Disease relevance of MGC116147

• We show that normal fibroblasts in response to anoxia induce several members of the C/EBP and ATF subfamilies of the bZIP (basic/leucine zipper domain) transcription factor class [1].

High impact information on MGC116147

• These findings suggest that the leucine zipper domain is required for the Par-4 protein to function in apoptosis [2].
• The deduced amino acid sequence of par-4 predicts a protein with a leucine zipper domain at its carboxy terminus [2].
• Repression is dependent on a region in LRF-1 that includes amino acids 40 to 84 (domain R) and the basic/leucine zipper domain [3].
• In contrast, homo-oligomerization of the leucine zipper domain from c-Myc was not detectable in cells [4].
• As confirmed by pull-down assays, ATF-4 associates via its conserved basic leucine zipper domain with the C termini of both GABA(B) receptor (GABA(B)R) 1 and GABA(B)R2 at a site which serves to assemble these receptor subunits in heterodimeric complexes [5].

Biological context of MGC116147

• Two regions, a leucine zipper domain and C-terminal region, are conserved in the fos gene family [6].

Anatomical context of MGC116147

• The leucine zipper domain and two basic amino acid portions that bind DNA, as well as peptide sequences recognized by human cytotoxic T lymphocytes (CTLs), were all conserved in these rodent genes [7].

References