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Gene Review

pcaU  -  regulatory protein for pca operon (activator)

Acinetobacter sp. ADP1

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Disease relevance of pcaU

  • Native PcaU was purified after overexpression of the pcaU gene in Escherichia coli [1].
  • Two different binding sites for Pseudomonas putida PcaR differ from the consensus in only a single nucleotide residue, and DNA directly downstream from Acinetobacter pcaU contains a 19-bp segment differing from the consensus in only two residues [2].

High impact information on pcaU

  • The increase of the pcaU gene copy number leads to a decrease of the basal expression at pcaIp, indicating that the occupancy of the PcaU binding site is well balanced and depends on the concentration of PcaU in the cell [3].
  • A PcaU binding site downstream of pcaU is covered by PcaU across two palindromic sequence repetitions [1].
  • Expression at the pcaU gene promoter is independent of the growth condition but is subject to strong negative autoregulation [4].
  • Downstream from pcaU are two open reading frames encoding proteins similar in amino acid sequence to those associated with the oxidation of acyl thioesters [2].
  • Inactivation of pcaU reduced the induced expression of pca structural genes by about 90% and impeded but did not completely prevent growth of the mutant cells with protocatechuate [2].


  1. Differential DNA binding of transcriptional regulator PcaU from Acinetobacter sp. strain ADP1. Popp, R., Kohl, T., Patz, P., Trautwein, G., Gerischer, U. J. Bacteriol. (2002) [Pubmed]
  2. PcaU, a transcriptional activator of genes for protocatechuate utilization in Acinetobacter. Gerischer, U., Segura, A., Ornston, L.N. J. Bacteriol. (1998) [Pubmed]
  3. Multiple-Level Regulation of Genes for Protocatechuate Degradation in Acinetobacter baylyi Includes Cross-Regulation. Siehler, S.Y., Dal, S., Fischer, R., Patz, P., Gerischer, U. Appl. Environ. Microbiol. (2007) [Pubmed]
  4. Effects exerted by transcriptional regulator PcaU from Acinetobacter sp. strain ADP1. Trautwein, G., Gerischer, U. J. Bacteriol. (2001) [Pubmed]
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