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Gene Review: 

IGKV1-12  -  immunoglobulin kappa variable 1-12

Homo sapiens

Synonyms: IGKV112, L19
 
 
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Disease relevance of IGKV1-12

  • Previously we showed in Salmonella typhimurium that the fitness cost, i.e. reduced growth rate, due to the amino acid substitution K42N in S12 could be compensated by at least 35 different mutations located in the ribosomal proteins S4, S5 and L19 [1].
 

High impact information on IGKV1-12

  • When separated from the resistance mutation located in S12, the three different compensatory amino acid substitutions in L19 at position 40 (Q40H, Q40L and Q40R) caused a decrease in fitness while the G104A change had no effect on bacterial growth [1].
 

Analytical, diagnostic and therapeutic context of IGKV1-12

  • The same animal model was used to study the therapeutic action of the L19 antibody fused to the cytokines IL-2, tumour necrosis factor (TNF) and IL-10 [2].

References

  1. Compensatory Evolution Reveals Functional Interactions between Ribosomal Proteins S12, L14 and L19. Maisnier-Patin, S., Paulander, W., Pennhag, A., Andersson, D.I. J. Mol. Biol. (2007) [Pubmed]
  2. Antibody-mediated delivery of IL-10 inhibits the progression of established collagen-induced arthritis. Trachsel, E., Bootz, F., Silacci, M., Kaspar, M., Kosmehl, H., Neri, D. Arthritis Res. Ther. (2007) [Pubmed]
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