Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

UL10 - type 3 membrane protein; 8 transmembrane...

Suid herpesvirus 1

Dijkstra, J.M. et al., Brack, A.R. et al.

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Disease relevance of UL10

Glycoprotein M (gM), the product of the UL10 gene of pseudorabies virus (PrV), is one of the few nonessential glycoproteins conserved throughout the Herpesviridae [1].
A rabbit antiserum directed against a synthetic oligopeptide representing the carboxy-terminal 18 amino acids of the predicted UL10 product recognized a major 45-kDa protein in lysates of purified Pr virions [2].
Sequence analysis within BamHI fragment 3 of the pseudorabies virus (PrV) genome revealed an open reading frame homologous to the UL10 gene of herpes simplex virus [2].

High impact information on UL10

In contrast to wild-type PrV strains, the UL10 gene product of the attenuated PrV vaccine strain Bartha (PrV-Ba) is not modified by N-glycans due to a mutation in the DNA sequence encoding the consensus N-glycosylation motif [1].

Analytical, diagnostic and therapeutic context of UL10

A PrV mutant lacking ca. 60% of UL10 coding sequences was able to productively replicate on noncomplementing cells, demonstrating that PrV gM is not required for viral replication in cell culture [2].

References

Inhibition of virion maturation by simultaneous deletion of glycoproteins E, I, and M of pseudorabies virus. Brack, A.R., Dijkstra, J.M., Granzow, H., Klupp, B.G., Mettenleiter, T.C. J. Virol. (1999) [Pubmed]
Identification and characterization of pseudorabies virus glycoprotein gM as a nonessential virion component. Dijkstra, J.M., Visser, N., Mettenleiter, T.C., Klupp, B.G. J. Virol. (1996) [Pubmed]

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