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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Genes, Immunoglobulin

 
 
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Disease relevance of Genes, Immunoglobulin

 

High impact information on Genes, Immunoglobulin

 

Chemical compound and disease context of Genes, Immunoglobulin

 

Biological context of Genes, Immunoglobulin

 

Anatomical context of Genes, Immunoglobulin

 

Associations of Genes, Immunoglobulin with chemical compounds

 

Gene context of Genes, Immunoglobulin

 

Analytical, diagnostic and therapeutic context of Genes, Immunoglobulin

  • For all the mu kappa-producing XLA B cell lines, the mu and kappa mRNA transcripts were of native size, and sequence analysis across the regions of VHDJH and V kappa J kappa gene joining showed that Ig gene rearrangements occurred in a typical manner [34].
  • However, clinical trials are required to determine whether poor-prognosis leukemia-cell markers, such as expression of unmutated immunoglobulin genes or the zeta-associated protein of 70 kDa (ZAP-70), can be used as the basis for determining the time or type of therapy [35].
  • Tumor contamination in the autografts was assessed by a quantitative polymerase chain reaction detection assay using patient-specific, complementarity-determining region (CDR) Ig gene primers before and after CD34 selection [36].
  • Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor [37].
  • PCR analysis of immunoglobulin gene rearrangements demonstrated that four of the five biopsies (80%) gave rise to scid tumours which represented the original tumour cell clones [38].

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