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Gene Review

Fbln5  -  fibulin 5

Rattus norvegicus

Synonyms: Dance, Developmental arteries and neural crest EGF-like protein, EVEC, Embryonic vascular EGF repeat-containing protein, FIBL-5, ...
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High impact information on Fbln5

  • EVEC mRNA expression is dramatically downregulated in adult arteries, except in the uterus, where cyclic angiogenesis continues; however, EVEC expression is reactivated in 2 independent rodent models of vascular injury [1].
  • With three available antibodies, our Western blotting analysis confirmed that there was an 85% increase in fibulin-5 (also known DANCE/EVEC) and a 71% decrease in cytochrome C oxidase (CCO) VIb subunit, but no change in succinate dehydrogenase complex (also known complex II) IP subunit in Cu-deficient rat heart [2].

Analytical, diagnostic and therapeutic context of Fbln5

  • Using in situ hybridization, we demonstrated that EVEC is expressed predominantly in the VSMCs of developing arteries in E11.5 through E16.5 mouse embryos [1].


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