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Gene Review

SLC9A9  -  solute carrier family 9, subfamily A (NHE9...

Homo sapiens

Synonyms: AUTS16, FLJ35613, NHE-9, NHE9, Na(+)/H(+) exchanger 9, ...
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High impact information on SLC9A9

  • We identified NHE6 in a subset of hair bundles; NHE9 was present in all bundles [1].
  • Electroneutral K+/H+ exchange, which we propose is performed by NHE9 in hair bundles, exploits the high-K+ endolymph, responds only to pH imbalance across the bundle membrane, is unaffected by the +80 mV endocochlear potential, and uses mechanisms already present in the ear for K+ recycling [1].
  • NHE6 and NHE9 are organellar isoforms that can appear transiently on plasma membranes and have been proposed to mediate K+/H+ exchange [1].
  • RESULTS: The amplification products were subsequently sequenced to reveal that the breakpoints lay within an intron of the dedicator of cytokinesis 3 (DOCK3) gene at the p arm breakpoint, and an intron of a novel member of the solute carrier family 9 (sodium/hydrogen exchanger) isoform 9 (SLC9A9) at the q arm [2].


  1. Vestibular hair bundles control pH with (Na+, K+)/H+ exchangers NHE6 and NHE9. Hill, J.K., Brett, C.L., Chyou, A., Kallay, L.M., Sakaguchi, M., Rao, R., Gillespie, P.G. J. Neurosci. (2006) [Pubmed]
  2. Disruption of a novel member of a sodium/hydrogen exchanger family and DOCK3 is associated with an attention deficit hyperactivity disorder-like phenotype. de Silva, M.G., Elliott, K., Dahl, H.H., Fitzpatrick, E., Wilcox, S., Delatycki, M., Williamson, R., Efron, D., Lynch, M., Forrest, S. J. Med. Genet. (2003) [Pubmed]
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