The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

BLVRB  -  biliverdin reductase B

Homo sapiens

Synonyms: BVR-B, BVRB, Biliverdin reductase B, Biliverdin-IX beta-reductase, FLR, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of BLVRB

  • The FR protein was localized to mitochondria and suppressed the growth of colon cancer cells when over-expressed [1].
  • We tested the hypothesis that transduction of FR cDNA in sense or antisense orientation using recombinant adeno-associated virus modulated FR expression and altered proliferation of cervical carcinoma cells (which constitutively overexpress FR genes) [2].
  • A core region of the P1 promoter was sufficient for maximal promoter activity in ovarian carcinoma cell lines but not in OSE cells or in alpha FR-nonexpressing cell lines [3].
  • CONCLUSIONS: Before elective right hepatectomy, the hypertrophy of FLR induced by PVE had no beneficial effect on the postoperative course in patients with normal liver [4].
  • RESULTS: The mean increase of FLR and %FFLR 4 to 8 weeks after PVE were respectively 44 +/- 19% and 16 +/- 7% for patients with normal liver and 35 +/- 28% and 9 +/- 3% for those with chronic liver disease [4].

Psychiatry related information on BLVRB

  • Contrary to what is seen in normal individuals, no correlation was found between BMI and serum GHBP levels in anorexia nervosa patients [5].

High impact information on BLVRB

  • FR-alpha expression in Jurkat cells facilitated MBG or EBO entry, and FR-blocking reagents inhibited infection by MBG or EBO [6].
  • However, the molecular mechanisms controlling this interaction, especially within the context of FR regulation and folate status, have remained obscure [7].
  • Human cervical carcinoma cells exhibited progressively increasing upregulation of FRs after shifting of folate-replete cells to low-folate media, without a proportionate rise in FR mRNA or rise in hnRNP E1 [7].
  • Abrupt reversal of folate deficiency also led to a rapid parallel reduction in homocysteine and FR biosynthesis to levels observed in folate-replete cells [7].
  • The locus of mutation D112G was found within site 2 of the GH molecule in binding with GH receptor (GHR)/GH binding protein (GHBP) [8].

Chemical compound and disease context of BLVRB

  • Therefore, these results suggest that endogenous estrogen status may be an important determinant of the changes in GHBP levels in women with different body weights [9].
  • Neither GH administration to GH-deficient and normal subjects, nor octreotide treatment of patients with acromegaly, significantly altered GHBP activity [10].
  • The soluble fumarate reductase (FR) from Shewanella frigidimarina can catalyse the reduction of 2-methylfumarate with a k(cat) of 9.0 s(-1) and a K(M) of 32 microM [11].
  • BACKGROUND: Selective transarterial chemoembolization (TACE) and portal vein embolization (PVE) could improve the rate of hypertrophy of the future liver remnant (FLR) in patients with chronic liver disease [12].
  • To further elucidate the mechanisms underlying pubertal growth, we treated 14 boys with delayed puberty and short stature with either T (n = 7) or 5alpha-dihydrotestosterone (DHT) (n = 7) and compared the effect on plasma concentrations of GH, IGF-I, and GH binding protein (GHBP) [13].

Biological context of BLVRB


Anatomical context of BLVRB

  • We have isolated flavin reductase from bovine erythrocytes and show that the activity co-elutes with biliverdin-IX beta reductase [17].
  • The alpha folate receptor (alpha FR) is a membrane glycoprotein that binds folates, and mediates their uptake and that of antifolate drugs. alpha FR is absent on ovarian surface epithelium (OSE) but is detectable during early transforming events in this epithelium, with increasing expression levels in association with tumor progression [3].
  • In isolation, the GHBP is inactive, although it does compete with the receptor for ligand binding in the extracellular space and therefore inhibits the cellular response to GH [18].
  • OBJECTIVE: To assess the impact of liver hypertrophy of the future liver remnant volume (FLR) induced by preoperative portal vein embolization (PVE) on the immediate postoperative complications after a standardized major liver resection [4].
  • Immunohistochemical staining for GHR and GHBP decreased with age; in 12-week-old normal rats, only the early maturing chondrocytes were stained [19].

Associations of BLVRB with chemical compounds


Physical interactions of BLVRB

  • Truncation of 17 amino acids decreased its affinity toward both hGHBP and GH receptors on intact IM-9 lymphocytes and in liver rat microsomal fraction and inhibited the formation of 1:2 complexes with hGHBP [22].

Other interactions of BLVRB


Analytical, diagnostic and therapeutic context of BLVRB


  1. Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells. Hwang, P.M., Bunz, F., Yu, J., Rago, C., Chan, T.A., Murphy, M.P., Kelso, G.F., Smith, R.A., Kinzler, K.W., Vogelstein, B. Nat. Med. (2001) [Pubmed]
  2. Transduction of folate receptor cDNA into cervical carcinoma cells using recombinant adeno-associated virions delays cell proliferation in vitro and in vivo. Sun, X.L., Murphy, B.R., Li, Q.J., Gullapalli, S., Mackins, J., Jayaram, H.N., Srivastava, A., Antony, A.C. J. Clin. Invest. (1995) [Pubmed]
  3. The variant hepatocyte nuclear factor 1 activates the P1 promoter of the human alpha-folate receptor gene in ovarian carcinoma. Tomassetti, A., Mangiarotti, F., Mazzi, M., Sforzini, S., Miotti, S., Galmozzi, E., Elwood, P.C., Canevari, S. Cancer Res. (2003) [Pubmed]
  4. Portal vein embolization before right hepatectomy: prospective clinical trial. Farges, O., Belghiti, J., Kianmanesh, R., Regimbeau, J.M., Santoro, R., Vilgrain, V., Denys, A., Sauvanet, A. Ann. Surg. (2003) [Pubmed]
  5. Multiple endocrine abnormalities of the growth hormone and insulin-like growth factor axis in patients with anorexia nervosa: effect of short- and long-term weight recuperation. Argente, J., Caballo, N., Barrios, V., Muñoz, M.T., Pozo, J., Chowen, J.A., Morandé, G., Hernández, M. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  6. Folate receptor-alpha is a cofactor for cellular entry by Marburg and Ebola viruses. Chan, S.Y., Empig, C.J., Welte, F.J., Speck, R.F., Schmaljohn, A., Kreisberg, J.F., Goldsmith, M.A. Cell (2001) [Pubmed]
  7. Translational upregulation of folate receptors is mediated by homocysteine via RNA-heterogeneous nuclear ribonucleoprotein E1 interactions. Antony, A., Tang, Y.S., Khan, R.A., Biju, M.P., Xiao, X., Li, Q.J., Sun, X.L., Jayaram, H.N., Stabler, S.P. J. Clin. Invest. (2004) [Pubmed]
  8. Biologically inactive growth hormone caused by an amino acid substitution. Takahashi, Y., Shirono, H., Arisaka, O., Takahashi, K., Yagi, T., Koga, J., Kaji, H., Okimura, Y., Abe, H., Tanaka, T., Chihara, K. J. Clin. Invest. (1997) [Pubmed]
  9. Blood growth hormone-binding protein levels in premenopausal and postmenopausal women: roles of body weight and estrogen levels. Bondanelli, M., Margutti, A., Ambrosio, M.R., Plaino, L., Cobellis, L., Petraglia, F., degli Uberti, E.C. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  10. Regulation of growth hormone binding protein in man: comparison of gel chromatography and immunoprecipitation methods. Ho, K.K., Valiontis, E., Waters, M.J., Rajkovic, I.A. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  11. Fumarate reductase: structural and mechanistic insights from the catalytic reduction of 2-methylfumarate. Wardrope, C., Mowat, C.G., Walkinshaw, M.D., Reid, G.A., Chapman, S.K. FEBS Lett. (2006) [Pubmed]
  12. Sequential arterial and portal vein embolizations before right hepatectomy in patients with cirrhosis and hepatocellular carcinoma. Ogata, S., Belghiti, J., Farges, O., Varma, D., Sibert, A., Vilgrain, V. The British journal of surgery. (2006) [Pubmed]
  13. Androgen regulation of growth hormone binding protein. Keenan, B.S., Richards, G.E., Mercado, M., Dallas, J.S., Eakman, G.D., Baumann, G. Metab. Clin. Exp. (1996) [Pubmed]
  14. Mapping of the newly identified biliverdin-IX beta reductase gene (BLVRB) to human chromosome 19q13.13-->q13.2 by fluorescence in situ hybridization. Saito, F., Yamaguchi, T., Komuro, A., Tobe, T., Ikeuchi, T., Tomita, M., Nakajima, H. Cytogenet. Cell Genet. (1995) [Pubmed]
  15. Structure of human biliverdin IXbeta reductase, an early fetal bilirubin IXbeta producing enzyme. Pereira, P.J., Macedo-Ribeiro, S., Párraga, A., Pérez-Luque, R., Cunningham, O., Darcy, K., Mantle, T.J., Coll, M. Nat. Struct. Biol. (2001) [Pubmed]
  16. Complete amino acid sequence of biliverdin-IX beta reductase from human liver. Yamaguchi, T., Komuro, A., Nakano, Y., Tomita, M., Nakajima, H. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  17. Evidence that biliverdin-IX beta reductase and flavin reductase are identical. Shalloe, F., Elliott, G., Ennis, O., Mantle, T.J. Biochem. J. (1996) [Pubmed]
  18. The growth hormone-binding protein is a location-dependent cytokine receptor transcriptional enhancer. Graichen, R., Sandstedt, J., Goh, E.L., Isaksson, O.G., Törnell, J., Lobie, P.E. J. Biol. Chem. (2003) [Pubmed]
  19. Localization and regulation of the growth hormone receptor and growth hormone-binding protein in the rat growth plate. Gevers, E.F., van der Eerden, B.C., Karperien, M., Raap, A.K., Robinson, I.C., Wit, J.M. J. Bone Miner. Res. (2002) [Pubmed]
  20. The function of superoxide dismutase during the enzymatic formation of the free radical of ribonucleotide reductase. Fontecave, M., Gräslund, A., Reichard, P. J. Biol. Chem. (1987) [Pubmed]
  21. The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis. Liu, G., Chen, X. Oncogene (2002) [Pubmed]
  22. N-terminal-truncated recombinant analogs of bovine placental lactogen: interaction with human and rat growth hormone receptors and insulin-like growth factor-I secretion mediated by somatogenic receptors in rat hepatocytes. Vashdi-Elberg, D., Staten, N.R., Sakal, E., Krivi, G.G., Gertler, A. Endocrinology (1995) [Pubmed]
  23. Cloning and nucleotide sequence of a cDNA of the human erythrocyte NADPH-flavin reductase. Chikuba, K., Yubisui, T., Shirabe, K., Takeshita, M. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  24. Inhibition of growth hormone bioactivity by recombinant human growth hormone-binding protein in the eluted stain assay system. Dattani, M.T., Hindmarsh, P.C., Brook, C.G., Robinson, I.C., Marshall, N.J. J. Endocrinol. (1994) [Pubmed]
  25. An interpretation of human diaphorase isozymes in terms of three gene loci DIA1, DIA2 and DIA3. Fisher, R.A., Edwards, Y.H., Putt, W., Potter, J., Hopkinson, D.A. Ann. Hum. Genet. (1977) [Pubmed]
  26. Analysis of binding properties between 20 kDa human growth hormone (hGH) and hGH receptor (hGHR): the binding affinity for hGHR extracellular domain and mode of receptor dimerization. Uchida, H., Banba, S., Wada, M., Matsumoto, K., Ikeda, M., Naito, N., Tanaka, E., Honjo, M. J. Mol. Endocrinol. (1999) [Pubmed]
  27. Molecular cloning and expression of human liver biliverdin-IX beta reductase. Komuro, A., Tobe, T., Hashimoto, K., Nakano, Y., Yamaguchi, T., Nakajima, H., Tomita, M. Biol. Pharm. Bull. (1996) [Pubmed]
  28. Monkey growth hormone (GH) receptor gene expression. Evidence for two mechanisms for the generation of the GH binding protein. Martini, J.F., Pezet, A., Guezennec, C.Y., Edery, M., Postel-Vinay, M.C., Kelly, P.A. J. Biol. Chem. (1997) [Pubmed]
WikiGenes - Universities