B.G., Chang, C.C., Carballido, J.M., Yssel, H., de Vries, J.E., Aversa, G. Nature (1995) [Pubmed]
  20. V(D)J recombinase activity in a subset of germinal center B lymphocytes. Han, S., Dillon, S.R., Zheng, B., Shimoda, M., Schlissel, M.S., Kelsoe, G. Science (1997) [Pubmed]
  21. The half-life of immunoglobulin mRNA increases during B-cell differentiation: a possible role for targeting to membrane-bound polysomes. Mason, J.O., Williams, G.T., Neuberger, M.S. Genes Dev. (1988) [Pubmed]
  22. Functional analysis of the human vascular cell adhesion molecule 1 promoter. Neish, A.S., Williams, A.J., Palmer, H.J., Whitley, M.Z., Collins, T. J. Exp. Med. (1992) [Pubmed]
  23. Induction of immunoglobulin gene expression in mouse fibroblasts by cycloheximide treatment. Ishihara, T., Kudo, A., Watanabe, T. J. Exp. Med. (1984) [Pubmed]
  24. Oct-2 is required early in T cell-independent B cell activation for G1 progression and for proliferation. Corcoran, L.M., Karvelas, M. Immunity (1994) [Pubmed]
  25. MSH2-MSH6 stimulates DNA polymerase eta, suggesting a role for A:T mutations in antibody genes. Wilson, T.M., Vaisman, A., Martomo, S.A., Sullivan, P., Lan, L., Hanaoka, F., Yasui, A., Woodgate, R., Gearhart, P.J. J. Exp. Med. (2005) [Pubmed]
  26. Development of B-1 cells: segregation of phosphatidyl choline-specific B cells to the B-1 population occurs after immunoglobulin gene expression. Arnold, L.W., Pennell, C.A., McCray, S.K., Clarke, S.H. J. Exp. Med. (1994) [Pubmed]
  27. Rearrangement between ornithine decarboxylase and the switch region of the gamma 1 immunoglobulin gene in alpha-difluoromethylornithine resistant mouse myeloma cells. Katz, A., Kahana, C. EMBO J. (1989) [Pubmed]
  28. Determinants of the phagocytic signal mediated by the type IIIA Fc gamma receptor, Fc gamma RIIIA: sequence requirements and interaction with protein-tyrosine kinases. Park, J.G., Schreiber, A.D. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  29. Failure of B-cell differentiation in mice lacking the transcription factor EBF. Lin, H., Grosschedl, R. Nature (1995) [Pubmed]
  30. Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Grawunder, U., Wilm, M., Wu, X., Kulesza, P., Wilson, T.E., Mann, M., Lieber, M.R. Nature (1997) [Pubmed]
  31. MRE11/RAD50 cleaves DNA in the AID/UNG-dependent pathway of immunoglobulin gene diversification. Larson, E.D., Cummings, W.J., Bednarski, D.W., Maizels, N. Mol. Cell (2005) [Pubmed]
  32. Immunoglobulin recombinase gene activity is modulated reciprocally by interleukin 7 and CD19 in B cell progenitors. Billips, L.G., Nuñez, C.A., Bertrand, F.E., Stankovic, A.K., Gartland, G.L., Burrows, P.D., Cooper, M.D. J. Exp. Med. (1995) [Pubmed]
  33. Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line. Simpson, L.J., Sale, J.E. EMBO J. (2003) [Pubmed]
  34. Clonal diversity in the B cell repertoire of patients with X-linked agammaglobulinemia. Anker, R., Conley, M.E., Pollok, B.A. J. Exp. Med. (1989) [Pubmed]
  35. Perspectives on the use of new diagnostic tools in the treatment of chronic lymphocytic leukemia. Binet, J.L., Caligaris-Cappio, F., Catovsky, D., Cheson, B., Davis, T., Dighiero, G., Döhner, H., Hallek, M., Hillmen, P., Keating, M., Montserrat, E., Kipps, T.J., Rai, K. Blood (2006) [Pubmed]
  36. Multicenter phase III trial to evaluate CD34(+) selected versus unselected autologous peripheral blood progenitor cell transplantation in multiple myeloma. Vescio, R., Schiller, G., Stewart, A.K., Ballester, O., Noga, S., Rugo, H., Freytes, C., Stadtmauer, E., Tarantolo, S., Sahebi, F., Stiff, P., Meharchard, J., Schlossman, R., Brown, R., Tully, H., Benyunes, M., Jacobs, C., Berenson, R., DiPersio, J., Anderson, K., Berenson, J. Blood (1999) [Pubmed]
  37. Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor. Jackson, D.G., Hart, D.N., Starling, G., Bell, J.I. Eur. J. Immunol. (1992) [Pubmed]
  38. Expansion in scid mice of Epstein-Barr virus-associated post-transplantation lymphoproliferative disease biopsy material. Johannessen, I., Perera, S.M., Gallagher, A., Hopwood, P.A., Thomas, J.A., Crawford, D.H. J. Gen. Virol. (2002) [Pubmed]
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