The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Milk Hypersensitivity

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Milk Hypersensitivity

 

High impact information on Milk Hypersensitivity

  • Fourteen children, aged 2 to 15 years, with milk allergy and concomitant allergies to one or more foods were given cromolyn or placebo [6].
  • BACKGROUND: Large, prospective population-based studies on clinical course, development of tolerance, and risk for other atopy in children with cow's milk allergy (CMA) are lacking [7].
  • Cow's milk-specific T-cell reactivity of children with and without persistent cow's milk allergy: key role for IL-10 [8].
  • BACKGROUND: Fortification of milk with vitamin D may not be adequate for satisfying the vitamin D requirement because of variability in vitamin D content after fortification and because many persons have milk allergy or lactose intolerance [9].
  • Cell-surface expression of CD25, CD26, and CD30 by allergen-specific T cells is intrinsically different in cow's milk allergy [10].
 

Chemical compound and disease context of Milk Hypersensitivity

 

Anatomical context of Milk Hypersensitivity

  • CD4 CD25 regulatory T cells are not functionally impaired in adult patients with IgE-mediated cow's milk allergy [16].
  • Eosinophils are uncommonly detected in human milk and their presence has previously been associated with maternal atopy and development of cow's milk allergy (CMA) in the breast-fed infant [17].
  • Positive control sera were obtained from patients with well-documented histories of cow's milk allergy, while negative control sera were obtained from cord bloods of healthy full-term infants and from normal adult volunteers without known milk allergy [18].
  • The proliferation of casein-stimulated lymphocytes from children reacting to cow's milk (age 0.7-5.9 years) was significantly higher (P < 0.01) than the proliferation of lymphocytes from 15 children with AD without milk allergy (age: 2.1-9.1 years) [19].
  • Soluble serum CD23 levels and CD23 molecule expression on intestinal epithelial cells in infants with reaginic and non reaginic cow's milk allergy [20].
 

Gene context of Milk Hypersensitivity

  • These results show a general enhancement of Th1 and Th2-type cytokine-secreting cells in the blood of children with cow's milk hypersensitivity, although the increased IL-4-secreting cells in blood in CMA may be of relevance in view of the fact that this disease is IgE-mediated [21].
  • Increased IFN-gamma secretion from duodenal biopsy samples in delayed-type cow's milk allergy [22].
  • The glcNAc/glc lectin showed a strong preferential recognition of CD jejunal tissue but also bound with less intensity to specimens from patients with cow milk allergies and healthy children [23].
  • CONCLUSION: These findings suggest that purified BDA20 is better than BEA for diagnosing cow asthma and that proteins associated with milk allergy are of only marginal significance in this disease [24].
  • TNF-alpha and IFN-gamma production of PBMC was significantly lower in infants with cow's milk allergy than in healthy children [25].
 

Analytical, diagnostic and therapeutic context of Milk Hypersensitivity

  • METHODS: The casein content of 30 NRL glove extracts (1:5 wt/vol) was measured by RAST inhibition and by rocket immunoelectrophoresis and rocket radioimmunoelectrophoresis by using casein-specific rabbit antiserum, a serum pool from patients with cow's milk allergy, and radiolabeled anti-human IgE [26].
  • The atopy patch tests for detection of cow's milk allergy with digestive symptoms [27].
  • In addition, sera from 16 patients with documented egg and/or cows' milk hypersensitivity and two controls who were not allergic to egg or milk were used to assess potential allergenicity/antigenicity of these products by immunoblot (Western blot) analysis [28].
  • Double-blind, placebo controlled food challenge, the definitive diagnostic test for cow's milk allergy, is increasingly being replaced by the measurement of food-specific antibodies, in combination with skin-prick or atopy patch testing [29].

References

  1. Milk-induced eczema is associated with the expansion of T cells expressing cutaneous lymphocyte antigen. Abernathy-Carver, K.J., Sampson, H.A., Picker, L.J., Leung, D.Y. J. Clin. Invest. (1995) [Pubmed]
  2. Lactobacillus GG effect in increasing IFN-gamma production in infants with cow's milk allergy. Pohjavuori, E., Viljanen, M., Korpela, R., Kuitunen, M., Tiittanen, M., Vaarala, O., Savilahti, E. J. Allergy Clin. Immunol. (2004) [Pubmed]
  3. Markedly high eosinophilia and an elevated serum IL-5 level in an infant with cow milk allergy. Matsumoto, T., Goto, Y., Miike, T. Ann. Allergy Asthma Immunol. (1999) [Pubmed]
  4. In vivo and in vitro studies on the residual allergenicity of partially hydrolysed infant formulae. Niggemann, B., Binder, C., Klettke, U., Wahn, U. Acta Paediatr. (1999) [Pubmed]
  5. Food allergies in children affect nutrient intake and growth. Christie, L., Hine, R.J., Parker, J.G., Burks, W. Journal of the American Dietetic Association. (2002) [Pubmed]
  6. Use of cromolyn in combined gastrointestinal allergy. Kocoshis, S., Gryboski, J.D. JAMA (1979) [Pubmed]
  7. Clinical course and prognosis of cow's milk allergy are dependent on milk-specific IgE status. Saarinen, K.M., Pelkonen, A.S., Mäkelä, M.J., Savilahti, E. J. Allergy Clin. Immunol. (2005) [Pubmed]
  8. Cow's milk-specific T-cell reactivity of children with and without persistent cow's milk allergy: key role for IL-10. Tiemessen, M.M., Van Ieperen-Van Dijk, A.G., Bruijnzeel-Koomen, C.A., Garssen, J., Knol, E.F., Van Hoffen, E. J. Allergy Clin. Immunol. (2004) [Pubmed]
  9. Fortification of orange juice with vitamin D: a novel approach for enhancing vitamin D nutritional health. Tangpricha, V., Koutkia, P., Rieke, S.M., Chen, T.C., Perez, A.A., Holick, M.F. Am. J. Clin. Nutr. (2003) [Pubmed]
  10. Cell-surface expression of CD25, CD26, and CD30 by allergen-specific T cells is intrinsically different in cow's milk allergy. Schade, R.P., Van Ieperen-Van Dijk, A.G., Versluis, C., Van Reijsen, F.C., Kimpen, J.L., Bruijnzeel-Koomen, C.A., Knol, E.F., Van Hoffen, E. J. Allergy Clin. Immunol. (2002) [Pubmed]
  11. Cow's milk allergy in breast-fed infants: the role of allergen and maternal secretory IgA antibody. Machtinger, S., Moss, R. J. Allergy Clin. Immunol. (1986) [Pubmed]
  12. The mucosal adhesion receptor alpha4beta7 integrin is selectively increased in lymphocytes stimulated with beta-lactoglobulin in children allergic to cow's milk. Eigenmann, P.A., Tropia, L., Hauser, C. J. Allergy Clin. Immunol. (1999) [Pubmed]
  13. Diagnosis of cow's milk allergy avoided melatonin intake in infant with insomnia. Pajno, G.B., Barberio, F., Vita, D., Caminiti, L., Capristo, C., Adelardi, S., Zirilli, G. Sleep. (2004) [Pubmed]
  14. Effect of terfenadine on TNF alpha release from peripheral blood mononuclear cells during cow's milk allergy. Benlounes, N., Dupont, C., Candalh, C., Blaton, M.A., Bloom, M., Heyman, M. Clin. Exp. Allergy (1997) [Pubmed]
  15. Egg and milk allergy in adults: comparison between fresh foods and commercial allergen extracts in skin prick test and histamine release from basophils. Norgaard, A., Skov, P.S., Bindslev-Jensen, C. Clin. Exp. Allergy (1992) [Pubmed]
  16. CD4 CD25 regulatory T cells are not functionally impaired in adult patients with IgE-mediated cow's milk allergy. Tiemessen, M.M., Van Hoffen, E., Knulst, A.C., Van Der Zee, J.A., Knol, E.F., Taams, L.S. J. Allergy Clin. Immunol. (2002) [Pubmed]
  17. Eosinophil cationic protein in human milk is associated with development of cow's milk allergy and atopic eczema in breast-fed infants. Osterlund, P., Smedberg, T., Hakulinen, A., Heikkilä, H., Järvinen, K.M. Pediatr. Res. (2004) [Pubmed]
  18. Indirect enzyme-linked immunosorbent assay for measurement of human immunoglobulins E and G to purified cow's milk proteins: application in diagnosis of cow's milk allergy. Campbell, D.E., Ngamphaiboon, J., Clark, M.M., Harris, M.C., Kolski, G.B., Douglas, S.D. J. Clin. Microbiol. (1987) [Pubmed]
  19. The role of circulating food antigen-specific lymphocytes in food allergic children with atopic dermatitis. Reekers, R., Beyer, K., Niggemann, B., Wahn, U., Freihorst, J., Kapp, A., Werfel, T. Br. J. Dermatol. (1996) [Pubmed]
  20. Soluble serum CD23 levels and CD23 molecule expression on intestinal epithelial cells in infants with reaginic and non reaginic cow's milk allergy. Lachaux, A., Grosjean, I., Bonnefoy, J.Y., Kaiserlian, D. Eur. J. Pediatr. (1996) [Pubmed]
  21. The frequency of cells secreting interferon-gamma and interleukin-4, -5, and -10 in the blood and duodenal mucosa of children with cow's milk hypersensitivity. Hauer, A.C., Breese, E.J., Walker-Smith, J.A., MacDonald, T.T. Pediatr. Res. (1997) [Pubmed]
  22. Increased IFN-gamma secretion from duodenal biopsy samples in delayed-type cow's milk allergy. Paajanen, L., Vaarala, O., Karttunen, R., Tuure, T., Korpela, R., Kokkonen, J. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. (2005) [Pubmed]
  23. Reactivity of gliadin and lectins with celiac intestinal mucosa. Pittschieler, K., Ladinser, B., Petell, J.K. Pediatr. Res. (1994) [Pubmed]
  24. Immune reactivity of cow-asthmatic dairy farmers to the major allergen of cow (BDA20) and to other cow-derived proteins. The use of purified BDA20 increases the performance of diagnostic tests in respiratory cow allergy. Virtanen, T., Zeiler, T., Rautiainen, J., Taivainen, A., Pentikäinen, J., Rytkönen, M., Parkkinen, S., Pelkonen, J., Mäntyjärvi, R. Clin. Exp. Allergy (1996) [Pubmed]
  25. Defective tumor necrosis factor-alpha production in infants with cow's milk allergy. Osterlund, P., Järvinen, K.M., Laine, S., Suomalainen, H. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. (1999) [Pubmed]
  26. Cow's milk casein, a hidden allergen in natural rubber latex gloves. Ylitalo, L., Mäkinen-Kiljunen, S., Turjanmaa, K., Palosuo, T., Reunala, T. J. Allergy Clin. Immunol. (1999) [Pubmed]
  27. The atopy patch tests for detection of cow's milk allergy with digestive symptoms. De Boissieu, D., Waguet, J.C., Dupont, C. J. Pediatr. (2003) [Pubmed]
  28. The antigenicity and allergenicity of microparticulated proteins: Simplesse. Sampson, H.A., Cooke, S. Clin. Exp. Allergy (1992) [Pubmed]
  29. Cow's milk allergy in infancy. Heine, R.G., Elsayed, S., Hosking, C.S., Hill, D.J. Current opinion in allergy and clinical immunology. (2002) [Pubmed]
 
WikiGenes - Universities