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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Osgep  -  O-sialoglycoprotein endopeptidase

Rattus norvegicus

Synonyms: Gcpl1, N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein Osgep, tRNA threonylcarbamoyladenosine biosynthesis protein Osgep
 
 
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Disease relevance of Osgep

  • A putative O-sialoglycoprotease (a homologue of Pasteurella haemolytica glycoprotease, gcp; abbreviated as Prsmg1/Gcpl1) gene consisting of 11 exons and 10 introns spanning 7.3 kb lies immediately adjacent to the Apex gene in a 5'-to-5' orientation [1].
  • O-Sialoglycoprotein endopeptidase treatment revealed that on carcinomas and cell lines, the epitope was present on O-glycans [2].
 

High impact information on Osgep

  • The protein is sensitive to O-sialoglycoprotein endopeptidase, indicating that it belongs to the class of sialomucin-like proteins [3].
  • HL-60 cell rolling was almost completely abolished by pretreatment with sialidase or monoclonal antibody (MoAb) AM-3 recognizing sLex, and was reduced by about 80% by O-sialoglycoprotein-endopeptidase (OSGP) [4].

References

  1. Genomic structure of the rat major AP endonuclease gene (Apex) with an adjacent putative O-sialoglycoprotease gene (Prsmg1/Gcpl1) and a processed Apex pseudogene (Apexp1). Yao, M., Akiyama, K., Tan, Y., Sarker, A.H., Ikeda, S., Alam, S.S., Tsutsui, K., Yoshida, M.C., Seki, S. Acta Med. Okayama (1999) [Pubmed]
  2. Tk, a new colon tumor-associated antigen resulting from altered O-glycosylation. Meichenin, M., Rocher, J., Galanina, O., Bovin, N., Nifantev, N., Sherman, A., Cassagnau, E., Heymann, M.F., Bara, J., Fraser, R.H., Le Pendu, J. Cancer Res. (2000) [Pubmed]
  3. Biochemical characterization and molecular cloning of a novel endothelial-specific sialomucin. Morgan, S.M., Samulowitz, U., Darley, L., Simmons, D.L., Vestweber, D. Blood (1999) [Pubmed]
  4. Sialylated O-glycans and L-selectin sequentially mediate myeloid cell rolling in vivo. Ley, K., Zakrzewicz, A., Hanski, C., Stoolman, L.M., Kansas, G.S. Blood (1995) [Pubmed]
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