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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ampC  -  beta-lactamase

Acinetobacter sp. ADP1

 
 
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Disease relevance of ampC

 

High impact information on ampC

  • In all of the resistant isolates (groups II and III), but not in any of the ceftazidime-susceptible isolates (group I), a 1180 bp insert showing all the characteristics of an insertion sequence was detected upstream from the ampC gene [2].
  • OBJECTIVE: To compare the genetic environments of ampC genes in different Acinetobacter baumannii isolates showing different levels of beta-lactam resistance [2].
 

Analytical, diagnostic and therapeutic context of ampC

  • Isolates having this insert overexpress ampC, according to RT-PCR experiments [2].
  • The ampC gene and its 5' adjacent sequence were analysed by PCR and DNA sequencing [2].

References

  1. Genetic environment and transcription of ampC in an Acinetobacter baumannii clinical isolate. Segal, H., Nelson, E.C., Elisha, B.G. Antimicrob. Agents Chemother. (2004) [Pubmed]
  2. AmpC cephalosporinase hyperproduction in Acinetobacter baumannii clinical strains. Corvec, S., Caroff, N., Espaze, E., Giraudeau, C., Drugeon, H., Reynaud, A. J. Antimicrob. Chemother. (2003) [Pubmed]
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