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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Melilotus

  • The sweet clover differed from alfalfa in nodulation by a mutant strain of R. meliloti, but the agglutinins were indistinguishable by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, Rhizobium agglutination, and cross-reactivity to antibodies [1].
  • Vitamin K3 levels of 0, 0.45, 4.5, 11, and 45 mg/kg body weight/day were fed to 173-235-kg steers consuming toxic (40-50 ppm dicumarol) sweet clover [2].

High impact information on Melilotus

  • Mutations in these genes affect nodulation of their natural plant hosts Medicago sativa and Melilotus albus to different extents and hsnD mutants have an altered host-range [3].
  • In exoA, -F, and -H mutants, which are deficient in normal succinoglycan secretion and nodule invasion, a transposon Tn5 insertion in mucR or the presence of pMuc resulted in EPSb secretion and a restoration of nodule invasion on Medicago sativa and Melilotus alba [4].
  • These experiments indicate that nodD1 and nodD3 have equivalent roles in nodulating sweet clover but that nodD1 plays a more important role than nodD3 in eliciting nodules on alfalfa [5].
  • The nodD2 gene appears to have some effect on alfalfa nodulation and none on sweet clover [5].
  • The expression of MaEXP1, a Melilotus alba expansin gene, is upregulated during the sweetclover-Sinorhizobium meliloti interaction [6].

Biological context of Melilotus

  • R. meliloti strains containing mutations in the three nodD genes in all possible combinations were constructed and their nodulation phenotypes were assayed on Medicago sativa (alfalfa) and Melilotus alba (sweet clover) [5].
  • On particular hosts, such as Medicago littoralis, mutants of the n5 operon showed a very weak nodule-forming ability, associated with a drastic decrease in the number of infection threads, while nodulation of Medicago truncatula or Melilotus alba was not affected [7].

Associations of Melilotus with chemical compounds


Gene context of Melilotus


  1. Legume agglutinins that bind to Rhizobium meliloti. Seegers, R., LaRue, T.A. J. Bacteriol. (1985) [Pubmed]
  2. Evaluation of vitamin K3 feed additive for prevention of sweet clover disease. Casper, H.H., Alstad, A.D., Tacke, D.B., Johnson, L.J., Lloyd, W.E. J. Vet. Diagn. Invest. (1989) [Pubmed]
  3. Organization, structure and symbiotic function of Rhizobium meliloti nodulation genes determining host specificity for alfalfa. Horvath, B., Kondorosi, E., John, M., Schmidt, J., Török, I., Györgypal, Z., Barabas, I., Wieneke, U., Schell, J., Kondorosi, A. Cell (1986) [Pubmed]
  4. A second exopolysaccharide of Rhizobium meliloti strain SU47 that can function in root nodule invasion. Zhan, H.J., Levery, S.B., Lee, C.C., Leigh, J.A. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  5. Rhizobium meliloti has three functional copies of the nodD symbiotic regulatory gene. Honma, M.A., Ausubel, F.M. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  6. The expression of MaEXP1, a Melilotus alba expansin gene, is upregulated during the sweetclover-Sinorhizobium meliloti interaction. Giordano, W., Hirsch, A.M. Mol. Plant Microbe Interact. (2004) [Pubmed]
  7. In Rhizobium meliloti, the operon associated with the nod box n5 comprises nodL, noeA and noeB, three host-range genes specifically required for the nodulation of particular Medicago species. Ardourel, M., Lortet, G., Maillet, F., Roche, P., Truchet, G., Promé, J.C., Rosenberg, C. Mol. Microbiol. (1995) [Pubmed]
  8. Dicoumarol (moldy sweet clover) toxicosis in a group of Holstein calves. Yamini, B., Poppenga, R.H., Braselton, W.E., Judge, L.J. J. Vet. Diagn. Invest. (1995) [Pubmed]
  9. Bioextraction of selenium by forage and selected field legume species in selenium-laden soils under minimal field management conditions. Van Mantgem, P.J., Wu, L., Banuelos, G.S. Ecotoxicol. Environ. Saf. (1996) [Pubmed]
  10. A new oleanene glucuronide obtained from the aerial parts of Melilotus officinalis. Hirakawa, T., Okawa, M., Kinjo, J., Nohara, T. Chem. Pharm. Bull. (2000) [Pubmed]
  11. In vitro availability of kaempferol glycosides from cream formulations of methanolic extract of the leaves of Melilotus elegans. Gebre-Mariam, T., Asres, K., Getie, M., Endale, A., Neubert, R., Schmidt, P.C. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V. (2005) [Pubmed]
  12. Proceedings: Studies on a cinnamic acid hydroxylase from chloroplasts of sweet clover, Melilotus alba desr. Gestetner, B., Conn, E.E. Isr. J. Med. Sci. (1975) [Pubmed]
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