The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Atf4  -  activating transcription factor 4

Rattus norvegicus

Synonyms: Activating transcription factor 4, Cyclic AMP-dependent transcription factor ATF-4, cAMP-dependent transcription factor ATF-4, rATF-4
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Atf4

  • The metabotropic GABAB receptor directly interacts with the activating transcription factor 4 [1].
  • As confirmed by pull-down assays, ATF-4 associates via its conserved basic leucine zipper domain with the C termini of both GABA(B) receptor (GABA(B)R) 1 and GABA(B)R2 at a site which serves to assemble these receptor subunits in heterodimeric complexes [1].
  • Thus, inhibitory metabotropic GABA(B)Rs may regulate activity-dependent gene expression via a direct interaction with ATF-4 [1].
  • Confocal fluorescence microscopy shows that GABA(B)R and ATF-4 are strongly coclustered in the soma and at the dendritic membrane surface of both cultured hippocampal neurons as well as retinal amacrine cells in vivo [1].
  • In oocyte coexpression assays short term signaling of GABA(B)Rs via G proteins was only marginally affected by the presence of the transcription factor, but ATF-4 was moderately stimulated in response to receptor activation in in vivo reporter assays [1].

Biological context of Atf4


Associations of Atf4 with chemical compounds

  • When superoxide was visualized with ethidium, signals for ATF-4 and superoxide overlapped in the same cells [2].
  • The immunoreactivities for p-PERK, p-eIF2alpha, ATF-4, and CHOP were increased at the ischemic peripheral region after MCAO, which were partially inhibited by dantrolene treatment [4].


  1. The metabotropic GABAB receptor directly interacts with the activating transcription factor 4. Nehring, R.B., Horikawa, H.P., El Far, O., Kneussel, M., Brandstätter, J.H., Stamm, S., Wischmeyer, E., Betz, H., Karschin, A. J. Biol. Chem. (2000) [Pubmed]
  2. Damage to the endoplasmic reticulum and activation of apoptotic machinery by oxidative stress in ischemic neurons. Hayashi, T., Saito, A., Okuno, S., Ferrand-Drake, M., Dodd, R.L., Chan, P.H. J. Cereb. Blood Flow Metab. (2005) [Pubmed]
  3. Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress. Kharroubi, I., Ladrière, L., Cardozo, A.K., Dogusan, Z., Cnop, M., Eizirik, D.L. Endocrinology (2004) [Pubmed]
  4. The protective effect of dantrolene on ischemic neuronal cell death is associated with reduced expression of endoplasmic reticulum stress markers. Li, F., Hayashi, T., Jin, G., Deguchi, K., Nagotani, S., Nagano, I., Shoji, M., Chan, P.H., Abe, K. Brain Res. (2005) [Pubmed]
WikiGenes - Universities