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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

beta-Lactam Resistance

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Disease relevance of beta-Lactam Resistance


High impact information on beta-Lactam Resistance


Chemical compound and disease context of beta-Lactam Resistance


Biological context of beta-Lactam Resistance


Associations of beta-Lactam Resistance with chemical compounds

  • We conclude that, with the notable exception of imipenem, the MexAB-OprM pump contributes significantly to beta-lactam resistance in both beta-lactamase-negative and beta-lactamase-inducible strains, while the contribution of the MexAB-OprM efflux system is negligible in strains with overexpressed beta-lactamase [17].
  • Transformation of broad-spectrum beta-lactam resistance into ampicillin-susceptible H. influenzae RDnov was accomplished [18].
  • These studies suggest that beta-lactamase is the major mechanism of beta-lactam resistance in this species and that Augmentin is the first oral beta-lactam with good potential for treating infections due to N. brasiliensis [19].
  • The increases in the Ki values of both clavulanic acid and tazobactam for the enzyme with the triple mutation were consistent with the observed bacterial resistance to the reversibility of beta-lactam resistance with these inhibitors [20].
  • Subculturing of the four strains with decreased penicillin susceptibility in amoxicillin (with or without clavulanate) or cefuroxime did not select for beta-lactam resistance [21].

Gene context of beta-Lactam Resistance

  • Resistance to other, unrelated, antimicrobials, except notably the fluoroquinolones, was strongly associated with beta-lactam resistance. beta-lactamase production was detected in 492 isolates of H. influenzae, an overall prevalence of 18.1% [22].
  • Even though mutations in another gene(s) may be involved in beta-lactam resistance, these data indicate that mutations in the ftsI gene are the most important for development of resistance to beta-lactams in BLNAR strains [23].
  • Detection of an IS21 insertion sequence in the mexR gene of Pseudomonas aeruginosa increasing beta-lactam resistance [24].
  • The PBP 5 variants of 15 clinical isolates (including 8 resistant to vancomycin) with different levels of beta-lactam resistance were analyzed [12].
  • Overexpression of the efflux pump alone contributes to the high level of beta-lactam resistance in the absence of beta-lactamase [17].

Analytical, diagnostic and therapeutic context of beta-Lactam Resistance

  • The molecular mechanisms of beta-lactam resistance mediated by AmpC hyperproduction in natural strains of Pseudomonas aeruginosa were investigated in a collection of 10 isogenic, ceftazidime-susceptible and -resistant pairs of isolates, each sequentially recovered from a different intensive care unit patient treated with beta-lactams [25].


  1. Multiple beta-lactam resistance in Enterobacter cloacae following ceftazidime monotherapy. Black, A.S., Cohen, J. Lancet (1985) [Pubmed]
  2. Consumption of imipenem correlates with beta-lactam resistance in Pseudomonas aeruginosa. Lepper, P.M., Grusa, E., Reichl, H., Högel, J., Trautmann, M. Antimicrob. Agents Chemother. (2002) [Pubmed]
  3. Beta-lactam resistance mechanisms of methicillin-resistant Staphylococcus aureus. Franciolli, M., Bille, J., Glauser, M.P., Moreillon, P. J. Infect. Dis. (1991) [Pubmed]
  4. Role of penicillin-binding protein 5 in expression of ampicillin resistance and peptidoglycan structure in Enterococcus faecium. Sifaoui, F., Arthur, M., Rice, L., Gutmann, L. Antimicrob. Agents Chemother. (2001) [Pubmed]
  5. A multicomponent system is required for tetracycline-induced excision of Tn4555. Parker, A.C., Smith, C.J. J. Bacteriol. (2004) [Pubmed]
  6. Pneumococcal beta-lactam resistance due to a conformational change in penicillin-binding protein 2x. Carapito, R., Chesnel, L., Vernet, T., Zapun, A. J. Biol. Chem. (2006) [Pubmed]
  7. Synthesis of the L-alanyl-L-alanine cross-bridge of Enterococcus faecalis peptidoglycan. Bouhss, A., Josseaume, N., Severin, A., Tabei, K., Hugonnet, J.E., Shlaes, D., Mengin-Lecreulx, D., Van Heijenoort, J., Arthur, M. J. Biol. Chem. (2002) [Pubmed]
  8. Ciprofloxacin therapy in cystic fibrosis. Scully, B.E., Nakatomi, M., Ores, C., Davidson, S., Neu, H.C. Am. J. Med. (1987) [Pubmed]
  9. High-level beta-lactam resistance associated with acquired multidrug resistance in Helicobacter pylori. Kwon, D.H., Dore, M.P., Kim, J.J., Kato, M., Lee, M., Wu, J.Y., Graham, D.Y. Antimicrob. Agents Chemother. (2003) [Pubmed]
  10. Mechanism of chloramphenicol and beta-lactam resistance in clinical isolates of Yersinia enterocolitica. Rivera, M.J., Castillo, J., Madero, P., Otal, I., Pèrez-Trallero, E., Gòmez-Lus, R. Journal of chemotherapy (Florence, Italy) (1989) [Pubmed]
  11. Selection of cefoxitin-resistant bacteroides thetaiotaomicron mutants and mechanisms involved in beta-lactam resistance. Fang, H., Edlund, C., Nord, C.E., Hedberg, M. Clin. Infect. Dis. (2002) [Pubmed]
  12. Penicillin-binding protein 5 sequence alterations in clinical isolates of Enterococcus faecium with different levels of beta-lactam resistance. Rybkine, T., Mainardi, J.L., Sougakoff, W., Collatz, E., Gutmann, L. J. Infect. Dis. (1998) [Pubmed]
  13. Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus. Ito, T., Katayama, Y., Asada, K., Mori, N., Tsutsumimoto, K., Tiensasitorn, C., Hiramatsu, K. Antimicrob. Agents Chemother. (2001) [Pubmed]
  14. Random amplified polymorphic DNA and phenotyping analysis of Salmonella enterica serovar enteritidis isolates collected from humans and poultry in Uruguay from 1995 to 2002. Betancor, L., Schelotto, F., Martinez, A., Pereira, M., Algorta, G., Rodríguez, M.A., Vignoli, R., Chabalgoity, J.A. J. Clin. Microbiol. (2004) [Pubmed]
  15. R-plasmid mediated transfer of beta-lactam resistance in Bacteroides fragilis. Yamaoka, K., Watanabe, K., Muto, Y., Katoh, N., Ueno, K., Tally, F.P. J. Antibiot. (1990) [Pubmed]
  16. Emergence of unusual species of enterococci causing infections, South India. Prakash, V.P., Rao, S.R., Parija, S.C. BMC Infect. Dis. (2005) [Pubmed]
  17. Resistance to beta-lactam antibiotics in Pseudomonas aeruginosa due to interplay between the MexAB-OprM efflux pump and beta-lactamase. Nakae, T., Nakajima, A., Ono, T., Saito, K., Yoneyama, H. Antimicrob. Agents Chemother. (1999) [Pubmed]
  18. Mechanism of resistance of an ampicillin-resistant, beta-lactamase-negative clinical isolate of Haemophilus influenzae type b to beta-lactam antibiotics. Parr, T.R., Bryan, L.E. Antimicrob. Agents Chemother. (1984) [Pubmed]
  19. Beta-lactam resistance in Nocardia brasiliensis is mediated by beta-lactamase and reversed in the presence of clavulanic acid. Wallace, R.J., Nash, D.R., Johnson, W.K., Steele, L.C., Steingrube, V.A. J. Infect. Dis. (1987) [Pubmed]
  20. Mutant TEM beta-lactamase producing resistance to ceftazidime, ampicillins, and beta-lactamase inhibitors. Vakulenko, S., Golemi, D. Antimicrob. Agents Chemother. (2002) [Pubmed]
  21. In vitro selection of resistance to four beta-lactams and azithromycin in Streptococcus pneumoniae. Pankuch, G.A., Jueneman, S.A., Davies, T.A., Jacobs, M.R., Appelbaum, P.C. Antimicrob. Agents Chemother. (1998) [Pubmed]
  22. A multicentre collaborative study of the antimicrobial susceptibility of community-acquired, lower respiratory tract pathogens 1992-1993: the Alexander Project. Felmingham, D., Grüneberg, R.N. J. Antimicrob. Chemother. (1996) [Pubmed]
  23. Association of amino acid substitutions in penicillin-binding protein 3 with beta-lactam resistance in beta-lactamase-negative ampicillin-resistant Haemophilus influenzae. Ubukata, K., Shibasaki, Y., Yamamoto, K., Chiba, N., Hasegawa, K., Takeuchi, Y., Sunakawa, K., Inoue, M., Konno, M. Antimicrob. Agents Chemother. (2001) [Pubmed]
  24. Detection of an IS21 insertion sequence in the mexR gene of Pseudomonas aeruginosa increasing beta-lactam resistance. Boutoille, D., Corvec, S., Caroff, N., Giraudeau, C., Espaze, E., Caillon, J., Plésiat, P., Reynaud, A. FEMS Microbiol. Lett. (2004) [Pubmed]
  25. Molecular mechanisms of beta-lactam resistance mediated by AmpC hyperproduction in Pseudomonas aeruginosa clinical strains. Juan, C., Maciá, M.D., Gutiérrez, O., Vidal, C., Pérez, J.L., Oliver, A. Antimicrob. Agents Chemother. (2005) [Pubmed]
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