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Gene Review:

DPH3 - diphthamide biosynthesis 3

Homo sapiens

Synonyms: CSL-type zinc finger-containing protein 2, DELGIP, DELGIP1, DESR1, DPH3 homolog, ...

Sjölinder, M. et al., Gestetner, B. et al.

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High impact information on DPH3

Downregulation of endogenous DelGIP1 in HeLa cells induced increased extracellular secretion of proteoglycans indicating a possible role for DelGIP1 in the secretion process [1].
A protein with a predicted size of 9 kDa was identified as a binding partner, this protein was designated DelGEF interacting protein 1 (DelGIP1) [1].
Proceedings: Studies on a cinnamic acid hydroxylase from chloroplasts of sweet clover, Melilotus alba desr [2].

Analytical, diagnostic and therapeutic context of DPH3

The human DelGIP1 gene is ubiquitously expressed as judged by human multiple tissue Northern blot analysis [1].

References

Characterisation of an evolutionary conserved protein interacting with the putative guanine nucleotide exchange factor DelGEF and modulating secretion. Sjölinder, M., Uhlmann, J., Ponstingl, H. Exp. Cell Res. (2004) [Pubmed]
Proceedings: Studies on a cinnamic acid hydroxylase from chloroplasts of sweet clover, Melilotus alba desr. Gestetner, B., Conn, E.E. Isr. J. Med. Sci. (1975) [Pubmed]

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