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Gene Review:

BDA20 - major allergen BDA20

Bos taurus

Virtanen, T. et al., Mäntyjärvi, R. et al., Rautiainen, J. et al.

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Disease relevance of BDA20

CONCLUSION: These findings suggest that purified BDA20 is better than BEA for diagnosing cow asthma and that proteins associated with milk allergy are of only marginal significance in this disease [1].

High impact information on BDA20

BDA20, a major bovine dander allergen characterized at the sequence level, is Bos d 2 [2].
RESULTS: In this article we report the cDNA and amino acid sequences of BDA20 [3].
OBJECTIVE: The study was performed to characterize the molecular structure of BDA20,* the predominant allergen in bovine dander [3].
In the lymphocyte proliferation analysis, cow asthma was more closely associated with reactivity to BDA20 than to BEA [1].

Analytical, diagnostic and therapeutic context of BDA20

OBJECTIVE: This study compares the performance of the purified major cow allergen (BDA20) and crude bovine epithelial extract (BEA) in diagnostic tests and examines the role of milk allergy-associated bovine proteins (bovine serum albumin, alpha-lactalbumin, beta-lactoglobulin, casein) in respiratory cow allergy [1].

References

Immune reactivity of cow-asthmatic dairy farmers to the major allergen of cow (BDA20) and to other cow-derived proteins. The use of purified BDA20 increases the performance of diagnostic tests in respiratory cow allergy. Virtanen, T., Zeiler, T., Rautiainen, J., Taivainen, A., Pentikäinen, J., Rytkönen, M., Parkkinen, S., Pelkonen, J., Mäntyjärvi, R. Clin. Exp. Allergy (1996) [Pubmed]
BDA20, a major bovine dander allergen characterized at the sequence level, is Bos d 2. Rautiainen, J., Rytkönen, M., Virtanen, T., Pentikäinen, J., Zeiler, T., Mäntyjärvi, R. J. Allergy Clin. Immunol. (1997) [Pubmed]
Complementary DNA cloning of the predominant allergen of bovine dander: a new member in the lipocalin family. Mäntyjärvi, R., Parkkinen, S., Rytkönen, M., Pentikäinen, J., Pelkonen, J., Rautiainen, J., Zeiler, T., Virtanen, T. J. Allergy Clin. Immunol. (1996) [Pubmed]

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MGC151921	Bos taurus
LOC100300091	Bos taurus
Gm14743	Mus musculus
Gm5938	Mus musculus
Obp1a	Mus musculus
Obp1b	Mus musculus

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