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Gene Review

UL50  -  deoxyuridine triphosphatase

Suid herpesvirus 1

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Disease relevance of UL50


High impact information on UL50

  • Our results thus demonstrate that UL50 of PrV encodes a protein of 33 kDa with dUTPase activity which copurifies with nuclei of infected cells and is dispensable for replication in cultured epithelial cells [2].
  • PrV UL50- replicated with an only slightly reduced efficiency in epithelial cells in culture compared with that of its parental wild-type virus strain [2].
  • The interruption of the UL50 gene led to the disappearance of the 33-kDa protein, whereas restoration of UL50 gene expression restored detection of the 33-kDa protein [2].
  • Another herpesvirus encoded enzyme that has received little attention as a potential target for the development of specific anti-herpesvirus agents is deoxyuridine triphosphate nucleotidohydrolase (dUTPase) [3].


  1. The UL49.5 gene of pseudorabies virus codes for an O-glycosylated structural protein of the viral envelope. Jöns, A., Granzow, H., Kuchling, R., Mettenleiter, T.C. J. Virol. (1996) [Pubmed]
  2. Identification and characterization of pseudorabies virus dUTPase. Jöns, A., Mettenleiter, T.C. J. Virol. (1996) [Pubmed]
  3. The herpesvirus encoded dUTPase as a potential chemotherapeutic target. Studebaker, A.W., Balendiran, G.K., Williams, M.V. Curr. Protein Pept. Sci. (2001) [Pubmed]
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