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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DCPS  -  decapping enzyme, scavenger

Homo sapiens

Synonyms: DCS-1, DCS1, Decapping scavenger enzyme, HINT-5, HINT5, ...
 
 
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Disease relevance of DCPS

  • After having received a total of 14 to 48 DCPS, further treatment for pemphigus was withdrawn [1].
 

High impact information on DCPS

  • The resulting Dcs2 protein forms a heterodimer together with Dcs1, both modulating Dcs1 substrate specificity and suppressing its k(cat) [2].
  • Furthermore, we show that a novel human histidine triad protein DCS-1, which is expressed together with NR1 in many tissues, can significantly reduce menadione-induced cytotoxicity in these cells [3].
  • We also show that DCS-1 binds NF1 and directly modulates its activity [3].
  • Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity [3].
  • In between the DCPS, the patient receives only 50 mg cyclophosphamide orally daily and generally no corticosteroids [4].

References

  1. Curative effect of dexamethasone-cyclophosphamide pulse therapy for the treatment of pemphigus vulgaris. Pasricha, J.S., Das, S.S. International journal of dermatology. (1992) [Pubmed]
  2. Dcs2, a Novel Stress-induced Modulator of m(7)GpppX Pyrophosphatase Activity that Locates to P Bodies. Malys, N., McCarthy, J.E. J. Mol. Biol. (2006) [Pubmed]
  3. Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity. Kwaśnicka-Crawford, D.A., Vincent, S.R. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  4. Dexamethasone-cyclophosphamide pulse therapy for pemphigus. Pasricha, J.S., Khaitan, B.K., Raman, R.S., Chandra, M. International journal of dermatology. (1995) [Pubmed]
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