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Chemical Compound Review

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Disease relevance of Sialomucin


High impact information on Sialomucin


Chemical compound and disease context of Sialomucin


Biological context of Sialomucin


Anatomical context of Sialomucin


Associations of Sialomucin with other chemical compounds


Gene context of Sialomucin

  • Neutralizing antibody to endothelial-associated E-selectin (a ligand for sialyl Le(x)) inhibited adhesion of metastatic cells to cytokine-activated hepatic endothelial cells, and inhibition of sialomucin with antisense to the MUC2 gene inhibited adhesion to E-selectin [28].
  • Overexpression of sialomucin complex, a rat homologue of MUC4, inhibits tumor killing by lymphokine-activated killer cells [29].
  • [3H]Glucosamine pulse-chase labeling studies using antibodies specific for a COOH-terminal unglycosylated region of the MUC1 mucin core peptides suggested that NCCM treatment of HT-29 LMM cells did not change the rate of MUC1-related sialomucin processing [30].
  • PEA3 transactivates the Muc4/sialomucin complex promoter in mammary epithelial and tumor cells [31].
  • Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells [32].

Analytical, diagnostic and therapeutic context of Sialomucin


  1. Anti-CD43 inhibition of T cell homing. McEvoy, L.M., Sun, H., Frelinger, J.G., Butcher, E.C. J. Exp. Med. (1997) [Pubmed]
  2. Anuria, omphalocele, and perinatal lethality in mice lacking the CD34-related protein podocalyxin. Doyonnas, R., Kershaw, D.B., Duhme, C., Merkens, H., Chelliah, S., Graf, T., McNagny, K.M. J. Exp. Med. (2001) [Pubmed]
  3. Cell surface sialomucin and resistance to natural cell-mediated cytotoxicity of rat mammary tumor ascites cells. Sherblom, A.P., Moody, C.E. Cancer Res. (1986) [Pubmed]
  4. Sialomucin and lytic susceptibility of rat mammary tumor ascites cells. Moriarty, J., Skelly, C.M., Bharathan, S., Moody, C.E., Sherblom, A.P. Cancer Res. (1990) [Pubmed]
  5. Complexity of MAM-6, an epithelial sialomucin associated with carcinomas. Hilkens, J., Buijs, F., Ligtenberg, M. Cancer Res. (1989) [Pubmed]
  6. Binding of L-selectin to the vascular sialomucin CD34. Baumheter, S., Singer, M.S., Henzel, W., Hemmerich, S., Renz, M., Rosen, S.D., Lasky, L.A. Science (1993) [Pubmed]
  7. CD34 and CD43 inhibit mast cell adhesion and are required for optimal mast cell reconstitution. Drew, E., Merzaban, J.S., Seo, W., Ziltener, H.J., McNagny, K.M. Immunity (2005) [Pubmed]
  8. PSGL-1-mediated adhesion of human hematopoietic progenitors to P-selectin results in suppression of hematopoiesis. Lévesque, J.P., Zannettino, A.C., Pudney, M., Niutta, S., Haylock, D.N., Snapp, K.R., Kansas, G.S., Berndt, M.C., Simmons, P.J. Immunity (1999) [Pubmed]
  9. Nepmucin, a novel HEV sialomucin, mediates L-selectin-dependent lymphocyte rolling and promotes lymphocyte adhesion under flow. Umemoto, E., Tanaka, T., Kanda, H., Jin, S., Tohya, K., Otani, K., Matsutani, T., Matsumoto, M., Ebisuno, Y., Jang, M.H., Fukuda, M., Hirata, T., Miyasaka, M. J. Exp. Med. (2006) [Pubmed]
  10. Effect of tunicamycin on sialomucin and natural killer susceptibility of rat mammary tumor ascites cells. Bharathan, S., Moriarty, J., Moody, C.E., Sherblom, A.P. Cancer Res. (1990) [Pubmed]
  11. Mechanism of expression of Thomsen-Friedenreich (T) antigen at the cell surface of a mammary adenocarcinoma. Hull, S.R., Carraway, K.L. FASEB J. (1988) [Pubmed]
  12. Biosynthesis of a tumor cell surface sialomucin. Maturation and effects of monensin. Spielman, J., Hull, S.R., Sheng, Z.Q., Kanterman, R., Bright, A., Carraway, K.L. J. Biol. Chem. (1988) [Pubmed]
  13. A new metabolite contributing to N-acetyl signal in 1H MRS of the brain in Salla disease. Varho, T., Komu, M., Sonninen, P., Holopainen, I., Nyman, S., Manner, T., Sillanpää, M., Aula, P., Lundbom, N. Neurology (1999) [Pubmed]
  14. Red cell aging. II. Anomalous electrophoretic properties of neuraminidase treated human erythrocytes. Nordt, F.J., Knox, R.J., Seaman, G.V. J. Cell. Physiol. (1978) [Pubmed]
  15. Identification of a role for the sialomucin CD164 in myogenic differentiation by signal sequence trapping in yeast. Lee, Y.N., Kang, J.S., Krauss, R.S. Mol. Cell. Biol. (2001) [Pubmed]
  16. The sialomucin CD164 (MGC-24v) is an adhesive glycoprotein expressed by human hematopoietic progenitors and bone marrow stromal cells that serves as a potent negative regulator of hematopoiesis. Zannettino, A.C., Bühring, H.J., Niutta, S., Watt, S.M., Benton, M.A., Simmons, P.J. Blood (1998) [Pubmed]
  17. Hematopoietic defects in mice lacking the sialomucin CD34. Cheng, J., Baumhueter, S., Cacalano, G., Carver-Moore, K., Thibodeaux, H., Thomas, R., Broxmeyer, H.E., Cooper, S., Hague, N., Moore, M., Lasky, L.A. Blood (1996) [Pubmed]
  18. CD164, a novel sialomucin on CD34(+) and erythroid subsets, is located on human chromosome 6q21. Watt, S.M., Bühring, H.J., Rappold, I., Chan, J.Y., Lee-Prudhoe, J., Jones, T., Zannettino, A.C., Simmons, P.J., Doyonnas, R., Sheer, D., Butler, L.H. Blood (1998) [Pubmed]
  19. Lymphocyte-HEV interactions in lymph nodes of a sulfotransferase-deficient mouse. van Zante, A., Gauguet, J.M., Bistrup, A., Tsay, D., von Andrian, U.H., Rosen, S.D. J. Exp. Med. (2003) [Pubmed]
  20. P-Selectin glycoprotein ligand 1 (PSGL-1) is a physiological ligand for E-selectin in mediating T helper 1 lymphocyte migration. Hirata, T., Merrill-Skoloff, G., Aab, M., Yang, J., Furie, B.C., Furie, B. J. Exp. Med. (2000) [Pubmed]
  21. Qualitative and quantitative changes in sialomucins during 1,2-dimethylhydrazine-induced colon carcinogenesis in the rat. McGarrity, T.J., Via, E.A., Colony, P.C. J. Natl. Cancer Inst. (1987) [Pubmed]
  22. A novel function for the nm23-H1 gene: overexpression in human breast carcinoma cells leads to the formation of basement membrane and growth arrest. Howlett, A.R., Petersen, O.W., Steeg, P.S., Bissell, M.J. J. Natl. Cancer Inst. (1994) [Pubmed]
  23. Distinct cell surface ligands mediate T lymphocyte attachment and rolling on P and E selectin under physiological flow. Alon, R., Rossiter, H., Wang, X., Springer, T.A., Kupper, T.S. J. Cell Biol. (1994) [Pubmed]
  24. Molecular cloning and functional analysis of SUT-1, a sulfate transporter from human high endothelial venules. Girard, J.P., Baekkevold, E.S., Feliu, J., Brandtzaeg, P., Amalric, F. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  25. Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells. Petersen, O.W., Rønnov-Jessen, L., Howlett, A.R., Bissell, M.J. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  26. Mechanism of neutrophil chemiluminescence induced by wheat germ agglutinin: partial characterization of the antigens recognized by wheat germ agglutinin. Ozaki, Y., Iwata, J., Ohashi, T. Blood (1984) [Pubmed]
  27. Platelet-derived microparticles bind to hematopoietic stem/progenitor cells and enhance their engraftment. Janowska-Wieczorek, A., Majka, M., Kijowski, J., Baj-Krzyworzeka, M., Reca, R., Turner, A.R., Ratajczak, J., Emerson, S.G., Kowalska, M.A., Ratajczak, M.Z. Blood (2001) [Pubmed]
  28. Enhanced sialylation of mucin-associated carbohydrate structures in human colon cancer metastasis. Bresalier, R.S., Ho, S.B., Schoeppner, H.L., Kim, Y.S., Sleisenger, M.H., Brodt, P., Byrd, J.C. Gastroenterology (1996) [Pubmed]
  29. Overexpression of sialomucin complex, a rat homologue of MUC4, inhibits tumor killing by lymphokine-activated killer cells. Komatsu, M., Yee, L., Carraway, K.L. Cancer Res. (1999) [Pubmed]
  30. Regulation of sialomucin production in colon carcinoma cells. Dohi, D.F., Sutton, R.C., Frazier, M.L., Nakamori, S., McIsaac, A.M., Irimura, T. J. Biol. Chem. (1993) [Pubmed]
  31. PEA3 transactivates the Muc4/sialomucin complex promoter in mammary epithelial and tumor cells. Perez, A., Barco, R., Fernandez, I., Price-Schiavi, S.A., Carraway, K.L. J. Biol. Chem. (2003) [Pubmed]
  32. Molecular cloning of a cDNA encoding CD34, a sialomucin of human hematopoietic stem cells. Simmons, D.L., Satterthwaite, A.B., Tenen, D.G., Seed, B. J. Immunol. (1992) [Pubmed]
  33. Colon epithelium. III. In vitro studies of colon carcinogenesis in Fischer 344 rats. N-methyl-N'-nitro-N-nitrosoguanidine-induced changes in colon epithelium in explant culture. Shamsuddin, A.K., Trump, B.F. J. Natl. Cancer Inst. (1981) [Pubmed]
  34. Biochemical characterization and molecular cloning of a novel endothelial-specific sialomucin. Morgan, S.M., Samulowitz, U., Darley, L., Simmons, D.L., Vestweber, D. Blood (1999) [Pubmed]
  35. Specific sensitivity of CD43 to neutrophil elastase. Remold-O'Donnell, E., Parent, D. Blood (1995) [Pubmed]
  36. Biosynthesis of the cell surface sialomucin complex of ascites 13762 rat mammary adenocarcinoma cells from a high molecular weight precursor. Sheng, Z.Q., Hull, S.R., Carraway, K.L. J. Biol. Chem. (1990) [Pubmed]
  37. trans-Sialidase from Trypanosoma cruzi binds host T-lymphocytes in a lectin manner. Todeschini, A.R., Girard, M.F., Wieruszeski, J.M., Nunes, M.P., DosReis, G.A., Mendonca-Previato, L., Previato, J.O. J. Biol. Chem. (2002) [Pubmed]
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