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Gene Review:

aceA - isocitrate lyase

Acinetobacter sp. ADP1

Hautzel, R. et al., Hoyt, J.C. et al., Barbaro, S.E. et al., van Schie, B.J. et al.

Barbaro, Trevors, Inniss,

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Disease relevance of aceA

Phosphorylation of Acinetobacter isocitrate lyase [1].

High impact information on aceA

Addition of acetate to a lag-phase culture grown on succinate causes a dramatic increase in activity of form II of isocitrate dehydrogenase and in isocitrate lyase [1].
This phenomenon was accompanied by the appearance of gluconate kinase and a repression of isocitrate lyase synthesis [2].
Mycenon (C11H5Cl3O3), a new inhibitor of isocitrate lyase (EC 4.1.3.1) was isolated from the culture broth of a basidiomycete, Mycena sp. Mycenon is a novel chlorinated benzoquinone derivative which is also active against bacteria and fungi [3].

Biological context of aceA

This report describes the phosphorylation of the enzyme isocitrate lyase from A. calcoaceticus [1].

Associations of aceA with chemical compounds

Mycenon, a new metabolite from a Mycena species TA 87202 (basidiomycetes) as an inhibitor of isocitrate lyase [3].

Analytical, diagnostic and therapeutic context of aceA

During growth at 25 degreesC, isocitrate lyase activity was detected in cell-free extracts, but at 5 degreesC and after cold shock, activity was measured primarily in the cell culture supernatant [4].

References

Phosphorylation of Acinetobacter isocitrate lyase. Hoyt, J.C., Reeves, H.C. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
Selection of glucose-assimilating variants of Acinetobacter calcoaceticus LMD 79.41 in chemostat culture. van Schie, B.J., Rouwenhorst, R.J., van Dijken, J.P., Kuenen, J.G. Antonie Van Leeuwenhoek (1989) [Pubmed]
Mycenon, a new metabolite from a Mycena species TA 87202 (basidiomycetes) as an inhibitor of isocitrate lyase. Hautzel, R., Anke, H., Sheldrick, W.S. J. Antibiot. (1990) [Pubmed]
Effects of low temperature, cold shock, and various carbon sources on esterase and lipase activities and exopolysaccharide production by a psychrotrophic Acinetobacter sp. Barbaro, S.E., Trevors, J.T., Inniss, W.E. Can. J. Microbiol. (2001) [Pubmed]

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