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Gene Review

SLC9A6  -  solute carrier family 9, subfamily A (NHE6...

Homo sapiens

Synonyms: KIAA0267, MRSA, NHE-6, NHE6, Na(+)/H(+) exchanger 6, ...
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High impact information on SLC9A6


Biological context of SLC9A6

  • These results suggest that, like its homologs in yeast and plants, NHE6 is an endosomal Na(+)/H(+) exchanger that may regulate intravesicular pH and volume and contribute to lysosomal biogenesis [3].

Anatomical context of SLC9A6


Other interactions of SLC9A6

  • 1. The SLC9A6 and FGF13 genes in this region, were selected and screened for mutation in this family, but no mutation was detected [6].
  • All, except NHE-6 and NHE-7, which are located intracellularly, are restricted to the sarcolemmal membrane [7].
  • Vestibular hair bundles control pH with (Na+, K+)/H+ exchangers NHE6 and NHE9 [8].
  • The NHE-1 subtype is the predominant isoform in the heart, but NHE-6 is also expressed in the heart [7].
  • The segmental location and function of NHE-5 and NHE-6 in the kidney are unknown at present [9].


  1. NHE6 protein possesses a signal peptide destined for endoplasmic reticulum membrane and localizes in secretory organelles of the cell. Miyazaki, E., Sakaguchi, M., Wakabayashi, S., Shigekawa, M., Mihara, K. J. Biol. Chem. (2001) [Pubmed]
  2. Identification of a mitochondrial Na+/H+ exchanger. Numata, M., Petrecca, K., Lake, N., Orlowski, J. J. Biol. Chem. (1998) [Pubmed]
  3. Human Na(+)/H(+) exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria. Brett, C.L., Wei, Y., Donowitz, M., Rao, R. Am. J. Physiol., Cell Physiol. (2002) [Pubmed]
  4. The myocardial Na+/H+ exchanger: a potential therapeutic target for the prevention of myocardial ischaemic and reperfusion injury and attenuation of postinfarction heart failure. Karmazyn, M., Sostaric, J.V., Gan, X.T. Drugs (2001) [Pubmed]
  5. Na(+)/H(+)exchangers: linking osmotic dysequilibrium to modified cell function. Ritter, M., Fuerst, J., Wöll, E., Chwatal, S., Gschwentner, M., Lang, F., Deetjen, P., Paulmichl, M. Cell. Physiol. Biochem. (2001) [Pubmed]
  6. Confirmation and refinement of a genetic locus of congenital motor nystagmus in Xq26.3-q27.1 in a Chinese family. Zhang, B., Xia, K., Ding, M., Liang, D., Liu, Z., Pan, Q., Hu, Z., Wu, L.Q., Cai, F., Xia, J. Hum. Genet. (2005) [Pubmed]
  7. NHE-1 inhibition: from protection during acute ischaemia/reperfusion to prevention/reversal of myocardial remodelling. Linz, W.J., Busch, A.E. Naunyn Schmiedebergs Arch. Pharmacol. (2003) [Pubmed]
  8. Vestibular hair bundles control pH with (Na+, K+)/H+ exchangers NHE6 and NHE9. Hill, J.K., Brett, C.L., Chyou, A., Kallay, L.M., Sakaguchi, M., Rao, R., Gillespie, P.G. J. Neurosci. (2006) [Pubmed]
  9. The Na+/H+ exchanger gene family. Burckhardt, G., Di Sole, F., Helmle-Kolb, C. J. Nephrol. (2002) [Pubmed]
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