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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Fbln5  -  fibulin 5

Rattus norvegicus

Synonyms: Dance, Developmental arteries and neural crest EGF-like protein, EVEC, Embryonic vascular EGF repeat-containing protein, FIBL-5, ...
 
 
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High impact information on Fbln5

  • EVEC mRNA expression is dramatically downregulated in adult arteries, except in the uterus, where cyclic angiogenesis continues; however, EVEC expression is reactivated in 2 independent rodent models of vascular injury [1].
  • With three available antibodies, our Western blotting analysis confirmed that there was an 85% increase in fibulin-5 (also known DANCE/EVEC) and a 71% decrease in cytochrome C oxidase (CCO) VIb subunit, but no change in succinate dehydrogenase complex (also known complex II) IP subunit in Cu-deficient rat heart [2].
 

Analytical, diagnostic and therapeutic context of Fbln5

  • Using in situ hybridization, we demonstrated that EVEC is expressed predominantly in the VSMCs of developing arteries in E11.5 through E16.5 mouse embryos [1].

References

  1. EVEC, a novel epidermal growth factor-like repeat-containing protein upregulated in embryonic and diseased adult vasculature. Kowal, R.C., Richardson, J.A., Miano, J.M., Olson, E.N. Circ. Res. (1999) [Pubmed]
  2. Copper deficiency increases fibulin-5 (DANCE/EVEC) but decreases cytochrome C oxidase VIb subunit expression in rat heart. Zeng, H., Saari, J.T., Dahlen, G.M. J. Inorg. Biochem. (2006) [Pubmed]
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