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Gene Review

FBLN5  -  fibulin 5

Homo sapiens

Synonyms: ADCL2, ARCL1A, ARMD3, DANCE, Dance, ...
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Disease relevance of FBLN5


Psychiatry related information on FBLN5


High impact information on FBLN5


Biological context of FBLN5


Anatomical context of FBLN5


Associations of FBLN5 with chemical compounds

  • The addition of morphine, methionine-enkephalin, or UP50, 488H which preferentially bind mu-, delta-, and kappa-opiate receptors, respectively, did not decrease basal irGnRH release from cultured human placental cells [13].
  • Fibulin-5 is an extracellular matrix glycoprotein that participates in elastogenesis [14].
  • Finally, the ability of FBLN-5 to antagonize angiogenic processes was determined to be independent of its integrin-binding RGD motif [15].

Physical interactions of FBLN5


Regulatory relationships of FBLN5


Other interactions of FBLN5


Analytical, diagnostic and therapeutic context of FBLN5


  1. Homozygosity for a missense mutation in fibulin-5 (FBLN5) results in a severe form of cutis laxa. Loeys, B., Van Maldergem, L., Mortier, G., Coucke, P., Gerniers, S., Naeyaert, J.M., De Paepe, A. Hum. Mol. Genet. (2002) [Pubmed]
  2. Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades. Schiemann, W.P., Blobe, G.C., Kalume, D.E., Pandey, A., Lodish, H.F. J. Biol. Chem. (2002) [Pubmed]
  3. Missense variations in the fibulin 5 gene and age-related macular degeneration. Stone, E.M., Braun, T.A., Russell, S.R., Kuehn, M.H., Lotery, A.J., Moore, P.A., Eastman, C.G., Casavant, T.L., Sheffield, V.C. N. Engl. J. Med. (2004) [Pubmed]
  4. Elastic fibres in health and disease. Kielty, C.M. Expert reviews in molecular medicine [electronic resource]. (2006) [Pubmed]
  5. Dance for health: improving fitness in African American and Hispanic adolescents. Flores, R. Public health reports (Washington, D.C. : 1974) (1995) [Pubmed]
  6. Wellness works: community service health promotion groups led by occupational therapy students. Scott, A.H. The American journal of occupational therapy. : official publication of the American Occupational Therapy Association. (1999) [Pubmed]
  7. Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo. Hirai, M., Ohbayashi, T., Horiguchi, M., Okawa, K., Hagiwara, A., Chien, K.R., Kita, T., Nakamura, T. J. Cell Biol. (2007) [Pubmed]
  8. Genetic heterogeneity of cutis laxa: a heterozygous tandem duplication within the fibulin-5 (FBLN5) gene. Markova, D., Zou, Y., Ringpfeil, F., Sasaki, T., Kostka, G., Timpl, R., Uitto, J., Chu, M.L. Am. J. Hum. Genet. (2003) [Pubmed]
  9. Fibulin-5 gene expression in human lung fibroblasts is regulated by TGF-beta and phosphatidylinositol 3-kinase activity. Kuang, P.P., Joyce-Brady, M., Zhang, X.H., Jean, J.C., Goldstein, R.H. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  10. Reduced secretion of fibulin 5 in age-related macular degeneration and cutis laxa. Lotery, A.J., Baas, D., Ridley, C., Jones, R.P., Klaver, C.C., Stone, E., Nakamura, T., Luff, A., Griffiths, H., Wang, T., Bergen, A.A., Trump, D. Hum. Mutat. (2006) [Pubmed]
  11. Inflammatory destruction of elastic fibers in acquired cutis laxa is associated with missense alleles in the elastin and fibulin-5 genes. Hu, Q., Reymond, J.L., Pinel, N., Zabot, M.T., Urban, Z. J. Invest. Dermatol. (2006) [Pubmed]
  12. Regulation of gene expression in endothelial cells: the role of human follicular fluid. Gruemmer, R., Klein-Hitpass, L., Neulen, J. J. Mol. Endocrinol. (2005) [Pubmed]
  13. Steroid hormones modulate the release of immunoreactive gonadotropin-releasing hormone from cultured human placental cells. Petraglia, F., Vaughan, J., Vale, W. J. Clin. Endocrinol. Metab. (1990) [Pubmed]
  14. Fibulin-5 distribution in human eyes: Relevance to age-related macular degeneration. Mullins, R.F., Olvera, M.A., Clark, A.F., Stone, E.M. Exp. Eye Res. (2007) [Pubmed]
  15. Fibulin-5 antagonizes vascular endothelial growth factor (VEGF) signaling and angiogenic sprouting by endothelial cells. Albig, A.R., Schiemann, W.P. DNA Cell Biol. (2004) [Pubmed]
  16. Fibulin-5 interacts with fibrillin-1 molecules and microfibrils. Freeman, L.J., Lomas, A., Hodson, N., Sherratt, M.J., Mellody, K.T., Weiss, A.S., Shuttleworth, A., Kielty, C.M. Biochem. J. (2005) [Pubmed]
  17. Effects of fibulin-5 on attachment, adhesion, and proliferation of primary human endothelial cells. Preis, M., Cohen, T., Sarnatzki, Y., Ben Yosef, Y., Schneiderman, J., Gluzman, Z., Koren, B., Lewis, B.S., Shaul, Y., Flugelman, M.Y. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  18. Induction of fibulin-5 gene is regulated by tropoelastin gene, and correlated with tropoelastin accumulation in vitro. Tsuruga, E., Yajima, T., Irie, K. Int. J. Biochem. Cell Biol. (2004) [Pubmed]
  19. Fibulin-5 mutations: mechanisms of impaired elastic fiber formation in recessive cutis laxa. Hu, Q., Loeys, B.L., Coucke, P.J., De Paepe, A., Mecham, R.P., Choi, J., Davis, E.C., Urban, Z. Hum. Mol. Genet. (2006) [Pubmed]
  20. Fibulin-5 deposition in human skin: decrease with ageing and ultraviolet B exposure and increase in solar elastosis. Kadoya, K., Sasaki, T., Kostka, G., Timpl, R., Matsuzaki, K., Kumagai, N., Sakai, L.Y., Nishiyama, T., Amano, S. Br. J. Dermatol. (2005) [Pubmed]
  21. Decreased expression of fibulin-5 correlates with reduced elastin in thoracic aortic dissection. Wang, X., LeMaire, S.A., Chen, L., Carter, S.A., Shen, Y.H., Gan, Y., Bartsch, H., Wilks, J.A., Utama, B., Ou, H., Thompson, R.W., Coselli, J.S., Wang, X.L. Surgery (2005) [Pubmed]
  22. Assignment of fibulin-5 (FBLN5) to human chromosome 14q31 by in situ hybridization and radiation hybrid mapping. Kowal, R.C., Jolsin, J.M., Olson, E.N., Schultz, R.A. Cytogenet. Cell Genet. (1999) [Pubmed]
  23. Premature osteoarthrosis in professional dancers. Teitz, C.C., Kilcoyne, R.F. Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine. (1998) [Pubmed]
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